Pot marigold (Calendula officinalis L.) - a position in classical phytotherapy and newly documented activities

• Autorzy: Szopa A. , Klimek-Szczykutowicz M. , Jafernik K. , Koc K. , Ekiert H.
• Języki publikacji: EN

Abstrakty

EN

The flower (inflorescence, basket-type inflorescence) of marigold (Calendulae officinalis flos) is a wellknown plant raw material in traditional phytomedicine. It has a complex chemical composition, dominated by flavonoids and terpenoids. Terpenoids are mainly represented by oleanolic acid derivatives specific for this species: triterpenoid saponins – calendulosides A–H and triterpenoid glycosides, so-called calendulaglycosides A and B. Biological activity profiles of the raw material, such as anti-inflammatory, antimicrobial, immunostimulatory and antioxidant properties, determine its use especially in the treatment of dermatological diseases. In addition to spasmolitic, hypolipemic and antidiabetic properties of this flower, scientific studies also demonstrated its cardioprotective, hepatoregenerative, pancreas-regenerating, neuroprotective and even anticancer health-promoting effects. Moreover, C. officinalis is used in the cosmetology and food industry.

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Hortorum Cultus
• Rocznik: 2020
• Tom: 19
• Numer: 3
• Opis fizyczny: p.47-61,fig.,ref.

Twórcy

autor

Szopa A.

• Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul.Medyczna 9, 30-688 Krakow, Poland

autor

Klimek-Szczykutowicz M.

• Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul.Medyczna 9, 30-688 Krakow, Poland

autor

Jafernik K.

• Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul.Medyczna 9, 30-688 Krakow, Poland

autor

Koc K.

• Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul.Medyczna 9, 30-688 Krakow, Poland

autor

Ekiert H.

• Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul.Medyczna 9, 30-688 Krakow, Poland

