Identification of factors modulating oligodendrocyte precursor cells differentiation and maturation

• Autorzy: Zawadzka M.
• Języki publikacji: EN

Abstrakty

EN

Remyelination is a regenerative process, driven by oligodendrocyte precursors (OPC), resulting in new myelin sheaths production and restoring to axons that have been demyelinated as a result of oligodendrocyte death. An understanding of the mechanisms that control the response of OPCs, the CNS multipotent cells, to the pathological conditions and how these cells differentiate and finally support the functional recovery is particularly important for the development of therapeutic strategies targeting both enhancement of endogenous remyelination and tissue regeneration after transplantation of exogenous cells. We have shown that there are two endogenous regenerative processes taking place simultaneously in response to the CNS white matter injury – remyelination and blood vessels reconstruction. Moreover, oligodendrocyte precursor cells differentiate in response to white matter injury giving rise to oligodendrocytes as well as to Schwann cells and the alternative fate is closely depended on the settling of the precursors within the vascular niche. We have found that the vascular niche substantially differs functionally from tissue that does not contain blood vessels by distinct pattern of gene expression coding for the proteins that belong to the key signaling pathways such as BMP, WNT, and Hedgehog. They are differentially involved in alternative differentiation of oligodendrocyte precursors, which suggests that OPCs fate decision depends on the specific microenvironmental clues within injured tissue. Our results show that interactions between cells that respond to damage in nervous system and reside in different areas of tissue, regulate the injury-induced plasticity of OPCs .

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S21

Twórcy

autor

Zawadzka M.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland