Impact of LEP and LEPR gene polymorphisms on functional traits in Polish Holstein-Friesian cattle

• Autorzy: Komisarek J.

Warianty tytułu

PL

Wpływ polimorfizmu w genach LEP i LEPR na cechy funkcjonalne bydła rasy polskiej holsztyńsko-fryzyjskiej

• Języki publikacji: EN

Abstrakty

EN

Five single nucleotide polymorphisms in leptin and leptin receptor genes were analysed for their possible impact on estimating breeding values for somatic cell count score (SCS) in milk, longevity and reproductive traits. Used were 309 active Polish Holstein-Friesian bulls. The LEP-C(-963)T,LEP-Y7F, LEP-R25C, LEP-A80V, and LEPR-T945M genotypes were identified using the PCRRFLP method. For linked leptin mutations, the additional haplotype analysis was performed. The results obtained suggest that three polymorphisms of bovine LEP gene may be associated with nonreturn rate in cows. The most significant effect was found for LEP-A80V. Moreover, the LEPRT945M mutation seemed to be related to the age at first insemination.

PL

Analizowano pięć polimorfizmów w genach leptyny i receptora leptyny pod względem ich wpływu na szacowaną wartość hodowlaną dla zawartości komórek somatycznych w mleku, długowieczności oraz cech reprodukcyjnych. Badania prowadzono w grupie 309 buhajów hodowlanych rasy polskiej holsztyńsko-fryzyjskiej. Genotypy w loci LEP-C(-963)T, LEP-Y7F, LEP-R25C, LEP-A80V i LEPRT945M identyfikowano metodą PCR-RFLP. Dla sprzężonych mutacji w genie leptyny przeprowadzono dodatkową analizę haplotypów. Uzyskane wyniki wskazują, że trzy polimorfizmy w genie LEP mogą być związane ze wskaźnikiem niepowtarzalności rui u krów, przy czym najistotniejszy efekt wykryto dla LEPA80V. Ponadto, mutacja LEPR-T945M może mieć wpływ na wiek pierwszego unasienienia.

Słowa kluczowe

EN

gene polymorphism; functional trait; Polish Holstein-Friesian breed; cattle; polymorphism; reproduction; leptin; leptin receptor gene; breeding value; haplotype

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2010
• Tom: 28
• Numer: 2
• Opis fizyczny: p.133-141,ref.

Twórcy

autor

Komisarek J.

• Department of Cattle Breeding and Milk Production, Poznan University of Life Sciences, Wojska Polskiego 71A, 60-625 Poznan, Poland

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