Bibliografia

• Aghajanyan, A.A., Trchounian, A.H. (2018). Antihyperglicemic properties of the herbal mixture. Chem. Biol., 52(3), 180–186.
• Alexandre, J.T.M., Sousa, L.H.T., Lisboa, M.R.P., Furlaneto, F.A.C., Do Val, D.R., Marques, M., Vasconcelos, H.C., Matos de Melo, I., Leitao, R., Brito G.A.C., Goes, P. (2018). Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats. Clin. Oral Investig., 22(6), 2175–2185. DOI: 0.1007/s00784-017-2308-7
• Anuradha, S.N., Vilashene, G., Lalithambigai, J., Arunkumar, S. (2015). “Cosmeceuticals”: An opinion in the direction of pharmaceuticals. Asian J. Pharm. Clin. Res., 8(2), 64–69.
• Arora, D., Rani, A., Sharma, A. (2013). A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacog. Rev., 7(14), 179. DOI: 10.4103/0973-7847.120520
• Bakó, E., Deli, J., Tóth, G. (2002). HPLC study on the carotenoid composition of Calendula products. J. Bioch. Biophys. Methods, 53, 241–250. DOI: 10.1016/S0165-022X(02)00112-4
• Banakar, S.M., Veerapur, V.P., Thippeswamy, B.S., Jagadeesh, N.V., Gavimath, C.C., Alshehri, Z.S. (2016). Protective effect of Calendula officinalis (L.) flower extract in acetic acid-induced ulcerative colitis in rats. J. Herbs, Spices Med. Plants, 22(3), 225–237. DOI: 10.1080/10496475.2016.1190952
• Basch, E., Bent, S., Foppa, I., Haskmi, S., Kroll, D., Mele, M., Szapary, P., Ulbricht, C., Voa, M., Vora, M., Yong, S. (2006). Marigold (Calendula officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J. Herb. Pharmacother., 6(3–4), 135–159. DOI: 10.1080/J157v06n03_08
• Bingen, H. von (1155). Hildegard von Bingen’s Physica.
• Buzzi, M., Freitas, F. de, Barros Winter, M. de (2016). Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing. J. Wound Care, 25(12), 732–739. DOI: 10.12968/jowc.2016.25.12.732
• Colombo, E., Sangiovanni, E., D’Ambrosio, M., Bosisio, E., Ciocarlan, A., Fumagalli, M., Guerriero A., Harghel P., Dell’Agli, M. (2015). A bio-guided fractionation to assess the inhibitory activity of Calendula officinalis L. on the NF-B driven transcription in human gastric epithelial cells. Evid.-Based Complement. Altern. Med., 2, 727342. DOI: 10.1155/2015/727342
• Corazza, M., Borghi, A., Gallo, R., Schena, D., Pigatto, P., Lauriola, M.M., Guarneri, F., Stngeni, L., Vincenzi, C., Foti, C., Virgili, A. (2014). Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatitis, 70(2), 90–97. DOI: 10.1111/cod.12124
• Cordova, C., Siqueira, I., Netto, C. (2002). Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger. Redox Rep., 7(2), 95–102. DOI: 10.1179/135100002125000325
• CosIng – Cosmetic Ingredient Database. Available: https://ec.europa.eu/growth/sectors/cosmetics/cosing_en [data of access: 06.12.2018].
• Denisow-Pietrzyk, M., Pietrzyk, Ł. (2019). Asteraceae species as potential environmental factors of allergy. Environ. Sci. Pollut. Res. 26(1), 1–11. DOI: 10.1007/s11356-019-04146-w
• Dinda, M., Dasgupta, U., Singh, N., Bhattacharyya, D., Karmakar, P. (2015). PI3K-Mediated proliferation of fibroblasts by Calendula officinalis tincture: Implication in wound healing. Phytother. Res., 29(4), 607–616. DOI: 10.1002/ptr.5293
• Duran, V., Matic, M., Jovanovic, M. (2005). Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int. J. Tissue. React., 27(3), 101–106.
• EFSA – European Food Safety Authority. Available: http://www.efsa.europa.eu/ [data of access: 11.11.2018].
• European Pharmacopoeia 9.0 (2017). European Directorate for the Quality of Medicines, Strasburg.
• EMA – European Medicines Agency. Available: https://www.ema.europa.eu/ [data of access: 06.01.2019].
• ESCOP – European Scientific Cooperative on Phytotherapy. Available: http://escop.com/ [data of access: 20.02.2019].
• Farahpour, M.R. (2014). Antioxidant activity, antinociceptive and anti-inflammatory effects of pot marigold hydroalcoholic extract on experimental animals. Int. J. PharmTech. Res., 6(5), 1640–1646.
• Farmakopea Polska XI (2017). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, Warszawa.
• Faustino, M.V., Pinto, D.C.G.A., Gonçalves, M.J., Salgueiro, L., Silveira, P., Silva, A.M.S. (2018). Calendula L. species polyphenolic profile and in vitro antifungal activity. J. Funct. Foods, 45, 254–267. DOI: 10.1016/j.jff.2018.04.013
• Georgiev, V., Slavov, A., Vasileva, I., Pavlov, A. (2018). Plant cell culture as emerging technology for production of active cosmetic ingredients. Eng. Life Sci., 18(11), 779–798. DOI: 10.1002/elsc.201800066
• German Commission E Monographs, Phytotherapy (1986). Calendula flower (Calendulae flos) [summary of the monograph]. Available: https://buecher.heilpflanzen-welt.de/BGA-Commission-E-Monographs/0043.htm [data of access: 26.01.2019].
• Gilca, M., Tiplica, G.S., Salavastru, C.M. (2018). Traditional and ethnobotanical dermatology practices in Romania and other Eastern European countries. Clin. Dermatol., 36(3), 338–352, DOI: 10.1016/j.clindermatol.2018.03.008
• Grzelak, A., Janiszowska, W. (2002). Initiation and growth characteristics of suspension cultures of Calendula officinalis cells. Plant Cell. Tissue Organ Cult., 71, 29–40. DOI: 10.1023/A:1016553909002
• Hernández-Saavedra, D., Pérez-Ramírez, I.F., Ramos-Gómez, M., Mendoza-Díaz, S., Loarca-Piña, G., Reynoso-Camacho, R. (2016). Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk. Med. Chem. Res., 25(1), 163–172. DOI: 10.1007/s00044-015-1454-1
• Jadoon, S., Karim, S., Hassham, M., Bin, H., Akram, M.R., Khan, A.K., Malik, A., Chen, C., Murtaza, G. (2015). Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity. Oxidative Med. Cell. Longev., 2015, 1–17. DOI: 10.1155/2015/709628
• John, R., Andrabi, K.I., Jan, N. (2017). Calendula officinalis – an important medicinal plant with potential biological properties. Proc. Indian Natl. Sci. Acad., 83(4), 769–787. DOI: 10.16943/ptinsa/2017/49126
• Kaur, J., Sidhu, S., Chopra, K., Khan, M.U. (2016). Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats. Pharm. Biol., 54(12), 2951–2959. DOI: 10.1080/13880209.2016.1195848
• Khalid, K.A., Silva, J.A.T. (2012). Biology of Calendula officinalis Linn.: Focus on pharmacology, biological activities and agronomic practices. Med. Aromat. Plant Sci. Biotechnol. 6, 12–27.
• Kurkin, V.A., Sharova, O.V. (2007). Flavonoids from Calendula officinalis flowers. Chem. Nat. Compd., 43(2), 216–217. DOI: 10.1007/s10600-007-0084-3
• Leach, J.M. (2008). Calendula officinalis and wound healing: a systematic review. Wounds, 20(8), 236–243.
• Legha, M.R., Prasad, K.V., Singh, S.K., Kaur, C., Arora, A., Kumar, S. (2012). Induction of carotenoid pigments in callus cultures of Calendula officinalis L. in response to nitrogen and sucrose levels. Vitr. Cell. Dev. Biol. – Plant, 48(1), 99–106. DOI: 10.1007/s11627-011-9402-3
• Lima, M.R., Lopes, A.P., Martins, C., Brito, G.A.C., Carneiro, V.C., Goes, P. (2017). The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis. Front. Physiol., 8, 1–9. DOI: 10.3389/fphys.2017.00440
• Lohani, A., Mishra, A.K., Verma, A. (2018). Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor. J. Cosmet. Dermatol., 1–8. DOI: 10.1111/jocd.12789
• Lovecka, P., Lipov, J., Thumova, K., Macurkova, A. (2018). Characterization of biologically active substances from Calendula officinalis. Curr. Pharm. Biotechnol., 19, 1167–1174. DOI: 10.2174/1389201019666180226151910
• Miguel, M., Barros, L., Pereira, C., Calhelha, R.C., Garcia, P.A., Castro, M.Á., Santos-Buelga, C., Ferreira, I.C.F.R. (2016). Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves). Food Funct., 7(5), 2223–2232. DOI: 10.1039/c6fo00398b
• Muley, B.P., Khadabadi, S.S., Banarase, N.B. (2009). Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): A review. Trop. J. Pharm. Res., 8(5), 455–465. DOI: 10.4314/tjpr.v8i5.48090
• Neukirch, H., D’Ambrosio, M., Dalla Via, J., Guerriero, A. (2004). Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem. Anal., 15(1), 30–35. DOI: 10.1002/pca.739
• Nicolaus, C., Junghanns, S., Hartmann, A., Murillo, R., Ganzera, M., Merfort, I. (2017). In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J. Ethnopharmacol., 196, 94–103. DOI: 10.1016/j.jep.2016.12.006.
• Nizyński, B., Alsoufi, A.S.M., Pączkowski, C., Długosz, M., Szakiel, A. (2015). The content of free and esterified triterpenoids of the native marigold (Calendula officinalis) plant and its modifications in in vitro cultures. Phytochem. Lett., 11, 410–417. DOI: 10.1016/j.phytol.2014.12.017
• Okoh, O.O., Sadimenko, A.A., Afolayan, A. (2007). The effects of age on the yield and composition of the essential oils of Calendula officinalis. J. Appl. Sci., 7(23), 3806–3810. DOI: 10.3923/jas.2007.3806.3810
• Okuma, C.H., Andrade, T.A.M., Caetano, G.F., Finci, L.I., Maciel, N.R., Topan, J.F., Cefali, L.C., Polizello, A.C.M., Carlo, T., Rogerio, A.P., Spadaro, A.C.C., Isaac, V.L.B., Frade, M.A.C., Rocha-Filho, P.A. (2015). Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing. Eur. J. Pharm. Sci., 71, 62–72. DOI: 10.1016/j.ejps.2015.01.016
• Parente, L.M.L., Souza Lino Jr, R. de, Tresvenzol, L.M.F., Vinaud, M.C., Paula, J.R. de, Paulo, N.M. (2012). Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid.-Based Complement. Altern. Med., 2012, 1–7. DOI: 10.1155/2012/375671
• Paul, S., Rahman, A., Mahmud, M., Uzzal, A., Das, Z. (2018). Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: a comparative approach. J. Adv. Vet. Anim. Res., 4(4), 333. DOI: 10.5455/javar.2017.d229
