Plasma Ab levels as predictors of response to rivastigmine treatment in Alzheimer's disease

• Autorzy: Sobow T. , Flirski M. , Liberski P. P. , Kloszewska I.
• Języki publikacji: EN

Abstrakty

EN

Cholinesterase inhibitors are currently the mainstream of symptomatic treatment of patients with Alzheimer's disease. The response to treatment with cholinesterase inhibitors is clinically difficult to predict. Several demographic, clinical and biological variables have been proposed as pretreatment predictors of long-term therapy efficacy. In this paper, consistently with previous reports, we confirm that higher initial disease severity and faster progression of cognitive impairment increase the chance of a clinically meaningful response to cholinesterase inhibitor therapy in a carefully selected population of patients with Alzheimer's disease. Moreover, for the first time we demonstrate the association between the increase in the concentration of plasma Ab1-42 peptide after 2 weeks of treatment with an initial dose of rivastigmine and the likelihood of a positive response to treatment after 6 months. A change in plasma Ab1-42 level might constitute a novel biochemical predictor of rivastigmine treatment efficacy in Alzheimer's diseases.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2007
• Tom: 67
• Numer: 2
• Opis fizyczny: p.131-139,ref.

Twórcy

autor

Sobow T.

• Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland

autor

Flirski M.

• Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland

autor

Liberski P. P.

• Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland

autor

Kloszewska I.

• Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland

Uwagi

PL

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