Intensification of permethrin activity by alpha scorpion toxin-electrophysiological studies on insect nervous system

• Autorzy: Jankowska M. , Stankiewicz M. , Wojnarowska K. , Dabrowski M. , Nowak W.
• Języki publikacji: EN

Abstrakty

EN

Insecticide permethrin causes paralysis of insects by modification of membrane sodium channel (VGNa). It binds to site 7 on VGNa which shows positive allosteric interaction with site 3 for a-toxin from the venom of the scorpion. Alpha toxin accelerates depolarizing effect of permethrin on insect (cockroach) isolated axon. We assumed that the interaction between toxin and permethrin will be observed also on the cockroach whole nervous chain activated by mechanostimulation of cercus. In toxin presence the activity of chain observed after permethrin was higher than after permethrin alone, decreased slower and often salves of spontaneus discharges appeared. Such results correspond well to observations performed on locomotor activity of the cockroach. Alpha toxin accelerated insect paralysis induced by permethrin.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.332

Twórcy

autor

Jankowska M.

• Faculty of Biology and Enviromental Protection, Department of Biophysics, Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland

autor

Stankiewicz M.

• Faculty of Biology and Enviromental Protection, Department of Biophysics, Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland

autor

Wojnarowska K.

• Faculty of Biology and Enviromental Protection, Department of Biophysics, Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland

autor

Dabrowski M.

• Faculty of Biology and Enviromental Protection, Department of Biophysics, Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland
• Faculty of Physics, Astronomy and Informatics. Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland

autor

Nowak W.

• Faculty of Physics, Astronomy and Informatics. Institute of Physics, Nicolaus Copernicus University in Torun, Torun, Poland