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2012 | 56 | 2 |

Tytuł artykułu

Changes in cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) nerve structures of the porcine descending colon during proliferative enteropathy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The distribution pattern of CART- like immunoreactive (CART-LI) nerve structures was studied by a double immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP), and inner submucous plexuses (ISP), as well as in the mucosal layer of porcine descending colon under physiological conditions and during proliferative enteropathy (PE). In control animals, CART-LI perikarya have been shown to constitute 3.18 ±0.51%, 3.44 ±0.6%, and 3.33 ±0.72% in MP, OSP, and ISP, respectively. PE caused a decrease in the number of CART - LI neurons in MP and ISP. In OSP, the observed changes were not statistically significant. During PE, the number of CART-LI perikarya amounted to 2.18 ±0.27%, 3.07 ±0.06%, and 0.07 ±0.02% within MP, OSP, and ISP, respectively. Moreover, PE caused an increase in the number of CART-LI nerve fibers in the colonic circular muscle and mucosal layers as well as in MP. This study describes for the first time changes in CART-LI nerve structures of the porcine descending colon during Lawsonia intracellularis infection, and suggests the participation of this neuropeptide in the regulation of gut functions, not only under physiological conditions, but also during pathological processes.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

56

Numer

2

Opis fizyczny

p.199-203,fig.,ref.

Twórcy

autor
  • Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
autor
autor
autor

Bibliografia

  • 1. Arciszewski M.B., Ekblad E.: Effects of vasoactive intestinal peptide and galanin on survival of cultured porcine myenteric neurons. Reg Pept 2005, 125, 185- 192.
  • 2. Ekblad E.: CART in the enteric nervous system. Peptides 2006, 27, 2024-2030.
  • 3. Ellis L.M., Mawe G.M.: Distribution and chemical coding of cocaine -and amphetamine-regulated transcript peptide (CART)-immunorective neurons in the guinea pig bowel. Cell Tissue Res 2003, 312, 265-274.
  • 4. Gonkowski S., Burliński P., Całka J.: Proliferative enteropathy (PE)-induced changes in galanin-like immunoreactivity in the enteric nervous system of the porcine distal colon. Acta Vet (Beograd) 2009, 59, 321- 330.
  • 5. Gonkowski S., Burliński P., Skobowiat C., Majewski M., Arciszewski M.B., Radziszewski P., Całka J.: Distribution of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) nerve structures in the porcine large intestine. Acta Vet Hung 2009, 57, 509-520.
  • 6. Gonkowski S., Kamińska B., Burliński P., Kroll A., Całka J.: The influence of drug-resistant colitis on the number of cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) mucosal nerve fibres of the descending colon in children. Gastroenterology Rev 2009, 4, 147-151.
  • 7. Gunnarsdóttir A., Wierup N., Larsson L.T., Kuhar M.J., Ekblad E.: CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease. Eur J Pediatr Surg 2007, 17, 184-189.
  • 8. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., Hastrup S.: Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998, 393, 72-76.
  • 9. Lawson G.H., Gebhart C.J.: Proliferative enteropathy. J Comp Pat 2000, 122, 77-100.
  • 10. Okumura T., Yamada H., Motomura W., Kohgo Y.: Cocaine- amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotrophin-releasing factor system. Endocrinology 2000, 141, 2854-2860.
  • 11. Pidsudko Z., Kaleczyc J., Majewski M., Łakomy M., Scheuermann D.W., Timmermans J.P.: Differences in the distribution and chemical coding between neurons in the inferior mesenteric ganglion supplying the colon and rectum in the pig. Cell Tissue Res 2001, 303, 147-158.
  • 12. Pidsudko Z., Kaleczyc J., Wąsowicz K., Sienkiewicz W., Majewski M., Zając W., Łakomy M.: Distribution and chemical coding of intramural neurons in the porcine ileum during proliferative enteropathy. J Comp Path 2008, 138, 23-31.
  • 13. Reinshagen M., Patel A., Sottili M., French S., Sternini C., Eysselein V.E.: Action of sensory neurons in an experimental rat colitis model of injury and repair. Am J Physiol 1996, 270, G79-G86.
  • 14. Sandgren K., Lin Z., Svenningsen A.F., Ekblad E.: Vasoactive intestinal peptide and nitric oxide promote survival of adult rat myenteric neurons in culture. J Neurosci Res 2003, 72, 595-602.
  • 15. Tebbe J.J., Ortmann E., Schumacher K., Mönnikes H., Kobelt P., Arnold R., Schäfer M.K.H.: Cocaine- and amphetamine-regulated transcript stimulates colonic motility via central CRF receptor activation and peripheral cholinergic pathways in fed conscious rats. Neurogastroenterol Motil 2004, 16, 489-496.
  • 16. Wierup N., Gunnarsdóttir A., Ekblad E., Sundler F.: Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands. BMC Neurosci 2007, 8, 51 DOI 10.1186/1471-2202-8-51.

Typ dokumentu

Bibliografia

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Identyfikator YADDA

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