Determination of sulfaguanidine in medicated feedingstuffs by liquid chromatography-mass spectrometry

• Autorzy: Przenioslo-Siwczynska M. , Kowalczyk E. , Kwiatek K.
• Języki publikacji: EN

Abstrakty

EN

A liquid chromatography-mass spectrometric method (LC-MS) for the determination of sulfaguanidine in medicated feedingstuffs was developed and validated. The samples were extracted using acidified methanol, centrifuged, and a portion of the extract was diluted with water. An appropriately diluted aliquot of the extract was analysed on a column 150 mm x 4.6 mm, 5 µm using a mixture of 0.1% formic acid in water and in acetonitrile as the mobile phase. The LC-MS was used in the positive atmospheric pressure chemical ionisation MS mode. The LC-MS method was validated for its linearity, precision, and specificity. Recovery from spiked samples was from 90.4% to 96.0% depending on sulfaguanidine concentration. The method was used for the quantitative determination of sulfaguanidine and its homogeneity in commercial medicated feedingstuffs.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2011
• Tom: 55
• Numer: 4
• Opis fizyczny: p.717-720,,fig.,ref.

Twórcy

autor

Przenioslo-Siwczynska M.

• Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Kowalczyk E.

autor

Kwiatek K.

Bibliografia

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