Hyperoside isolated from Impatiens glandulifera Royle alleviates depressive and anxiety-like responses in a mouse model of posttraumatic stress disorder

• Autorzy: Orzelska-Gorka J. , Szewczyk K. , Kedzierska E. , Glowacka E. , Kruk-Slomka M. , Biala G.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: Posttraumatic stress disorder (PTSD) is a chronic and prevalent psychiatric condition that may develop following exposure to traumatic events. Depressive symptoms and anxiety belong to the most frequent symptoms observed in PTSD patients. Less than 30% of PTSD patients achieve full remission with the use of available drugs. For this purpose, there is a clear need to develop more efficient and safer drugs as alternative and/or complimentary therapy for PTSD. Hyperoside (HYP) is one of the polyphenols found in Impatiens glandulifera. Our previous experiments showed that HYP exerted antidepressant effects, both after acute and chronic (14 days) treatment in mice in the forced swimming test (FST; data not published). AIM(S): The present study aimed to investigate the effect of HYP on the behavioural impairments (depression and anxiety) induced by a mouse single prolonged stress (mSPS) – a rodent model of PTSD. METHOD(S): mSPS protocol: mice were exposed to a series of short stressors. In particular, they were restrained for 2 h in a Plexiglas tubes (50 ml), placed in glass beakers and immersed in water (23‑25°C) for a group swim (10 min). Then, they were exposed to a beaker of soiled bedding taken from cages of rats (15 min), and at the end, they were exposed to anhydrous diethyl ether until they lost consciousness (approx. 2 – 3 min). Seven days after exposure to SPS, the administration of substances was started (during next 14 days). Then, animals were subjected to behavioural tests, including the elevated plus-maze test (EPM), measurement of locomotion, and FST. RESULTS: Mice given chronically HYP (3.75 and 7.5 mg/kg) after exposure to mSPS exhibited a reduction of immobility time in FST, and more open arm entries and longer open arms duration in EPM without affecting locomotor activity as compared to control‑mSPS group. CONCLUSIONS: In summary, our results suggested the potential of HYP in alleviating the mSPS-induced depressive and anxiety‑like responses.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: Suppl.1
• Opis fizyczny: p.LXXIII-LXXIV

Twórcy

autor

Orzelska-Gorka J.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Szewczyk K.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Kedzierska E.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Glowacka E.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Kruk-Slomka M.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Biala G.

• Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland