Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage

• Autorzy: Zhou H. , Tang T. , Guo C. , Zhang H. , Zhong J. , Zheng J. , Luo J. , Lin Y. , Liu W. , Luo W. , Yang Q.
• Języki publikacji: EN

Abstrakty

EN

Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2). The Ang-1/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH), by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2008
• Tom: 68
• Numer: 2
• Opis fizyczny: p.147-154,fig.,ref.

Twórcy

autor

Zhou H.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Tang T.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China
• Institute of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China

autor

Guo C.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Zhang H.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Zhong J.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Zheng J.

• Key Laboratory of Cancer Proteomics of Ministry of Health of China, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China

autor

Luo J.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Lin Y.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Liu W.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Luo W.

• Institute of Integrative Medicine, Xiangya Hospital, Central South University. Changsha, Hunan, People's Republic of China

autor

Yang Q.

• Institute of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China

Uwagi

PL

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