Comparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats

• Autorzy: Bilge H. , Basol O. , Yıldızhan E. , Ulger B.V. , Temiz H. , Akkus M. , Yıldızhan I.
• Języki publikacji: EN

Abstrakty

EN

Obesity, which is generally seen in adults, is a serious health problem. Diseases caused by obesity are among the leading causes of death worldwide. Liraglutide (LG) is an analogue of glucagon-like peptide-1, which slows gastrointestinal motility, resulting in decreased food consumption. Gastric plication (GP) and sleeve gastrectomy (SG) is the reduction of stomach volume by surgical means. We examined and compared the body mass index (BMI) changes, metabolic changes and changes in gastric histology in obese rats after LG injection with surgical methods such as SG and GP. In this research, 35 Wistar Albino female rats were used. Rats were divided into 5 groups with 7 rats in each group. Group (G) 1: The control group, fed with a normal calorie diet for 8 weeks. G 2: Sham group, G 3: SG group, G 4: GP group and G 5: LG group, fed with high-calorie feed for 4 weeks. At the end of the 4th week, the study was terminated by making appropriate interventions for the groups. When the blood glucose (BG) levels measured at the beginning, 4th week and 8th week of the experiment were evaluated, it was monitored that the BG level at the 8th week was the lowest in the LG group (p<0.05). It was observed that the preop Ghrelin and Leptin levels of the LG group were lower than those of the SG and GP groups (p<0.05). As a consequence of our metabolic investigations, we observed that the use of LG is at least as effective as SG.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2023
• Tom: 26
• Numer: 4
• Opis fizyczny: p.535-540,fig.,ref.

Twórcy

autor

Bilge H.

• Department of General Surgery, SBU Gazi Yaşargil Training and research Hospital, Elazığ Road 10.Km Üçkuyular location 21070, Diyarbakır, Turkey

autor

Basol O.

• Department of General Surgery, SBU Gazi Yaşargil Training and research Hospital, Elazığ Road 10.Km Üçkuyular location 21070, Diyarbakır, Turkey

autor

Yıldızhan E.

• Department of Histology and Embryology, Faculty of Medicine, Dicle University, Kıtılbıl Mah. 21280, Diyarbakır, Turkey

autor

Ulger B.V.

• Department of General Surgery, Faculty of Medicine, Dicle University, Kıtılbıl Mah. 21280, Diyarbakır, Turkey

autor

Temiz H.

• Department of Microbiology, Faculty of Medicine, Dicle University, Kıtılbıl Mah. 21280, Diyarbakır, Turkey

autor

Akkus M.

• Department of Histology and Embryology, Faculty of Medicine, Dicle University, Kıtılbıl Mah. 21280, Diyarbakır, Turkey

autor

Yıldızhan I.

• Department of Agricultural Technology, Faculty of Agricultural Technology, Iğdır University, Şehit Bülent Yurtseven Kampüsü, & Karaağaç Kampüsü, 76000 Iğdır, Turkey

Identyfikatory

DOI

10.24425/pjvs.2023.145059