Różnorodność wirusa RHD - znaczenie epidemiologiczne, diagnostyczne i immunologiczne

• Autorzy: Fitzner A. , Niedbalski W.

Warianty tytułu

EN

The diversity of RHD virus: epidemiological, diagnostic and immunological importance

• Języki publikacji: PL

Abstrakty

EN

Rabbit haemorrhagic disease (RHD) was first recognized in China in 1984. In Europe, the disease appeared in 1986 in Italy, and in the following years RHD was observed in many other European countries, including Poland in 1988. The disease is caused by RHD virus (RHDV), classified as a representative of the Lagovirus genus within the Caliciviridae family. Lagoviruses include the non-pathogenic rabbit calicivirus (RCV) and the European brown hare syndrome virus (EBHSV). There are three basic variants (subtypes) of pathogenic RHD viruses: classic (RHDV) and antigenic subtypes RHDVa and RHDV2 (RHDVb), distinguished on the basis of epidemiological characteristics, infectious properties and antigenic and genetic modifications. Phylogenetic analysis of RHDV revealed the presence of five genogroups (G1-G5) with similar time of isolation, regardless of the place of occurrence. RHDVa strains are genetically more variable than RHDV, and all RHDVa strains belong to genogroup G6. RHDV2 was diagnosed for the first time in 2010 in domestic and wild rabbits in France, and later in the Iberian Peninsula, and it was called RHDVb. Like the previously identified variants of the RHD virus, RHDV2 spreads to other regions of the world, and in 2011-2016 it was diagnosed in many European countries, North America, Africa and Australia. Strains of RHD2 form a separate, uniform phylogenetic group and are more similar to the non-pathogenic rabbit calicivirus than to pathogenic RHDV and RHDVa. Infections with different variants of RHD viruses are a serious epidemiological, diagnostic and immunological problem. Advanced antigenic changes in RHD viruses limit the usefulness of standard RHD vaccines in controlling the disease.

Słowa kluczowe

PL

wirusologia; czynniki chorobotworcze; wirus krwotocznej choroby krolikow; wirus RHD; roznorodnosc; zmiennosc; podtypy

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2017
• Tom: 73
• Numer: 12
• Opis fizyczny: s.811-818,rys.,bibliogr.

Twórcy

autor

Fitzner A.

• Zakład Pryszczycy, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, ul.Wodna 7, 98-220 Zduńska Wola

autor

Niedbalski W.

• Zakład Pryszczycy, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, ul.Wodna 7, 98-220 Zduńska Wola