• Pedram Rad, Z., Mokhtari, J., Abbasi, M. (2019). Preparation and characterization of Calendula officinalis-loaded PCL/gum arabic nanocomposite scaffolds for wound healing applications. Iran. Polym. J., 28(1), 51–63. DOI: 10.1007/s13726-018-0674-x
• Pommier, P., Gomez, F., Sunyach, M.P., D’Hombres, A., Carrie, C., Montbarbon, X. (2004). Phase III randomised trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J. Clin. Oncol., 22(8), 1447–1453. DOI: 10.1200/JCO.2004.07.063
• Preethi, K.C., Kuttan, R. (2009). Wound healing activity of flower extract of Calendula officinalis. J. Basic Clin. Physiol. Pharmacol., 20(1), 73–79. DOI: 10.1515/jbcpp.2009.20.1.73
• Reider, N., Komericki, P., Hausen, B.M., Fritsch, P., Aberer, W. (2001). The seamy side of natural medicines: Contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis, 45(5), 269–272. DOI: 10.1034/j.1600-0536.2001.450503.x
• Ruszkowski, D., Szakiel, A., Janiszowska, W. (2005). Metabolism of [3-3H]oleanolic acid in Calendula officinalis L. root. Acta Physiol. Plant., 25(4), 311–317. DOI: 10.1007/s11738-003-0011-6
• Saffari, E., Mohammad-Alizadeh-Charandabi, S., Adibpour, M., Mirghafourvand, M., Javadzadeh, Y. (2017). Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial. Women Heal., 57(10), 1145–1160. DOI: 10.1080/03630242.2016
• Salehi, B., Anil Kumar, N.V., Şener, B., Sharifi-Rad, M., Kılıç, M., Mahady, G.B., Mehtap, K., Vlaicavljevic, S., Iriti, M., Kobarfard, F., Setzer, W.N., Ayatollahi, S.A., Ata, A., Sharifi-Rad, J. (2018). Medicinal plants used in the treatment of human immunodeficiency virus. Int. J. Mol. Sci., 19(5), 1459. DOI: 10.3390/ijms19051459
• Samochowiec, E., Urbanska, L., Manka, W., Stolarska, E. (1979). Assessment of the action of Calendula officinalis and Echinacea angustifolia extracts on Trichomonas vaginalis in vitro. Wiad. Parazytol., 25(1), 77–81.
• Shafeie, N., Naini, A.T., Jahromi, H.K. (2015). Comparison of different concentrations of Calendula officinalis gel on cutaneous wound healing. Biomed. Pharmacol. J., 8(2), 979–992. DOI: 10.13005/bpj/850
• Shankar, S.M., Bardvalli, S.G., Jyotirmayee, R., Chethana, Bhushan, K., Kumar, S. (2017). Efficacy of Calendula officinalis extract (marigold flower) as an antimicrobial agent against oral microbes: An in vitro study in comparison with chlorhexidine digluconate. J. Clin. Diagnostic Res., 11(10), ZC05-ZC10. DOI: 10.7860/JCDR/2017/29844.10702
• Shivasharan, B.D., Nagakannan, P., Thippeswamy, B.S., Veerapur, V.P., Bansal, P., Unnikrishnan, M.K. (2013). Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington’s disease in rats. Drug Chem. Toxicol., 36(4), 466–473. DOI: 10.3109/01480545.2013.776583
• Singh, M.K., Sahu, P., Nagori, K., Dewangan, D., Alexander, T.K.A., Badwaik, H., Tripathi, D.K. (2011). Organoleptic properties in-vitro and in-vivo pharmacological activities of Calendula officinalis Linn.: An over review. J. Chem. Pharm. Res., 3(4), 655–663.
• Toropova, A.A., Badmaev, N.S., Razuvaeva, Y.G., Nikolaev, S.M., Sambueva, Z.G., Erentueva, A. (2017). Influence of Calendula officinalis extract on the antioxidant and energy status of liver in rats with experimental hepatitis. Eksp. Klin. Farmakol., 80(7), 11–14.
• Tundis, R., Loizzo, M.R., Bonesi, M., Menichini, F. (2015). Potential role of natural compounds against skin aging. Curr. Med. Chem., 22(12), 1515–1538. DOI: 10.2174/0929867322666150227151809
• FDA – U.S. Food & Drug Administration. Available: https://www.fda.gov/ [data of access: 22.01.2019].
• Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Suzuki, T., Kimura, Y. (2006). Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of Marigold (Calendula officinalis) flowers. J. Nat. Prod., 69(12), 1692–1696. DOI: 10.1021/np068016b
• WHO (2002). Monographs on selected medical plants, vol. 2. Geneva.
• Wiktorowska, E., Długosz, M., Janiszowska, W. (2010). Significant enhancement of oleanolic and accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L. Enzyme Microb. Technol., 46, 14–20. DOI: 10.1016/j.enzmictec.2009.09.002
• Xuan, S.H., Kim, G.Y., Yu, J.Y., Kim, J.W., Yang, Y.R., Jeon, Y.H., Jeong, Y.J., Kim, R.A., Park, S.N. (2016). Antioxidant and cellular protective effects against oxidative stress of Calendula officinalis flowers extracts in human skin cells. Appl. Chem. Eng., 27(6), 620–626. DOI: 10.14478/ace.2016.1093
• Xuan, S.H., Park, Y.M., Park, S.N. (2019). Antimelanogenic and antimigration properties of the ethyl acetate fraction of Calendula officinalis flowers on melanoma cells. Photochem. Photobiol., 95(3), 860–866. DOI: 10.1111/php.13064

Identyfikatory

DOI

10.24326/asphc.2020.3.5