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2017 | 73 | 02 |
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Ostre białaczki u psów - analiza 31 przypadków

Treść / Zawartość
Warianty tytułu
EN
Acute leukemias in dogs: Analysis of 31 cases
Języki publikacji
PL
Abstrakty
EN
The aim of the present study was to analyse epidemiological, cytological, laboratory and clinical data from canine acute leukemia (AL) cases. The study was conducted from 2009 to 2015, and included 2384 dogs undergoing cytological examination in two veterinary practices in Warsaw. The analysis included dogs in which bone marrow cytology revealed acute leukemia, regardless of its subtype. Data on breed, age, sex, as well as clinical signs and results of haematological examination were collected for every dog. Breed predisposition to acute leukemia was calculated by statistical methods on the basis of the theoretical distribution of canine breeds in Poland. Acute leukemia was diagnosed in 31 dogs (24.7%) undergoing bone marrow cytology, that is, in 1.3% of all the dogs examined by cytology during the study period. The disease was diagnosed mainly in adults, and a strong predisposition was found particularly in German shepherds and Golden retrievers. The median duration of clinical signs from the onset to diagnosis was 14 days. The clinical signs were mostly non-specific (apathy, recurrent fever, lack of appetite), whereas lymphadenomegaly or/and splenomegaly were observed more seldom. Hematology revealed neoplastic leukocytosis in 75% of dogs, whereas anemia and trombocytopenia were observed in 86% and 85% of patients, respectively. Regardless of the leukemia subtype, prognosis was poor. In conclusion, it can be stated that according to current knowledge on canine acute leukemias, bone marrow cytology based on routine staining methods is sufficient for correct diagnosis in a vast majority of cases.
Wydawca
-
Rocznik
Tom
73
Numer
02
Opis fizyczny
s.118-123,rys.,tab.,bibliogr.
Twórcy
  • Katedra Patologii i Diagnostyki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa
autor
  • ALAB Plus sp. z o.o., ul. Stępińska 22/30, 00-739 Warszawa
autor
  • Samodzielna Pracownia Epidemiologii i Ekonomiki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa
autor
  • Przychodnia Weterynaryjna "Białobrzeska", ul. Częstochowska 20, 02-344 Warszawa
autor
  • Przychodnia Weterynaryjna "Białobrzeska", ul. Częstochowska 20, 02-344 Warszawa
  • Katedra Patologii i Diagnostyki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa
Bibliografia
  • Adam F., Villiers E., Watson S., Coyne K., Blackwood L.: Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukemia. Vet. Comp. Oncol. 2009, 7, 181-195.
  • Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C.: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 1976, 33, 451-458.
  • Bush B. M. (ed.): Interpretation of Laboratory Results for Small Animal Clinicians. John Wiley and Sons Ltd., London 1995.
  • Comazzi S., Gelain M. E., Bonfanti U., Roccabianca P.: Acute megakaryoblastic leukemia in dogs: a report of three cases and review of the literature. J. Am. Anim. Hosp. Assoc. 2010, 46, 327-335.
  • Comazzi S., Gelain M. E., Martini V., Riondato F., Miniscalco B.: Immunophenotype predicts survival time in dogs with chronic lymphocytic leukemia. J. Vet. Intern. Med. 2011, 25, 100-106.
  • Ferreira H. M. T., Smith S. H., Schwartz A. M., Milne E. M.: Myeloperoxidasepositive acute megakaryoblastic leukemia in a dog. Vet. Clin. Pathol. 2011, 40, 530-537.
  • Gelain M. E., Martini V., Giantin M., Arico A., Poggi A., Aresu L., Riodanto F., Dacasto M., Comazzi S.: CD44 in canine leukemia: Analysis of mRNA and protein expression in peripheral blood. Vet. Immunol. Imunopath. 2014, 159, 91-96.
  • Grindem C. E., Stevens J. B., Perman V.: Morphological classification and clinical and pathological characteristics of spontaneous leukaemia in 17 dogs. J. Am. Anim. Hosp. Assoc. 1985, 21, 219-226.