Bibliografia

• Abrantes J., Esteves P. J., van der Loo W.: Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV). Arch. Virol. 2008, 153, 329-335.
• Abrantes J., Lopes A. M., Dalton K. P., Parra F., Esteves P. J.: Detection of RHDVa on the Iberian Peninsula: isolation of an RHDVa strain from a Spanish rabbitry. Arch. Virol 2014, 159, 321-326.
• Alda F., Gaitero T., Suarez M., Merchan T., Rocha G., Doadrio I.: Evolutionary history and molecular epidemiology of rabbit haemorrhagic disease virus in the Iberian Peninsula and Western Europe. BMC Evol. Biol. 2010, 10:347. DOI: 10.1186/1471-2148-10-347.
• Almeida T., Lopes A. M., Magalhães M. J., Neves F., Pinheiro A., Goncalves D., Leitão M., Esteves P. J., Abrantes J.: Tracking the evolution of the G1/RHDVb recombinant strains introduced from the Iberian Peninsula to the Azores islands, Portugal. Infect. Gen. Evol. 2015, 34, 307-313.
• Asgari S., Hardy J. R. E., Cooke B. D.: Sequence analysis of rabbit haemorrhagic disease virus (RHDV) in Australia: alterations after its release. Arch. Virol. 1999, 144, 135-145.
• Baily J. L., Dagleish M. P., Graham M., Maley M., Rocchi M. S.: RHDV variant 2 presence detected in Scotland. Vet. Rec. 2014, 174, 411.
• Bárcena J., Guerra B., Angulo I., González J., Valcárcel F., Mata C. P., Castón J. R., Blanco E., Alejo A.: Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles. Vet. Res. 2015, 46, 106.
• Bergin I. L., Wise A. G., Bolin S. R., Mullaney T. P., Kiupel M., Maes R. K.: Novel calicivirus identified in rabbits, Michigan, USA. Emerg. Inf. Dis. 2009, 15, 1955-1962.
• Boucher S., Rubeaux D., Le Gall-Reculé G., Rigaudeau A.: Cartographie des cas de VHD à RHDV2 (virus variant 2010) à partir des virus isolés depuis 2010 de lapins domestiques en France métropolitaine, sur l’ile de la Reunion et en Espagne à l’aide d’une technique de RT-PCR temps reel. 2015, 16èmes Jour. Rech. Cunicole, 24-25 novembre, Le Mans, France, s. 25-28.
• Bruce J. S., Twigg L. E.: Rabbit Haemorrhagic Disease: serological evidence of a non-virulent RHDV-like virus in south-western Australia. Wildl. Res. 2004, 31, 605-612.
• Burmakina G., Malogolovkina N., Lunitsin A., Titov I., Tsybanov S., Malogolovkin A.: Comparative analysis of rabbit hemorrhagic disease virus strains originating from outbreaks in the Russian Federation. Arch. Virol. 2016, 161, 1973-1979.
• Camarda A., Pugliese N., Cavadini P., Circella E., Capucci L., Caroli A., Legretto M., Mallia E., Lavazza A.: Detection of the new emerging rabbit haemorrhagic disease type 2 virus (RHDV2) in Sicily from rabbit (Oryctolagus cuniculus) and Italian hare (Lepus corsicanus). Res. Vet. Sci. 2014, 97, 642-645.
• Cancellotti F. M., Renzi M.: Epidemiology and the current situation of viral haemorrhagic disease of rabbits and the European brown hare syndrome in Italy. Rev. Sci. Tech. 1991, 10, 409-422.
• Capucci L., Fallacara F., Grazioli S., Lavazza A., Pacciarini M. L., Brocchi E.: A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant. Virus Res. 1998, 58, 115-126.
• Capucci L., Fusi P., Lavazza A., Pacciarini M. L., Rossi C.: Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic. J. Virol. 1996, 70, 8614-8623.
• Capucci L., Scicluna M. T., Lavazza A.: Diagnosis of viral haemorrhagic disease of rabbits and the European brown hare syndrome. Rev. Sci. Tech. 1991, 10, 347-370.
• Chasey D.: Rabbit haemorrhagic disease: the new scourge of Oryctolagus cuniculus. Lab. Anim. 1997, 31, 33-44.
