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1989 | 40 | 5-6 |
Tytuł artykułu

Effect of calmodulin inhibitors on rat and guinea pig myocardial contractility

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Laptev, В. L, Prokopieva, V. D., Afanasiev, S. A. and Larionov, N. P. Effect of calmodulin inhibitors on rat and guinea pig myocardial contractility. Acta Physiol. Pol., 1989, 40(5-6): 511-519. The effects of phenothiazine drugs with different affinities for calmodulin (trifluoperazine, frenolone, majeptile and aminazine) on the contractility of rat and guinea pig papillary muscles were studied. The phenothiazine-induced changes in the contraction-relaxation parameters were shown to correlate with the degree of calmodulin inhibition. These parameters are relaxation-onset index, relaxation index and terminal relaxation index in rats, and relaxation index and maximal developed tension in guinea pigs. An essential role of calmodulin in myocardium relaxation in both animal species is postulated.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.511-519,fig.,ref.
Twórcy
autor
  • Tomsky Research Center, Institute of Cardiology, USSR Academy of Medical Sciences, Tomsk, USSR
  • Tomsky Research Center, Institute of Cardiology, USSR Academy of Medical Sciences, Tomsk, USSR
  • Tomsky Research Center, Institute of Cardiology, USSR Academy of Medical Sciences, Tomsk, USSR
  • Tomsky Research Center, Institute of Cardiology, USSR Academy of Medical Sciences, Tomsk, USSR
Bibliografia
  • 1. Aass, H., Skomedal, T., Osnes, J-B. (1983) Effects of trifluoperazine on ß-adrenergic responses of rat papillary muscle: related to calmodulin? Acta Pharmacol. Toxicol. 53, 265-274.
  • 2. Afanasiev, S. A., Laptev, В. I., Prokopieva, V. D., Larionov, N. P. (1986) The investigation of aminazine protective effect during ischaemia and perfusion of isolated heart. Biol. Sci. 3. 25-29 (in Russian).
  • 3. Baldenkov, G. N., Menshikov, M. Y., Feoktistov, I. A., Tkachuk, V. A. (1985) Effects of nurotropic compounds on calmodulin- and troponin C-dependent processes. Biochemiya 50. 1141-1150 (in Russian).
  • 4. Caroni, P., Carafoli, E. (1981) The Ca-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification. J. Biol. Chem. 256,3263-3270.
  • 5. Caroni, P., Carafoli, E. (1983) The regulation of the Na⁺ /Ca²⁺ -exchanger of heart sarcolemma. Eur. J. Biochem. 132. 451-460.
  • 6. Huerta-Bahena, Y., Villalobos-Molina, R., Garcia-Saius, G. A. (1982) Trifluoperazine and chlorpromazine antagonise alpha 1- but not alpha 2-adrenergic effects. Mofec. Pharm. 23. 67-70.
  • 7. Kapelko, V. I., Gorina, M. S. (1986) Effect of low sodium perfusion and phrenolone on the contractile function of the isolated cardiac muscle. Physiol. Journ. 32.39-43 (in Russian).
  • 8. Kapelko, V. I., Gorina, M. S., Menshikov, M. Y., Tkachuk V. A. (1985) Effect of calmodulin inhibitors on myocardial contraction and relaxation. Bull. Exp. Biol. Med. 100. 34-36 (in Russian).
  • 9. Lamers, J. M. J. (1985) Calcium transport system in cardiac sarcolemma and their regulation by the second messengers cyclic-АМР and calcium-calmodulin. Gen. Physiol. Biophys. 4. 143-154.
  • 10. Lopaschuk, G., Richter, B., Katz, S. (1980) Characterization of calmodulin effects on calcium transport in cardiac microsomes enriched in sarcoplasmic reticulum. Biochemistry 19. 5603-5607.
  • 11. Meerson, F. Z., Kapelko, V. I. (1973) The role of the connection between the force of contraction and the velocity of relaxation of the myocardium in the adaptation of the heart to increasing load. Cardiology 2. 19-30 (in Russian).
  • 12. Prokopieva, V. D., Barannic, I. V., Roshepkin, V. Z., Larinov, N. P. (1984) The influence of phenothiazines on the sarcoplasmic retriculum Ca-ATPase from skeletal and cardiac muscles. Biochem. Lnt. 8. 843-850.
  • 13. Pruneau, D., Meinguy Y., Rou, F. (1984) Trifluoperazine antagonises postsynaptic α₁ - but not α₂-adrenoreceptor-mediated pressor responses in the rat. Europ. G. Pharmacol. 105, 343-347.
  • 14. Siegel, P.K.S., McNeilly, J.H. (1982) Positive inotropic responses in cardiac muscles: influence of stimulation frequency and species. Can. J. Physiol. Pharmacol. 60. 33-40.
  • 15. Sul, H. S., Cooper, P. H., Mecullough, T. E., Picrett-Gies, C. A., Angelos, K. L., Walsh, D. A. (1981) Regulation of cardiac phosphorylase kinase. Protein phosphoryl. Book A. 343-355.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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