Fizjologiczna oporność na leptynę

• Autorzy: Gogga P. , Karbowska J. , Meissner W. , Kochan Z.

Warianty tytułu

EN

Physiological leptin resistance

• Języki publikacji: PL

Abstrakty

PL

Leptin is an adipose tissue-derived hormone whose circulating levels correlate with the amount of body fat stores. The main function of this adipokine is to regulate energy metabolism. By modulating the expression of orexigenic and anorexigenic neuropeptides in the hypothalamus, leptin reduces appetite. It also increases energy expenditure, contributing to the decrease of body fat and body weight. Mutations in the leptin receptor gene or prolonged consumption of a high-fat diet may impair leptin action, leading to leptin resistance. Resistance to leptin can also be an adaptive response that occurs in seasonal animals and in pregnant mammals. Reversible insensitivity to the satiety signal of leptin promotes hyperphagia, which is essential for animals living in dynamic environments and experiencing seasonal variation in food availability, since it allows them to forage intensely when food is abundant and accumulate fat reserves necessary to survive periods when food is scarce. Moreover, leptin resistance and subsequent hyperphagia develop during pregnancy in order to meet the energy needs of the growing fetus. Physiological leptin resistance may be due to impaired transport of leptin across the blood-brain barrier and/or to decreased sensitivity of the hypothalamus to this hormone resulting from an inhibition of leptin signalling in hypothalamic neurons. In pregnancy, an increased resistance to leptin action is also mediated by the binding of this adipokine to its placenta-derived soluble receptor. Reduced entry of leptin into the brain as well as alterations in the leptin signalling pathway in the hypothalamus leads to a transient decrease in sensitivity to this hormone preventing appetite suppression.

Słowa kluczowe

PL

ssaki; adipokiny; leptyna; opornosc na leptyne; regulacja apetytu; hiperfagia; fizjologia zwierzat

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2016
• Tom: 72
• Numer: 10
• Opis fizyczny: s.604-610,rys.,bibliogr.

Twórcy

autor

Gogga P.

• Zakład Higieny Żywności, Wydział Nauk o Zdrowiu, Gdański Uniwersytet Medyczny, ul.Dębinki 7, 80-211 Gdańsk

autor

Karbowska J.

• Katedra i Zakład Biochemii, Wydział Lekarski, Gdański Uniwersytet Medyczny, ul.Dębinki 1, 80-211 Gdańsk

autor

Meissner W.

• Pracownia Ekofizjologii Ptaków, Katedra Ekologii i Zoologii Kręgowców, Wydział Biologii, Uniwersytet Gdański, ul.Wita Stwosza 59, 80-308 Gdańsk

autor

Kochan Z.

• Zakład Higieny Żywności, Wydział Nauk o Zdrowiu, Gdański Uniwersytet Medyczny, ul.Dębinki 7, 80-211 Gdańsk

Bibliografia

• Augustine R. A., Grattan D. R.: Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology 2008, 149, 1049-1055.
• Bairlein F.: How to get fat: nutritional mechanisms of seasonal fat accumulation in migratory songbirds. Naturwissenschaften 2002, 89, 1-10.
• Banks A. S., Davis S. M., Bates S. H., Myers M. G. Jr.: Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 2000, 275, 14563-14572.
• Banks W. A., Clever C. M., Farrell C. L.: Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice. Am. J. Physiol. Endocrinol. Metab. 2000, 278, E1158-E1165.
• Ben-Jonathan N., Hugo E.: Prolactin (PRL) in adipose tissue: regulation and functions. Adv. Exp. Med. Biol. 2015, 846, 1-35.
• Bjørbaek C., Lavery H. J., Bates S. H., Olson R. K., Davis S. M., Flier J. S., Myers M. G. Jr.: SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 2000, 275, 40649-40657.
• Cerasale D. J., Zajac D. M., Guglielmo C. G.: Behavioral and physiological effects of photoperiod-induced migratory state and leptin on migratory bird, Zonotrichia albicollis: I. Anorectic effects of leptin administration. Gen. Comp. Endocrinol. 2011, 174, 276-286.
• Concannon P., Levac K., Rawson R., Tennant B., Bensadoun A.: Seasonal changes in serum leptin, food intake, and body weight in photoentrained woodchucks. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281, R951-R959.
• El-Haschimi K., Pierroz D. D., Hileman S. M., Bjørbaek C., Flier J. S.: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 2000, 105, 1827-1832.
• Florant G. L., Porst H., Peiffer A., Hudachek S. F., Pittman C., Summers S. A., Rajala M. W., Scherer P. E.: Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris). J. Comp. Physiol. B 2004, 174, 633-639.
• Friedman J. M., Mantzoros C. S.: 20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium. Metabolism 2015, 64, 1-4.
• Ganjam G. K., Benzler J., Pinkenburg O., Boucsein A., Stöhr S., Steger J., Culmsee C., Barrett P., Tups A.: Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes. J. Comp. Physiol. B 2013, 183, 1101-1111.
• García M. D., Casanueva F. F., Diéguez C., Señarís R. M.: Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biol. Reprod. 2000, 62, 698-703.
• Gavrilova O., Barr V., Marcus-Samuels B., Reitman M.: Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J. Biol. Chem. 1997, 272, 30546-30551.
• Gogga P., Karbowska J., Kochan Z., Meissner W.: Circulating leptin levels do not reflect the amount of body fat in the dunlin Calidris alpina during migration. Gen. Comp. Endocrinol. 2013, 187, 74-78.
• Gogga P., Karbowska J., Meissner W., Kochan Z.: Rola leptyny w regulacji metabolizmu lipidów i węglowodanów. Postepy Hig. Med. Dosw. 2011, 65, 255-262.
• Grattan D. R.: A mother’s brain knows. J. Neuroendocrinol. 2011, 23, 1188-1189.
• Grattan D. R.: 60 years of neuroendocrinology: The hypothalamo-prolactin axis. J. Endocrinol. 2015, 226, T101-T122.
• Grattan D. R., Ladyman S. R., Augustine R. A.: Hormonal induction of leptin resistance during pregnancy. Physiol. Behav. 2007, 91, 366-374.
• Gutman R., Choshniak I., Kronfeld-Schor N.: Defending body mass during food restriction in Acomys russatus: a desert rodent that does not store food. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290, R881-R891.
• Gutman R., Yosha D., Choshniak I., Kronfeld-Schor N.: Two strategies for coping with food shortage in desert golden spiny mice. Physiol. Behav. 2007, 90, 95-102.
• Hardie L., Trayhurn P., Abramovich D., Fowler P.: Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin. Endocrinol. 1997, 47, 101-106.
• Henson M. C., Castracane V. D.: Leptin in pregnancy. Biol. Reprod. 2000, 63, 1219-1228.
• Herrid M., Xia Y., O’Shea T., McFarlane J. R.: Leptin inhibits basal but not gonadotrophin-stimulated testosterone production in the immature mouse and sheep testis. Reprod. Fertil. Dev. 2008, 20, 519-528.
• Hileman S. M., Tornøe J., Flier J. S., Bjørbaek C.: Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology 2000, 141, 1955-1961.
• Johnstone L. E., Higuchi T.: Food intake and leptin during pregnancy and lactation. Prog. Brain Res. 2001, 133, 215-227.
• Kochan Z., Karbowska J., Meissner W.: Leptin is synthesized in the liver and adipose tissue of the dunlin (Calidris alpina). Gen. Comp. Endocrinol. 2006, 148, 336-339.
• Kronfeld-Schor N., Richardson C., Silvia B. A., Kunz T. H., Widmaier P.: Dissociation of leptin secretion and adiposity during prehibernatory fattening in little brown bats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 279, R1277-R1281.
• Król E., Duncan J. S., Redman P., Morgan P. J., Mercer J. G., Speakman J. R.: Photoperiod regulates leptin sensitivity in field voles, Microtus agrestis. J. Comp. Physiol. B 2006, 176, 153-163.
• Król E., Speakman J. R.: Regulation of body mass and adiposity in the field vole, Microtus agrestis: a model of leptin resistance. J. Endocrinol. 2007, 192, 271-278.