• Chrobocińska M., Mizak B.: Phylogenetic analysis of partial capsid protein gene of rabbit haemorrhagic disease virus (RHDV) strains isolated between 1993 and 2005 in Poland. B. Vet. I. Pulawy 2007, 51, 189-197.
• Cooke B. D.: Rabbit haemorrhagic disease: field epidemiology and the management of wild rabbit populations. Rev. Sci. Tech. 2002, 21, 347-358.
• Dalton K. P., Nicieza I., Abrantes J., Esteves P. J.: Spread of new variant RHDV in domestic rabbits on the Iberian Peninsula. Vet. Microbiol. 2014, 169, 67-73.
• Dalton K. P., Nicieza I., Balseiro A., Muguerza M. A., Rosell J. M., Casais R., Alvarez A. L., Parra F.: Variant rabbit hemorrhagic disease virus in young rabbits, Spain. Emerg. Inf. Dis. 2012, 18, 2009-2012.
• Duarte M. D., Henriques A. M., Barros S., Luis T., Fagulha T., Ramos F., Fevereiro M.: New insight into the epidemiology of rabbit hemorrhagic diseases viruses in Portugal: Retrospective study reveals the circulation of genogroupe 5 (G5) in Azores and discloses the circulation of G1 and G6 strains in mainland until 2008. Infect. Gen. Evol. 2014, 27, 149-155.
• Esteves P. J., Abrantes J., Bertagnoli S., Cavadini P., Gavier-Widén D., Guitton J.-S.: Emergence of pathogenicity in lagoviruses: Evolution from pre-existing nonpathogenic strains or through a species jump? PLOS pathog. 2015, 11 (11): e1005087. DOI: 10.1371/journal.ppat.1005087.
• Esteves P. J., Abrantes J., Carneiro M., Müller A., Thompson G., van der Loo W.: Detection of positive selection in the major capsid protein VP60 of the rabbit haemorrhagic disease virus (RHDV). Virus Res. 2008, 137, 253-256.
• Fitzner A.: Characterisation and immunogenic properties of Polish strains of RHD virus. B. Vet. I. Pulawy 2009, 53, 575-582.
• Fitzner A., Kęsy A.: Variability of Polish isolates of the RHD virus. Med. Weter. 2003, 59, 905-908.
• Fitzner A., Niedbalski W.: Serological survey for RHD antibodies in rabbits from two types of rabbit breeding farms. Pol. J. Vet. Sci. 2016, 19, 597-607.
• Forrester N. L., Moss S. R., Turner S. L., Schirrmeier H., Gould E. A.: Recombination in rabbit haemorrhagic disease virus: Possible impact on evolution and epidemiology. Virology 2008, 376, 390-396.
• Forrester N. L., Trout R. C., Gould E. A.: Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology 2007, 358, 18-22.
• Gavier-Widen D., Mörner T.: Epidemiology and diagnosis of the European brown hare syndrome in Scandinavian countries: a review. Rev. Sci Tech. 1991, 10, 453-458.
• Górski J., Mizak B., Mizak Z., Komorowski A.: Obraz kliniczny oraz zmiany anatomopatologiczne w przebiegu pomoru królików (wirusowej krwiotocznej bronchopneumonii królików). Życie Wet. 1988, 63, 266-269.
• Gregg D. A., House C., Meyer R., Berninger M.: Viral haemorrhagic disease of rabbits in Mexico: epidemiology, and viral characterization. Rev. Sci. Tech. 1991, 10, 435-451.
• Hall R. N., Mahar J. E., Haboury S., Stevens V., Holmes E. C., Strive T.: Emerging rabbit hemorrhagic disease virus 2 (RHDVb), Australia. Emerging Infect. Dis. 2015, 21, 2276-2278.
• Hall R. N., Peacock D. E., Kovaliski J., Mahar J. E., Mourant R., Piper M., Strive T.: Detection of RHDV2 in European brown hares (Lepus europaeus) in Australia. Vet. Rec. 2016. DOI: 10.1136/vr.104034.
• Jahnke M., Holmes E. C., Kerr P. J., Wright J. D., Strive T.: Evolution and phylogeography of the nonpathogenic calicivirus RCV-A1 in wild rabbits in Australia. J. Virol. 2010, 84, 12397-12404.
• Kerr P. J., Kitchen A., Holmes E. C.: The origin and phylodynamics of rabbit hemorrhagic disease virus. J. Virol. 2009, 83, 12129-12138.
• Kęsy A., Fitzner A., Niedbalski W., Paprocka G., Walkowiak B.: A new variant of the viral haemorrhagic disease of rabbits virus. Rev. Sci. Tech. 1996, 15, 1029-1035.
• Lavazza A., Cavadini P., Barbieri I., Tizzani P., Pinheiro A., Abrantes J., Esteves P. J., Grilli G., Gioia E., Zanoni M., Meneguz P. G., Guitton J. S., Marchandeau S., Chiari M., Capucci L.: Field and experimental data indicate that the eastern cottontail (Sylvilagus floridanus) is susceptible to infection with European brown hare syndrome (EBHS) virus and not with rabbit haemorrhagic disease (RHD) virus. Vet. Res. 2015. DOI 10.1186/s13567-015-0149-4.
• Lavazza A., Scicluna M. T., Capucci L.: Susceptibility of hares and rabbits to the European brown hare syndrome virus (EBHSV) and rabbit haemorrhagic disease virus (RHDV) under experimental conditions. J. Vet. Med. B 1996, 43, 401-410.
• Lee C. S., Park C. K.: Aetiological studies on a acute fatal disease of Angora rabbits: so-called rabbit viral sudden death. Korean J. Vet. Res. 1987, 27, 277-290.
• Le Gall G., Arnauld C., Boilletot E., Morisse J. P., Rasschaert D.: Molecular epidemiology of rabbit haemorrhagic disease virus outbreaks in France during 1988 to 1995. J. Gen. Virol. 1998, 79, 11-16.
• Le Gall-Reculé G., Lavazza A., Marchandeau S., Bertagnoli S., Zwingelstein F., Cavadini P., Martinelli N., Lombardi G., Guerin J. L., Lemaitre E., Decors A., Boucher S., Le Normand B., Capucci L.: Emergence of a new lagovirus related to rabbit haemorrhagic disease virus. Vet. Res. 2013, 44:81. DOI: 10.1186/1297-9716-44-81.
• Le Gall-Reculé G., Zwingelstein F., Fages M. P., Bertagnoli S., Gelfi J., Aubineau J., Roobrouck A., Botti G., Lavazza A., Marchandeau S.: Characterisation of a non-pathogenic and non-protective infectious rabbit lagovirus related to RHDV. Virology 2011, 410, 395-402.
• Le Gall-Reculé G., Zwingelstein F., Laurent S., de Boissésson C., Portejoie Y., Rasschaert D.: Phylogenetic analysis, of rabbit haemorrhagic disease virus in France between 1993 and 2000, and the characterisation of RHDV antigenic variants. Arch. Virol. 2003, 148, 65-81.
• Le Minor O., Beilvert F., Le Moullec T., Djadour D., Martineau J.: Evaluation de l’efficacité d’un nouveau vaccin contre le virus variant de la maladie hémorragique du lapin (VHD). 15èmes Jour. Rech. Cunicole. 2013, 19-20 Novembre, Le Mans, France, s. 241-244.
• Liu S. J., Xue H. P., PU B. Q., Qian N. H.: A new viral disease in rabbits. Anim. Husb. Vet. Med. 1984, 16, 253-255.
• Löliger H. C., Eskens U.: Incidence, epizootiology and control of viral haemorrhagic disease of rabbits and the European brown hare syndrome in Germany. Rev. Sci. Tech. 1991, 10, 423-434.
• Lopes A. M., Correia J., Abrantes J., Melo P., Ramada M., Magalhães M. J., Alves P. C., Esteves P. J.: Is the new variant RHDV replacing genogroup 1 in Portuguese wild rabbit populations? Viruses 2015, 7, 27-36.
• Lopes A. M., Dalton K. P., Magalhães M. J., Parra F., Esteves P. J., Holmes E. C., Abrantes J.: Full genomic analysis of new variant rabbit hemorrhagic disease virus (RHDVb) revealed multiple recombination events. J. Gen. Virol. 2015, 96, 1309-1319.
• Lopes A. M., Marques S., Silva E., Magalhães M. J., Pinheiro A., Alves P. C., Le Pendu J., Esteves P. J., Thompson G., Abrantes J.: Detection of RHDV strains in the Iberian hare (Lepus granatensis): earliest evidence of rabbit lagovirus cross-species infection. Vet. Res. 2014, 45:94. DOI: 10.1186/s13567-014-0094-7.
