Activation of Alpha 7 nicotinic acetylcholine receptors against cognitive and sensorimotor gating deficits in animal model of schizophrenia

• Autorzy: Potasiewicz A. , Nikiforuk A. , Holuj M. , Popik P.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Alpha 7 nicotinic acetylcholine receptors(α7 nAChRs) are involved in the regulation of cognitive processes. Furthermore, it has been suggested that α7 nAChRs might be implicated in the pathophysiology of schizophrenia. Hence, selective activation of α7 nAChRs is considered to be a potential therapeutic strategy aimed at ameliorating cognitive dysfunctions associated with schizophrenia. Preclinical data indicated that orthosteric ligands, like the partial α7 nAChR agonist, A582941, produced procognitive effects, but little is known about efficacy of this compound in animal models of schizophrenia. The aim of present study was to evaluate the efficacy of A582941 against MK-801- induced schizophrenia-like deficits in rats. Prepulse inhibition of startle response test (PPI), discrete paired-trial delayed alternation task in a T-maze and five-choice serial reaction time task (5-CSRTT) were employed in this study. RESULTS: A582941 reversed the sensorimotor gating and working memory impairment evoked by MK-801 as assessed in the PPI test and T-maze, respectively. However, this compound did not affect the rats’ attentional performance in the 5-CSRTT. CONCLUSIONS: The present study demonstrates the beneficial effects of α7 nAChRs agonist on sensorimotor gating and some aspects of cognition in rats tested in impaired conditions. Therefore, our results support the notion that α7 nAChRs may constitute a useful targets for procognitive therapy in schizophrenia. This study was supported by the Polish National Science Centre grant NCN 2012/07/B/NZ/01150 and statutory funds from the Institute of Pharmacology, Polish Academy of Sciences (Krakow, Poland). Agnieszka Potasiewicz is a holder of scholarship from the KNOW sponsored by Ministry of Science and Higher Education, Republic of Poland.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S54-S55

Twórcy

autor

Potasiewicz A.

• Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

autor

Nikiforuk A.

• Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

autor

Holuj M.

• Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

autor

Popik P.

• Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland