Antioxidant, antimicrobial and neutrophil - modulating activities of herb extracts

• Autorzy: Denev P. , Kratchanova M. , Ciz M. , Lojek A. , Vasicek O. , Blazheva D. , Nedelcheva P. , Vojtek L. , Hyrsl P.
• Języki publikacji: EN

Abstrakty

EN

 The present study provides a comprehensive data on the antioxidant, antimicrobial and neutrophil-modulating activities of extracts from six medicinal plants - blackberry (Rubus fruticosus) leaves, chokeberry (Aronia melanocarpa) leaves, hawthorn (Crataegus monogyna) leaves, lady's mantle (Alchemilla glabra) aerial parts, meadowsweet (Filipendula ulmaria) aerial parts and raspberry (Rubus idaeus) leaves. In order to analyze the antioxidant activity of the herbs, several methods (ORAC, TRAP, HORAC and inhibition of lipid peroxidation) were used. Blackberry leaves and meadowsweet extracts revealed the highest antioxidant activities via all methods. All extracts studied blocked almost completely the opsonized zymosan particle-activated ROS production by neutrophils from human whole blood. On the other hand, the effect of extracts on phorbol myristate acetate-activated ROS production was much milder and even nonsignificant in the case of chokeberry leaves. This latter result suggests that extracts (apart from their antioxidative activity) interfere with the signaling cascade of phagocyte activation upstream of the protein kinase C activation. The antimicrobial activity of the investigated extracts against 11 human pathogens was investigated using three different methods. Meadowsweet and blackberry leaves extracts had the highest antimicrobial effect and the lowest minimal inhibiting concentrations (MICs) against the microorganisms tested.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2014
• Tom: 61
• Numer: 2
• Opis fizyczny: p.359-367,fig.,ref.

Twórcy

autor

Denev P.

• Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Laboratory of Biologicaly Active Substances, Plovdiv, Bulgaria

autor

Kratchanova M.

• Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Laboratory of Biologicaly Active Substances, Plovdiv, Bulgaria

autor

Ciz M.

• Institute of Biophysics of the AS CR, Brno, Czech Republic

autor

Lojek A.

• Institute of Biophysics of the AS CR, Brno, Czech Republic

autor

Vasicek O.

• Institute of Biophysics of the AS CR, Brno, Czech Republic

autor

Blazheva D.

• University of Food Technologies, Plovdiv, Bulgaria

autor

Nedelcheva P.

• University of Food Technologies, Plovdiv, Bulgaria

autor

Vojtek L.

• Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic

autor

Hyrsl P.

• Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic

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