• Marcato P. S., Benazzi C., Vecchi G., Galeotii M., Della Salda I., Sarli G., Lucidi P.: Clinical and pathological features of viral haemorrhagic disease of rabbits and the European brown hare syndrome. Rev. Sci. Tech. 1991, 10, 371-392.
• Marchandeau S., Le Gall-Reculé G., Bertagnoli S., Aubineau J., Botti G., Lavazza A.: Serological evidence for a non-protective RHDV-like virus. Vet. Res. 2005, 36, 53-62.
• Matiz K., Ursu K., Kecskemeti S., Bajmocy E., Kiss I.: Phylogenetic analysis of rabbit haemorrhagic disease virus (RHDV) strains isolated between 1988 and 2003 in eastern Hungary. Arch. Virol. 2006, 151, 1659-1666.
• McIntosh M. T., Behan S. C., Mohamed F. M., Lu Z., Moran K. E., Burrage T. G., Neilan J. G., Ward G. B., Botti G., Capucci L., Metwally S. A.: A pandemic strain of calicivirus threatens rabbit industries in the Americas. Virology J. 2007, 4:96. DOI 10.1186/1743-422X-4-96.
• Meyers G., Wirblich Ch., Thiel H. J.: Rabbit hemorrhagic disease virus – molecular cloning and nucleotide sequencing of a calivirus genome. Virology 1991, 184, 664-676.
• Morisse J. P., Le Gall G., Boilletot E.: Hepatitis of viral origin in Leporidae: introduction and aetiological hypotheses. Rev. Sci. Tech. 1991, 10, 283-295.
• Moss S. R., Turner S. L., Trout R. C., White P. J., Hudson P. J., Desai A., Armesto M., Forrester N. L., Gould E. A.: Molecular epidemiology of Rabbit haemorrhagic disease virus. J. Gen. Virol. 2002, 83, 2461-2467.
• Novotny M., Ros-Bascunana C., Ballagi-Pordany A., Gavier-Widen D., Uhlen M., Belak S.: Phylogenetic analysis of rabbit haemorrhagic disease and European brown hare syndrome viruses by comparison of sequences from the capsid protein gene. Arch. Virol. 1997, 142, 657-673.
• Ohlinger V. F., Haas B., Meyers G., Weiland F., Thiel H. J.: Identification and characterization of the virus causing rabbit hemorrhagic disease. J. Virol. 1990, 64, 3331-3336.
• Puggioni G., Cavadini P., Maestrale C., Scivoli R., Botti G., Ligios C., Le Gall-Reculé G., Lavazza A., Capucci L.: The new French 2010 Rabbit hemorrhagic disease virus causes an RHD-like disease in the Sardinian Cape hare (Lepus capensis mediterraneus). Vet. Res. 2013, 44:96. DOI: 10.1186/1297-9716-44-96.
• Rodák L., Šmid B., Valiček L., Veselý T., Štěpánek J., Hampl J., Jurák E.: Enzyme-linked immunosorbent assay of antibodies to rabbit haemorrhagic disease virus and determination of its major structural proteins. J. Gen. Virol. 1990, 71, 1075-1080.
• Schirrmaier H., Reimann I., Köllner B., Granzow H.: Pathogenic, antigenic and molecular properties of rabbit haemorrhagic disease virus (RHDV) isolated from vaccinated rabbits: detection and characterization of antigenic variants. Arch. Virol. 1999, 144, 719-735.
• Strive T., Wright J. D., Robinson A. J.: Identification and partial characterisation of a new lagovirus in Australian wild rabbits. Virology 2009, 384, 97-105.
• Velarde R., Cavadini P., Neimanis A., Cabezon O., Chiari M., Gaffuri A., Lavin S., Grilli G., Gavier-Widen D., Lavazza A., Capucci L.: Spillover events of infection of Brown hares (Lepus europaeus) with rabbit heamorrhagic disease type 2 virus (RHDV2) caused sporadic cases of an European Brown Hare Syndrome-like disease in Italy and Spain. Transbound. Emerg. Dis. 2016. DOI 10.1111/tbed.12562.
• Westcott D. G., Frossard J. P., Everest D., Dastjerdi A., Duff J. P., Steinbach F., Choudhury B.: Incursion of RHDV2-like variant in Great Britain. Vet. Rec. 2014, 174, 333.

Identyfikatory

DOI

10.21521/mw.5815