Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview

• Autorzy: Khan N. , Tamboli E. T. , Sharma V. K. , Kumar S.

Warianty tytułu

PL

Profil fitochemiczny i farmakologiczny Nothapodytes nimmoniana. Przegląd

• Języki publikacji: EN

Abstrakty

EN

Nothapodytes nimmoniana (J. Graham) (Icacinaceae), commonly known as Amruta is found in India particularly in Maharashtra, Goa, Kerala, Assam, Jammu and Kashmir as well as Tamilnadu areas. It is an important medicinal plant, the major source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, antimalarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anaemia. Camptothecin is still not synthesized, therefore, its production entirely depends on natural sources. N. nimmoniana is one such plant which yields contain camptothecin in significantly high amount. The plant is gaining international recognition due to its diversified medicinal uses. It is subjected to excessive harvest. It has been categorized as a vulnerable and endangered plant. The present review encompasses the phytochemical, analytical, pharmacological, biotechnological, and other specific aspects of N. nimmoniana.

PL

Nothapodytes nimmoniana (J. Graham) (Icacinaceae), powszechnie znana jako Amruta, rośnie w Indiach, szczególnie w prowincjach Maharashtra, Goa, Kerala, Assam, Dżammu i Kaszmir, a także na niektórych obszarach Tamilnadu. Jest jedną z ważnych roślin leczniczych, głównym źródłem silnego alkaloidu, kamptotecyny, mającej szerokie spektrum działania: przeciwnowotworowe, anty-HIV, antymalaryczne, antybakteryjne, przeciwutleniające, przeciwzapalne, przeciwgrzybicze. Znajduje również zastosowanie w leczeniu anemii. Jak dotąd kamptotecyna nie została zsyntetyzowana, dlatego jej produkcja całkowicie zależy od źródeł naturalnych. N. nimmoniana jest jedną z roślin zawierających duże ilości kamptotecyny. Zyskała ona międzynarodowe uznanie dzięki szerokiemu spektrum zastosowań, co powoduje zwiększenie jej eksploatacji. Z tego powodu została uznana za gatunek zagrożony. Poniższy przegląd obejmuje badania fitochemiczne, analityczne, farmakologiczne, biotechnologiczne i inne prowadzone nad gatunkiem N. nimmoniana.

Słowa kluczowe

EN

phytochemistry; pharmacology; Nothapodytes nimmoniana; Icacinaceae; camptothecin; medicinal property; human disease; treatment

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2013
• Tom: 59
• Numer: 1
• Opis fizyczny: p.53-66,fig.,ref.

Twórcy

autor

Khan N.

• Dr.K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar 201204 U.P., India

autor

Tamboli E. T.

• Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, 110062 New Delhi, India

autor

Sharma V. K.

• Dr.K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar 201204 U.P., India

autor

Kumar S.

• Dr.K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar 201204 U.P., India

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