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2015 | 18 | 4 |
Tytuł artykułu

Suitability of using serum hialuronic acid concentrations in the diagnosis of canine liver fibrosis

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
There are multiple dynamic changes associated with the metabolism of the extracellular matrix (ECM) which occur in the course of liver fibrosis. Therefore, the evaluation of parameters reflecting the deposition of ECM, the activity of myofibroblasts and the synthesis and degradation of collagen may aid in the diagnosis of liver fibrosis. Hyaluronic acid is considered to be a marker of ECM deposition. It is a glycosaminoglycan synthesized by hepatic stellate cells and degraded by hepatic sinusoidal endothelial cells. The aim of this study was to evaluate the concentration of hyaluronic acid in dogs with different degrees of liver fibrosis. The study was carried out on 29 dogs with liver disease. A core needle biopsy of the liver was performed in order to assess the degree of hepatic inflammation. Then, hyaluronic acid serum concentrations were measured. The dogs were divided into five groups based on the histopathological examination and the evaluation of the degree of hepatic fibrosis. The study showed that serum hyaluronic acid concentrations were low in patients with first stage liver fibrosis and in controls, while they were twice as high as control values in the group of dogs with second stage liver fibrosis. These concentrations were three-fold greater than control values in patients with third stage liver fibrosis, and seven-fold greater in patients with liver cirrhosis. Based on the results, it was concluded that serum hyaluronic acid is a useful marker of liver fibrosis and may aid in determining the degree of its advancement.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
4
Opis fizyczny
p.873-878,fig.,ref.
Twórcy
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
Bibliografia
  • Afdhal NH (2004) Biopsy or biomarkers: is there a gold standard for diagnosis of liver fibrosis? Clin Chem 50: 1299-1300.
  • Baranova A, Lal P, Birerdinc A, Younossi ZM (2011) Non-invasive Markers for Hepatic Fibrosis. BMC Gastroenterol 11: 91.
  • Baszczuk A, Kęsy L, Kopczyński Z (2012) The value of laboratory tests in the diagnosis of liver fibrosis. J of Med Sci 81: 175-181.
  • Błazik E, Durlik M (2010) Mechanizmy włóknienia wątroby i metody ich oceny. Med Sci Rev Hepatol 10: 25-29.
  • Fernandez-Varo G, Jimenz W (2011) Non-invasive markers of liver fibrosis. Europ Gastr & Hepatol Rev 7: 93-96.
  • Friedman SL (2008) Hepatic fibrosis – overview. Toxicology 254: 120-129.
  • Goodman ZD (2007) Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 47: 598-607.
  • Guechot J, Laudat A, Loria A, Serfaty L, Poupon R, Giboudeau J (1996) Diagnostic accuracy of hyaluronan and type III procollagen amino-terminal peptide serum assays as markers of liver fibrosis in chronic viral hepatitis C evaluated by ROC curve analysis. Clin Chem 42: 558-563.
  • Guechot J, Poupon RE, Poupon R (1995) Serum hyaluronate as a marker of liver fibrosis. J Hepatol 22: 103-106.
  • Guechot J, Serfaty L, Bonnand AM, Chazouillmres O, Poupon RE, Poupon R (2000) Prognostic value of serum hyaluronan in patients with compensated HCV cirrhosis. J Hepatol 32: 447-452.
  • Gutkowski K, Kamińska E, Pluta A (2007) Rola diagnostyki nieinwazyjnej w ocenie zaawansowania procesu włóknienia wątroby. Gastroenterologia Polska 14: 363-367.
  • Kanemoto H, Ohno K, Sakai M, Nakashima K, Takahashi M, Fujino Y, Tsujimoto H (2009) Blood hyaluronic acid as a marker for canine cirrhosis. J Vet Med Sci 71: 1251-1254.
  • Korner T, Kropf J, Gressner AM (1996) Serum laminin and hyaluronan in cirrhosis: markers of progression with high prognostic value. J Hepatol 25: 684-688.
  • Laurent TC, Fraser JR (1992) Hyaluronan. FASEB J 6: 2397-2404.
  • Pinzani M, Macias-Barragan J (2010) Update on the pathophysiology of liver fibrosis. Expert Rev Gastroenterol Hepatol 4: 459-472.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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