Occupational pesticide exposure and cognitive impairment among adult farmers in northern Thailand

• Autorzy: Phitsadang N. , Naksen W. , Ong-Artborirak P.
• Języki publikacji: EN

Abstrakty

EN

Background. Thai farmers are directly exposed to pesticides, which may result in adverse effects including cognitive impairment. Objectives. The aim of this study was to examine the association between occupational pesticide exposure and cognitive decline among adult farmers in northern Thailand. Material and Methods. This cross-sectional study included 303 pesticide-using farmers over the age of 50 from Doi Tao District in Chiang Mai Province. Pesticide exposure score was calculated using an algorithm that considered personal protective equipment (PPE) scores and exposure intensity scores, as well as lifetime application days. The scores were classified as high or low exposure based on their median. The Thai version of the Montreal Cognitive Assessment (MoCA) test was used to assess cognitive function. Results. The mean age of adult farmers was 58.74 years. The prevalence of cognitive impairment was 93.7%, with an average score of 19.6. Spearman’s rank correlation coefficient showed that the MoCA score was adversely correlated with lifetime application days (rs = -0.145), PPE score (rs = -0.163), exposure intensity score (rs = -0.184), and pesticide exposure score (rs = -0.225). Linear regression revealed that high exposed farmers had significantly lower MoCA scores than low exposed farmers, as measured by PPE score (B = -0.75; 95% CI: -1.46, -0.05), exposure intensity score (B = -0.97; 95% CI: -1.66, -0.27), and pesticide exposure score (B = -0.77; 95% CI: -1.47, -0.06), after controlling for sex, age, education, income sufficiency, and body mass index. Conclusions. Thai farmers are at risk of cognitive impairment linked to occupational pesticide exposure, depending on their PPE use and exposure intensity. There is still a critical need for action to reduce the risk of negative health effects from pesticide exposure among Thai farmers.

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2025
• Tom: 76
• Numer: 1
• Opis fizyczny: p.1-9,ref.

Twórcy

autor

Phitsadang N.

• Faculty of Public Health, Chiang Mai University, Thailand

autor

Naksen W.

• Faculty of Public Health, Chiang Mai University, Thailand

autor

Ong-Artborirak P.

• Department of Research and Medical Innovation, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, 3 Thanon Khao, 13000, Bangkok, Thailand