• Król E., Tups A., Archer Z. A., Ross A. W., Moar K. M., Bell L. M., Duncan J. S., Mayer C., Morgan P. J., Mercer J. G., Speakman J. R.: Altered expression of SOCS3 in the hypothalamic arcuate nucleus during seasonal body mass changes in the field vole, Microtus agrestis. J. Neuroendocrinol. 2007, 19, 83-94.
• Kurokawa T., Uji S., Suzuki T.: Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes. Peptides 2005, 26, 745-750.
• Ladyman S. R., Grattan D. R.: Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology 2004, 145, 3704-3711.
• Ladyman S. R., Grattan D. R.: Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology 2005, 146, 3868-3874.
• Lin L., Martin R., Schaffhauser A. O., York D. A.: Acute changes in the response to peripheral leptin with alteration in the diet composition. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 280, R504-R509.
• Margetic S., Gazzola C., Pegg G. G., Hill R. A.: Leptin: a review of its peripheral actions and interactions. Int. J. Obes. Relat. Metab. Disord. 2002, 26, 1407-1433.
• Mustonen A. M., Pyykönen T., Asikainen J., Hänninen S., Mononen J., Nieminen P.: Circannual leptin and ghrelin levels of the blue fox (Alopex lagopus) in reference to seasonal rhythms of body mass, adiposity, and food intake. J. Exp. Zool. A Comp. Exp. Biol. 2005, 303A, 26-36.
• Naef L., Woodside B.: Prolactin/Leptin interactions in the control of food intake in rats. Endocrinology 2007, 148, 5977-5983.
• Nagaishi V. S., Cardinali L. I., Zampieri T. T., Furigo I. C., Metzger M., Donato J. Jr.: Possible crosstalk between leptin and prolactin during pregnancy. Neuroscience 2014, 259, 71-83.
• Page-Wilson G., Reitman-Ivashkov E., Meece K., White A., Rosenbaum M., Smiley R. M., Wardlaw S. L.: Cerebrospinal fluid levels of leptin, proopiomelanocortin, and agouti-related protein in human pregnancy: evidence for leptin resistance. J. Clin. Endocrinol. Metab. 2013, 98, 264-271.
• Paolucci M., Rocco M., Varricchio E.: Leptin presence in plasma, liver and fat bodies in the lizard Podarcis sicula. Fluctuations throughout the reproductive cycle. Life Sci. 2001, 69, 2399-2408.
• Quillfeldt P., Everaert N., Buyse J., Masello J. F., Dridi S.: Relationship between plasma leptin-like protein levels, begging and provisioning in nestling thin-billed prions Pachyptila belcheri. Gen. Comp. Endocrinol. 2009, 161, 171-178.
• Rousseau K., Atcha Z., Loudon A. S. I.: Leptin and seasonal mammals. J. Neuroendocrinol. 2003, 15, 409-414.
• Schradin C., Raynaud J., Arrivé M., Blanc S.: Leptin levels in free ranging striped mice (Rhabdomys pumilio) increase when food decreases: The ecological leptin hypothesis. Gen. Comp. Endocrinol. 2014, 206, 139-145.
• Schultz M. A., Klomp N. I.: Does the foraging strategy of adult Short-tailed Shearwaters cause obesity in their chicks? J. Avian. Biol. 2000, 31, 287-294.
• Smith A. J., Clausen O. P. F., Kirkhus B., Jahnsen T., Møller O. M., Hansson V.: Seasonal changes in spermatogenesis in the blue fox (Alopex lagopus), quantified by DNA flow cytometry and measurement of soluble Mn2+-dependent adenylate cyclase activity. J. Reprod. Fertil. 1984, 72, 453-461.
• Spanovich S., Niewiarowski P. H., Londraville R. L.: Seasonal effects on circulating leptin in the lizard Sceloporus undulatus from two populations. Comp. Biochem. Physiol. B 2006, 143, 507-513.
• Sprent J., Jones S. M., Nicol S. C.: Does leptin signal adiposity in the egg-laying mammal, Tachyglossus aculeatus? Gen. Comp. Endocrinol. 2012, 178, 372-379.
• Tena-Sempere M., Pinilla L., González L. C., Diéguez C., Casanueva F. F., Aguilar E.: Leptin inhibits testosterone secretion from adult rat testis in vitro. J. Endocrinol. 1999, 161, 211-218.
• Trujillo M. L., Spuch C., Carro E., Señarís R.: Hyperphagia and central mechanisms for leptin resistance during pregnancy. Endocrinology 2011, 152, 1355-1365.
• Tups A., Ellis C., Moar K. M., Logie T. J., Adam C. L., Mercer J. G., Klingenspor M.: Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (Suppressor of Cytokine Signaling) gene expression. Endocrinology 2004, 145, 1185-1193.
• Tups A., Stöhr S., Helwig M., Barrett P., Krol E., Schachtner J., Mercer J. G., Klingenspor M.: Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. J. Comp. Physiol. B 2012, 182, 553-567.
• Zampieri T. T., Ramos-Lobo A. M., Furigo I. C., Pedroso J. A., Buonfiglio D. C., Donato J. Jr.: SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes. Mol. Metab. 2014, 4, 237-245.
• Zhang Y., Guo K. Y., Diaz P. A., Heo M., Leibel R. L.: Determinants of leptin gene expression in fat depots of lean mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 282, R226-R234.
• Zhou Y., Rui L.: Leptin signaling and leptin resistance. Front. Med. 2013, 7, 207-222.
• Zhu W. L., Zhang L., Wang Z. K.: Effects of exogenous leptin on body mass, thermogenesis capacity and hormone concentrations of yuman chinese vole, Eothenomys miletus, under varied photoperiod. Pakistan J. Zool. 2013, 45, 997-1006.

Identyfikatory

DOI

10.21521/mw.5576