Old rhythm, new methodology: differential temporal organization of sleep-wake states in the light and dark phase

• Autorzy: Smyk M.K. , Luijtelaar,van G. , Drinkenburg W.
• Języki publikacji: EN

Abstrakty

EN

Sleep-wake cycle, a dynamic process of alternating states of vigilance, is usually described by means of quantitative methods. In our EEG study performed on WAG/Rij rats, a validated, genetic animal model of absence epilepsy, correlation and cross-correlation functions over time were applied on 24 h data collected in 12:12 light-dark cycle in order to investigate temporal coupling between absence seizures and sleep-wake states, and between sleep-wake states themselves. We found significant light/ dark-related differences in temporal organization: first, absence seizures showed bidirectional coupling with sleep-wake states in the dark phase only. Second, temporal relationships among states of vigilance followed phase-related alterations, which were the most prominent at the light onset. These results were confirmed in a non-epileptic control strain. Our approach suggests that different processes are governing sleep and wake in the light and dark period.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.50

Twórcy

autor

Smyk M.K.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland
• Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

Luijtelaar,van G.

• Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands

autor

Drinkenburg W.

• Janssen Research and Development, Department of Neurosciences, Johnson and Johnson Pharmaceutical Companies, Beerse, Belgium