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2018 | 27 | 3 |

Tytuł artykułu

Interactive effects of BDE-153 and its metabolite 2,4-DBP on biochemical status in crucian carp (Carassius auratus)


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Polybrominated diphenyl ethers (PBDEs), which belong to the class of brominated flame-retardants, are widely used in industrial products. PBDEs have been detected in varied environmental matrices and they can induce various toxicities such as neurotoxicity, cytotoxicity, and endocrine-disrupting effects in animals. The main objective of this study was to investigate the effects of 2,2’,4,4’,5,5’-hexabromodiphenyl ether (BDE-153), 2,4-dibromophenol (2,4-DBP), and their mixtures on the endocrine system, including acetylcholinesterase (AChE) of brain, ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), and superoxide dismutase (SOD) of liver in crucian carp (Carassius auratus). Fish were exposed to BDE-153 (0.2-100 mg/kg in food), 2,4-DBP (0.2-100 mg/kg in food), and their mixture for seven days. BDE-153 alone or in combination with 2,4-DBP significantly reduced brain AChE activity and increased liver EROD activity while no significant effects were observed for 2,4-DBP alone. The simultaneously elevated GST and SOD activities were found at higher doses of BDE-153 and 2,4-DBP (alone and in combination), and exhibited obvious positive correlation (0.76

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  • College of Hydraulic and Civil Engineering, XiZang Agricultural and Animal Husbandry College, Linzhi, China
  • Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China
  • Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China
  • Anhui Environmental Monitoring Center, Hefei 230061, China
  • Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China
  • Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China


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