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2008 | 68 | 2 |
Tytuł artykułu

Cell death and neuronal arborization upon quercetin treatment in rat neurons

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as suplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to examine the effect of flavonoid on neurons morphology and their susceptibility to cell death. Fractal analysis of rat neurons revealed that 24 hours long incubation with quercetin diminished neuronal arborisation in cortical neurons. Neurons also appeared to be very sensitive to cell death after flavonoid treatment in concentration dependent manner. Over 50% of cells died after incubation with 15 μg/ml of flavonoid while 1 μg/ ml of quercetin induced cell death only in 5%. Staining with Hoechst 33342 and propidium ioidide revealed the two types of cell death: apoptosis and necrosis. The number of apoptotic cells was comparable with necrotic ones. These results suggest toxic effect of quercetin on neurons what should be taken into consideration in further studies on using quercetin as therapeutic agent.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
68
Numer
2
Opis fizyczny
p.139-146,fig.,ref.
Twórcy
  • Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Lublin, Poland
autor
  • Department of Virology and Immunology, Maria Curie-Sklodowska University, Lublin, Poland
  • Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
  • Department of Virology and Immunology, Maria Curie-Sklodowska University, Lublin, Poland
  • Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Lublin, Poland
autor
  • Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Lublin, Poland
Bibliografia
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-f65d9e23-fe19-43fe-96f7-917282b19b65
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