Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis

• Autorzy: Laus M.N. , Denoth F. , Ciardi M. , Giorgetti L. , Pucci L. , Sacco R. , Pastore D. , Longo V.
• Języki publikacji: EN

Abstrakty

EN

Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2013
• Tom: 69
• Numer: 04
• Opis fizyczny: p.235-240,fig.,ref.

Twórcy

autor

Laus M.N.

• Dipartimento di Scienze Agrarie, degli Alimenti e dell'Ambiente, Universita degli Studi di Foggia, Via Napoli 25, 71122 Foggia, Italy

autor

Denoth F.

• Istituto di Fisiologia Clinica, CNR, Via Moruzzi 2, 56100 Pisa, Italy

autor

Ciardi M.

• Istituto di Biologia e Biotecnologia Agraria, CNR, Via Moruzzi 2, 56100 Pisa, Italy

autor

Giorgetti L.

• Istituto di Biologia e Biotecnologia Agraria, CNR, Via Moruzzi 2, 56100 Pisa, Italy

autor

Pucci L.

• Istituto di Biologia e Biotecnologia Agraria, CNR, Via Moruzzi 2, 56100 Pisa, Italy

autor

Sacco R.

• Unita Operativa Gastroenterologia e Malattie del Ricambio, AOUP, 56124 Pisa, Italy

autor

Pastore D.

• Dipartimento di Scienze Agrarie, degli Alimenti e dell'Ambiente, Universita degli Studi di Foggia, Via Napoli 25, 71122 Foggia, Italy

autor

Longo V.

• Istituto di Biologia e Biotecnologia Agraria, CNR, Via Moruzzi 2, 56100 Pisa, Italy

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