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2008 | 68 | 2 |
Tytuł artykułu

Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2). The Ang-1/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH), by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
68
Numer
2
Opis fizyczny
p.147-154,fig.,ref.
Twórcy
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
  • Institute of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Key Laboratory of Cancer Proteomics of Ministry of Health of China, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
autor
  • Institute of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
Bibliografia
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Bibliografia
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bwmeta1.element.agro-e2641916-6f10-4a09-b139-e88d00d56597
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