Bibliografia

• 1. Food and Agriculture Organization of the United Nations (FAO). Pesticides use and trade – 1990–2022. FAOSTAT Analytical Briefs, No. 89. Rome: FAO; 2024. ISSN 2709-006X.
• 2. Office of Agricultural Regulation. Statistics of hazardous chemicals imported into Thailand [Internet]. Bangkok: Department of Agriculture, Ministry of Agriculture and Cooperatives; 2021 [cited 2022 July 12] Availablefrom: https://www.doa.go.th/ard/?page_id=386.
• 3. Ong-Artborirak P, Boonchieng W, Juntarawijit Y, Juntarawijit C. Potential effects on mental health status associated with occupational exposure to pesticides among Thai farmers. Int J Environ Res Public Health. 2022;19(15):9654. doi: 10.3390/ijerph19159654.
• 4. Bassil KL, Vakil C, Sanborn M, Cole DC, Kaur JS, Kerr KJ. Cancer health effects of pesticides: systematic review. Can Fam Physician. 2007;53(10):1704-1711.
• 5. Cavalier H, Trasande L, Porta M. Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward. Int J Cancer. 2023;152(5):879-912. doi: 10.1002/ijc.34300.
• 6. Gerken J, Vincent GT, Zapata D, Barron IG, Zapata I. Comprehensive assessment of pesticide use patterns and increased cancer risk. Front. Cancer Control Soc. 2024;2:1368086. doi: 10.3389/fcacs.2024.1368086.
• 7. Daghagh Yazd S, Wheeler SA, Zuo A. Key risk factors affecting farmers’ mental health: a systematic review. Int J Environ Res Public Health. 2019;16(23):4849. doi: 10.3390/ijerph16234849.
• 8. Khan N, Kennedy A, Cotton J, Brumby S. A pest to mental health? Exploring the link between exposure to agrichemicals in farmers and mental health. Int J Environ Res Public Health. 2019;16(8):1327. doi: 10.3390/ijerph16081327.
• 9. Petit P, Gondard E, Gandon G, Moreaud O, Sauvée M, Bonneterre V. Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study. Eur J Epidemiol. 2024;39(3):271-287. doi: 10.1007/s10654-023-01079-0 [published correction appears in Eur J Epidemiol.2024;39(5):569. doi: 10.1007/s10654-024-01116-6].
• 10. Yan D, Zhang Y, Liu L, Yan H. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Sci Rep. 2016;6:32222. doi: 10.1038/srep32222.
• 11. Zaganas I, Kapetanaki S, Mastorodemos V, Kanavouras K, Colosio C, Wilks MF, et al. Linking pesticide exposure and dementia: what is the evidence? Toxicology.2013;307:3-11. doi: 10.1016/j.tox.2013.02.002.
• 12. GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):88-106. doi: 10.1016/S1474-4422(18)30403-4.
• 13. World Health Organization (WHO). WHO mortality database: Alzheimer and other dementias [Internet]. Geneva: WHO; 2024 [cited 2024 July 12] Available from: https://platform.who.int/mortality/themes/themedetails/topics/indicator-groups/indicator-group-details/MDB/alzheimer-and-other-dementias.
• 14. Kelley BJ, Petersen RC. Alzheimer’s disease and mild cognitive impairment. Neurol Clin. 2007;25(3):577-609. doi: 10.1016/j.ncl.2007.03.008.
• 15. Finhler S, Marchesan GP, Corona CF, Nunes AT, De Oliveira KCS, de Moraes AT, et al. Influence of pesticide exposure on farmers’ cognition: a systematic review. J Neurosci Rural Pract. 2023;14(4):574-581. doi: 10.25259/JNRP_58_2023 .
• 16. Aloizou AM, Siokas V, Vogiatzi C, Peristeri E, Docea AO, Petrakis D, et al. Pesticides, cognitive functions and dementia: A review. Toxicol Lett. 2020;326:31-51. doi: 10.1016/j.toxlet.2020.03.005.
• 17. Kim UJ, Hong M, Choi YH. Environmental pyrethroid exposure and cognitive dysfunction in U.S. older adults: the NHANES 2001-2002. Int J Environ Res Public Health. 2021;18(22):12005. doi: 10.3390/ijerph182212005.
• 18. Paul KC, Ling C, Lee A, To TM, Cockburn M, Haan M, et al. Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans. Environ Res. 2018;160:132-139. doi: 10.1016/j.envres.2017.09.017.
• 19. Baldi I, Gruber A, Rondeau V, Lebailly P, Brochard P, Fabrigoule C. Neurobehavioral effects of long-term exposure to pesticides: results from the 4-year follow-up of the PHYTONER study. Occup Environ Med. 2011;68(2):108-115. doi: 10.1136/oem.2009.047811.
• 20. Blanc-Lapierre A, Bouvier G, Gruber A, Leffondré K, Lebailly P, Fabrigoule C, et al. Cognitive disorders and occupational exposure to organophosphates: results from the PHYTONER study. Am J Epidemiol. 2013;177(10):1086-1096. doi: 10.1093/aje/kws346.
• 21. Corral SA, de Angel V, Salas N, Zúñiga-Venegas L, Gaspar PA, Pancetti F. Cognitive impairment in agricultural workers and nearby residents exposed to pesticides in the Coquimbo Region of Chile. Neurotoxicol Teratol. 2017;62:13-19. doi: 10.1016/j.ntt.2017.05.003.
• 22. Ramírez-Santana M, Zúñiga-Venegas L, Corral S, Roeleveld N, Groenewoud H, van der Velden K, et al. Association between cholinesterase’s inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Environ Res. 2020;186:109539. doi: 10.1016/j.envres.2020.109539.
• 23. Kim JY, Park S, Kim SK, Kim CS, Kim TH, Min SH, et al. Pesticide exposure and cognitive decline in a rural South Korean population. PLoS One. 2019;14(4):e0216310. doi: 10.1371/journal.pone.0216310.
• 24. Steenland K, Wesseling C, Román N, Quirós I, Juncos JL. Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica. Environ Res. 2013;120:96-101. doi: 10.1016/j.envres.2012.08.014.
• 25. Setyopranoto I, Gofir A, Rahardjo LP, Panggabean AS, Dwianingsih EK, Setyaningsih I, et al. Association of pesticide exposure with cognitive function in farmers. Eur Neurol. 2023;86(5):305-314. doi: 10.1159/000530899.
• 26. Wongta A, Hongsibsong S, Xu ZL, Chantara S, Pattarawarapan M, Sapbamrer R, et al. The relationship of organophosphate pesticide exposure and cognitive decline among residents of an agricultural area in northern Thailand. J Health Res. 2023;37(6):372-379. doi: 10.56808/2586-940X.1035.
• 27. Chittrakul J, Sapbamrer R, Hongsibsong S. Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators. Front Public Health.2022;10:1060284. doi: 10.3389/fpubh.2022.1060284.
• 28. Fuhrimann S, Staudacher P, Lindh C, van Wendel de Joode B, Mora AM, Winkler MS, et al. Variability and predictors of weekly pesticide exposure in applicators from organic, sustainable and conventional smallholder farms in Costa Rica. Occup Environ Med. 2020;77(1):40-47. doi: 10.1136/oemed-2019-105884.
• 29. Fuhrimann S, Farnham A, Staudacher P, Atuhaire A, Manfioletti T, Niwagaba CB, et al. Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda. Environ Int. 2021;152:106477. doi: 10.1016/j.envint.2021.106477.
• 30. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-699. doi: 10.1111/j.1532-5415.2005.53221.x [published correction appears in J Am Geriatr Soc. 2019;67(9):1991.doi: 10.1111/jgs.15925].
• 31. Hemrungrojn S. Montreal cognitive assessment (MoCA) [Internet]. Canada: MoCA Test Inc.; 2021. [cited 2024 Sep 8] Available from: https://mocacognition.com.
• 32. Tangwongchai S, Phannasathit M, Charernboon T, Akkayagorn L, Hemrungrojn S, Phanthumchinda, et al. The validity of Thai version of the Montreal Cognitive Assessment (MoCA-T). Dement Neuropsychol,2009;3(2):172.
• 33. Rossetti HC, Lacritz LH, Cullum CM, Weiner MF. Normative data for the Montreal Cognitive Assessment (MoCA) in a population-based sample. Neurology. 2011;77(13):1272-1275. doi: 10.1212/WNL.0b013e318230208a.
• 34. Wen L, Miao X, Ding J, Tong X, Wu Y, He Y, et al. Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment. Front Nutr. 2023;10:1113099. doi: 10.3389/fnut.2023.1113099.
• 35. Kim JH, Kim J, Cha ES, Ko Y, Kim DH, Lee WJ. Work-related risk factors by severity for acute pesticide poisoning among male farmers in South Korea. Int J Environ Res Public Health. 2013;10(3):1100-1112. doi: 10.3390/ijerph10031100.
• 36. Sapbamrer R, Kitro A, Panumasvivat J, Assavanopakun P. Important role of the government in reducing pesticide use and risk sustainably in Thailand: Current situation and recommendations. Front Public Health. 2023;11:1141142. doi: 10.3389/fpubh.2023.1141142.
• 37. Kafle S, Vaidya A, Pradhan B, Jørs E, Onta S. Factors associated with practice of chemical pesticide use and acute poisoning experienced by farmers in Chitwan District, Nepal. Int J Environ Res Public Health. 2021;18(8):4194. doi: 10.3390/ijerph18084194.
• 38. Sookhtanlou M, Allahyari MS, Surujlal J. Health risk of potato farmers exposed to overuse of chemical pesticides in Iran. Saf Health Work. 2022;13(1):23-31. doi: 10.1016/j.shaw.2021.09.004.
• 39. Baltazar MT, Dinis-Oliveira RJ, de Lourdes Bastos M, Tsatsakis AM, Duarte JA, Carvalho F. Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases – a mechanistic approach. Toxicol Lett. 2014;230(2):85-103. doi: 10.1016/j.toxlet.2014.01.039.
• 40. Julayanont P, Tangwongchai S, Hemrungrojn S, Tunvirachaisakul C, Phanthumchinda K, Hongsawat J, et al. The Montreal Cognitive Assessment-Basic: A Screening Tool for Mild Cognitive Impairment in Illiterate and Low-Educated Elderly Adults. J Am Geriatr Soc. 2015;63(12):2550-2554. doi: 10.1111/jgs.13820.

Identyfikatory

DOI

10.32394/rpzh/200912