Interactive effects of BDE-153 and its metabolite 2,4-DBP on biochemical status in crucian carp (Carassius auratus)

• Autorzy: Lu G. , Liu J. , Zhang F. , Nkoom M. , Wu D.
• Języki publikacji: EN

Abstrakty

EN

Polybrominated diphenyl ethers (PBDEs), which belong to the class of brominated flame-retardants, are widely used in industrial products. PBDEs have been detected in varied environmental matrices and they can induce various toxicities such as neurotoxicity, cytotoxicity, and endocrine-disrupting effects in animals. The main objective of this study was to investigate the effects of 2,2’,4,4’,5,5’-hexabromodiphenyl ether (BDE-153), 2,4-dibromophenol (2,4-DBP), and their mixtures on the endocrine system, including acetylcholinesterase (AChE) of brain, ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), and superoxide dismutase (SOD) of liver in crucian carp (Carassius auratus). Fish were exposed to BDE-153 (0.2-100 mg/kg in food), 2,4-DBP (0.2-100 mg/kg in food), and their mixture for seven days. BDE-153 alone or in combination with 2,4-DBP significantly reduced brain AChE activity and increased liver EROD activity while no significant effects were observed for 2,4-DBP alone. The simultaneously elevated GST and SOD activities were found at higher doses of BDE-153 and 2,4-DBP (alone and in combination), and exhibited obvious positive correlation (0.76

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2018
• Tom: 27
• Numer: 3
• Opis fizyczny: p.1155-1163,fig.,ref.

Twórcy

autor

Lu G.

• College of Hydraulic and Civil Engineering, XiZang Agricultural and Animal Husbandry College, Linzhi, China
• Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China

autor

Liu J.

• Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China

autor

Zhang F.

• Anhui Environmental Monitoring Center, Hefei 230061, China

autor

Nkoom M.

• Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China

autor

Wu D.

• Key Laboratory of Integrated Regulation and Resources Development, College of the Environment, Hohai University, Nanjing 210098, China

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Identyfikatory

DOI

10.15244/pjoes/76311