  • Harvey J. H. (ed.): Hematopoietic neoplasms. Atlas of Veterinary Hematology. J. H. Saunders, Philadelphia 2001, s. 163-184.
  • Hisasue M., Nishimura T., Neo S., Nagashima N., Ishikawa T., Tsuchiya R., Yamada T.: A dog with acute myelomonocytic leukemia. J. Vet. Med. Sci. 2008, 70, 619-621.
  • Joupperi T. A., Bienzle D., Bernreuter D. C., Vernau W., Thrall M. A., McManus P. M.: Prognostic markers for myeloid neoplasms: A comparative review of the literature and goals for future. Vet. Pathol. 2011, 48, 182-197.
  • Matus R. E., Leifer C. E., MacEwen E. G.: Acute lymphoblastic leukemia in the dog: a review of 30 cases. J. Am. Vet. Med. Assoc. 1983, 183, 859-862.
  • McManus P. M.: Classification of myeloid neoplasms: a comparative review. Vet. Clin. Pathol. 2005, 34, 189-212.
  • Miglio A., Antognoni M. T., Miniscalco B., Calvano D., Lepri E., Birettoni F., Mangili V.: Acute undifferentiated leukaemia in a dog. Aust. Vet. J. 2014, 92, 499-503.
  • Mylonakis M. E., Kritsepi-Konstantinou M., Vernau W., Valli V. E., Pardali D., Koutinas A. F.: Presumptive pure erythroid leukemia in a dog. J. Vet. Diagn. Invest. 2012, 24, 1004-1007.
  • Novacco M., Comazzi S., Marconato L., Cozzi M., Stefanello D., Aresu L., Martini V.: Prognostic factors in canine acute leukaemias: a retrospective study. Vet. Comp. Oncol. doi: 10.1111/vco.12136, 2015.
  • Sergeant E. S. G.: Epitools Epidemiological Calculators. AusVet Animal Health Services and Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease. 2015, Available at: http://epitools.ausvet.com.au
  • Stokol T., Schaefer D., Shuman M., Belcher N., Dong L.: Alkaline phosphatase is a useful cytochemical marker for the diagnosis of acute myelomonocytic and monocytic leukemia in the dog. Vet. Clin. Pathol. 2015, 44, 79-93.
  • Tasca S., Carli E., Caldin M., Menegazzo L., Furlanello T., Gallego L. S.: Hematologic abnormalities and flow cytometric immunophenotyping results in dogs with hematopoietic neoplasia: 210 cases (2002-2006). Vet. Clin. Pathol. 2009, 38, 2-12.
  • Tasca S., Furlanello T., Caldin M.: High serum and urine lysozyme levels in a dog with acute myeloid leukemia. J. Vet. Diagn. Invest. 2010, 22, 111-115.
  • Tomiyasu H., Fujino Y., Takahashi M., Ohno K., Tsujimoto H.: Spontaneous acute erythroblastic leukemia (AML-M6Er) in a dog. J. Small Anim. Pract. 2011, 52, 445-447.
  • Vail D. M., Young K. M.: Canine lymphoma and lymphoid leukaemia. Withrow&MacEwen’s Small Animal Clinical Oncology. Saunders Elsevier, St. Louis 2007, s. 699-768.
  • Valentini F., Tasca S., Gavazza A., Lubas G.: Use of CD9 and CD61 for the characterization of AML-M7 by flow cytometry in a dog. Vet. Comp. Oncol. 2011, 10, 312-318.
  • Vardiman J. W., Thiele J., Arber D. A., Brunning R. D., Borowitz M. J., Porwit A., Harris N. L., Le Beau M. M., Hellström-Lindberg E., Tefferi A., Bloomfield C. D.: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114, 937-951.
  • Vernau W., Moore P. F.: An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction. Vet. Immunol. Immunopathol. 1999, 69, 145-164.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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