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2011 | 55 | 4 |

Tytuł artykułu

Vitamin C supplements influence zinc uptake and distribution in rats

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Wistar rats were fed for 28 d a diet comprising vitamin C administered in drinking water in a concentration of lg/L, concomitantly with traces of zinc 65 given intragastricallv. The body weight gains, organ to body ratios, blood values, and carcass and organ concentrations of zinc 65 were examined within 28 days postdosing. The supplement of vitamin C decreased significantly zinc 65 carcass retention, especially 4, 7, 14, and 28 d after administration. Comparable decreases in zinc 65 concentrations, calculated from the AUC values, were found in the liver, testicles, muscles, spleen, heart, and brain in rats maintained on the diet supplemented with vitamin C. On the contrary, the duodenum and kidneys of rats supplemented with vitamin C increased their zinc 65 concentrations. The vitamin C additive did not affect feed intake, body growth, organ to body ratios, and blood values.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

55

Numer

4

Opis fizyczny

p.807-809,fig.,ref.

Twórcy

autor
  • Department of Radiobiology, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

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  • 3. Evans C.W., Majors P.F., Cornatzer W.E.: Ascorbic acid interaction with metallothionein. Biochem Bioph Res Co 1970, 41, 1244-1247.
  • 4. Fox M.R.S., Fry B.: Cadmium toxicity decreased by dietary ascorbic acid supplements. Science 1970, 169, 291-297.
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  • 7. Guillot I., Lohr B., Weiser Fl., Halbach S., Rambeck W.A.: Influence of vitamin C on cadmium and mercury accumulation. J Anim Physiol Anim Nutr 1998, 80, 167-169.
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  • 9. Lynch S.R., Stoltzfus R.J.: Iron and ascorbic acid: proposed fortification levels and recommended iron compounds. J Nutr 2003 133, 2978S-2984S.
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  • 12. Olivares T.B., Cori H.: Enhancers of iron absorption: ascorbic acid and other organic acids. Int J Vitam Nutr Res 2004, 74, 403-419.
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  • 15. Rivers J.M.: Safety of high-level vitamin C ingestion. Int J Vitam Nutr Res Suppl 1989, 30, 95-102.
  • 16. Smith Ch. H., Bidlack W.E.: Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron, and copper in female guinea pigs. J Nutr 1980. 110, 1398-1408.
  • 17. Teucher B., Olivares M., Cori FI.: Enhancers of iron absorption: ascorbic acid and other organic acids. Int J Vitam Nutr Res 2004, 76, 403-419.
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  • 19. Van der Berg G.J., Yu S., Lemmens A.G., Beyen A.C.: Ascorbic acid feeding of rats reduces copper absorption, causing impaired copper status and depressed biliary copper excretion. Biol Trace Elem Res 1994, 41, 47-58.
  • 20. Watts D.C.: The nutritional relationship of zinc. J Orthomolec Med 1988, 3, 63-67.

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Bibliografia

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