Effect of inhibitors of slow calcium current on resting calcium efflux from cat papillary muscles

• Autorzy: Prokopczuk A. , Pytkowski B.
• Języki publikacji: EN

Abstrakty

EN

Prokopczuk A. and Pytkowski В.: Effect of inhibitors of slow calcium current on resting calcium efflux from cat papillary muscles. Acta physiol, pol., 1989, 40 (5-6): 564-568. Examination of influence of divalent cations (Co²⁺, Ni ²⁺, Mn²⁺ and organic blockers (verapamil and D600) on calcium efflux from resting mammalian myocardium shows that they either inhibit or increase transiently 45Ca²⁺ efflux, depending on the site of action. It seems that those agents whose sites of action are limited to the sarcolemma inhibit Ca²⁺ efflux. Co²⁺, Ni²⁺, verapamil and D600 belong to this group. Mn²⁺ ions which act also apparently on intracellular structures increase transiently Ca²⁺ efflux. Such a finding illustrates a diversity in mechanisms of action in a group of agents generally classified as calcium channel blockers.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 5-6
• Opis fizyczny: p.564-568,fig.,ref.

Twórcy

autor

Prokopczuk A.

• Department of Clinical Physiology, Postgraduate Centre of Medical Education, Warsaw, Poland

autor

Pytkowski B.

• Department of Clinical Physiology, Postgraduate Centre of Medical Education, Warsaw, Poland

Bibliografia

• 1. Delahayes, J. F. (1975) Depolarization-induced movement of Mn²⁺ across the cell membrane in the guinea-pig myocardium. Its effect on mechanical response. Circulation Res. 36. 713-718.
• 2. Fleckenstein, A. (1983) History of calcium antagonists. Cir. Res. 52 (Suppl. I) 113-116.
• 3. Kohlhardt, M., Bauer, B., Krause, H., Fleckenstein, A. (1972) Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors. Pflügers Arch. 335. 309-322.
• 4. Kohlhardt, M., Bauer, B., Krause, H., Fleckenstein, A. (1973) Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni, Co and Mn ions. Pflügers Arch. 338. 115-123.
• 5. Lee, K. S., Tsien, K. W. (1983) Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302. 790-794.
• 6. Lewartowski, B., Prokopczuk, A., Pytkowski B. (1978) Effect of inhibitors of slow calcium current on rested state contractions of papillary muscles and post rest contractions of atrial muscle of the cat and rabbit hearts. Pflügers Arch. 277. 167.
• 7. Mc Donald, T., Pelzer D., Trautwein, W. (1981) Does the calcium current modulate the contraction of the accompanying beat? A study of E-C coupling in mammalian ventricular muscle using cobalt ions. Circ. Res. 49. 576-583.
• 8. Nawrath, H., Ten Eick, R. E., Mc Donald, T. F., Trautwein, W. (1977) On the mechanism underlying the action of D600 on slow inward current and tension in mammalian myocardium. Circ. Res. 40. 408-414.
• 9. Reuter, H., Seitz, N. (1968) The dependence of calcium efflux from cardiac muscle on temperature and external ion composition., J. Physiol. 195. 451-470.
• 10. Vierling, W., Reiter, M. (1979) An intracellular induced positive inotropic effect of manganese in guinea-pig ventricular myocardium. Naunyn-Schmiedeberg’s Arch. Pharmacol. 306. 249-253.