Autonomic drugs in the treatment of canine and feline glaucoma – Part I: Medications that lower intraocular pressure by increasing the outflow of aqueous humour

• Autorzy: Maslanka T.
• Języki publikacji: EN

Abstrakty

EN

One characteristic of the most common types of glaucoma is increased intraocular pressure (IOP), which has a damaging effect on optic nerve axons, leading to progressive loss of retinal ganglion cells. Therefore, ocular hypotensive drugs are the mainstay of pharmacological therapy for glaucoma. This review article, which is the first part of a two-part series, is dedicated to autonomic drugs which lower IOP by increasing the outflow of aqueous humour. These agents are subdivided into two groups: (a) drugs that lower IOP by increasing the trabecular outflow and the uveoscleral outflow (i.e. nonselective adrenergic agonists), and (b) medications that lower IOP by opening of the drainage angle and by increasing the conventional outflow via the trabecular outflow (i.e. parasympathomimetics). This paper summarizes the current state of knowledge on the mechanism of action of these drugs and their effect on IOP in dogs and cats. Moreover, it discusses possible undesirable side effects of these medications and presents the current ideas about their role and position in the medical management of glaucoma in small animals.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2014
• Tom: 17
• Numer: 4
• Opis fizyczny: p.741–752, fig.,ref.

Twórcy

autor

Maslanka T.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland

Bibliografia

• Albracht DC, LeBlanc RP, Cruz AM, Lamping KA, Siegel LI, Stern KL, Kelley EP, Stoecker JF (1993) A double-masked comparison of betaxolol and dipivefrin for the treatment of increased intraocular pressure. Am J Ophthalmol 116: 307-313.
• Alexander DW, Berson FG, Epstein DL (1988) A clinical trial of timolol and epinephrine in the treatment of primary open-angle glaucoma. Ophthalmology 95: 247-251.
• Alm A, Nilsson SF (2009) Uveoscleral outflow - a review. Exp Eye Res 88: 760-768.
• Alvarado JA, Murphy CG, Franse-Carman L, Chen J, Underwood JL (1998) Effect of beta-adrenergic agonists on paracellular width and fluid flow across outflow pathway cells. Invest Ophthalmol Vis Sci 39: 1813-1822.
• Anderson DR, Davis EB (1975) Sensitivities of ocular tissues to acute pressure-induced ischemia. Arch Ophthalmol 93: 267-274.
• Anderson JA, Davis WL, Wei CP (1980) Site of ocular hydrolysis of a prodrug, dipivefrin, and a comparison of its ocular metabolism with that of the parent compound, epinephrine. Invest Ophthalmol Vis Sci 19: 817-823.
• Anderson L, Wilson WS (1990) Inhibition by indomethacin of the increased facility of outflow induced by adrenaline. Exp Eye Res 50: 119-126.
• Barrie KP, Gum GG, Samuelson DA, Gelatt KN (1985) Quantitation of uveoscleral outflow in normotensive and glaucomatous Beagles by 3H-labeled dextran. Am J Vet Res 46: 84-88.
• Bartels SP, Liu JH, Neufeld AH (1983) Decreased beta-adrenergic responsiveness in cornea and iris-ciliary body following topical timolol or epinephrine in albino and pigmented rabbits. Invest Ophthalmol Vis Sci 24: 718-724.
• Becker B, Morton WR (1966) Topical epinephrine in glaucoma suspects. Am J Ophthalmol 62: 272-227.
• Bill A (1966) Formation and drainage of aqueous humour in cats. Exp Eye Res 5: 185-190.
• Bill A (1969) Early effects of epinephrine on aqueous humor dynamics in vervet monkeys (Cercopithecus ethiops). Exp Eye Res 8: 35-43.
• Brooks DE, Garcia GA, Dreyer EB, Zurakowski D, Franco-Bourland RE (1997) Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res 58: 864-867.
• Brubaker RF (1998) Clinical measurements of aqueous dynamics: implications for addressing glaucoma. In: Civan MM (ed) The eye’s aqueous humor: from secretion to glaucoma. Academic Press, San Diego, pp 256-257.
• Carrier M, Gum GG (1989) Effects of 4% pilocarpine gel on normotensive and glaucomatous canine eyes. Am J Vet Res 50: 239-244.
• Cashwell LF, Shield MB, Reed JW (1977) Adrenochrome pigmentation. Arch Ophthalmol 95: 514-515.
• Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I (2012) Definition of glaucoma: clinical and experimental concepts. Clin Experiment Ophthalmol 40: 341-349.
• Cepelík J, Dedina M, Hynie S (1998) The effects of adrenergic agonists on intraocular pressure and on adenylyl cyclase activity of ciliary processes in pigmented rabbits. Physiol Res 47: 53-60.
• Chiou CY, Trzeciakowski J, Gelatt KN (1980) Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug. Invest Ophthalmol Vis Sci 19: 1198-1203.
• Coakes RL, Siah PB (1984) Effects of adrenergic drugs on aqueous humour dynamics in the normal human eye. I. Salbutamol. Br J Ophthalmol 68: 393-397.
• Crawford KS, Gange SJ, Gabelt BT, Heideman W, Robinson JC, Hubbard WC, Kaufman PL (1996) Indomethacin and epinephrine effects on outflow facility and cyclic adenosine monophosphate formation in monkeys. Invest Ophthalmol Vis Sci 37: 1348-1359.
• Erickson-Lamy KA, Nathanson JA (1992) Epinephrine increases facility of outflow and cyclic AMP content in the human eye in vitro. Invest Ophthalmol Vis Sci 33: 2672-2678.
• Erickson KA, Schroeder A (2000) Direct effects of muscarinic agents on the outflow pathways in human eyes. Invest Ophthalmol Vis Sci 41: 1743-1748.
• Flammer J, Orgul S (1998) Optic nerve blood-flow abnormalities in glaucoma. Prog Retin Eye Res 17: 267-289.
• Funk RH, Wagner W, Rohen JW (1992) The effect of epinephrine on ciliary process vasculature and IOP studied by intraocular microendoscopy in the albino rabbit. Curr Eye Res 11: 161-173.
• Gabelt BT, Seeman JL, Podos SM, Mittag TW, Kaufman PL (2004) Aqueous humor dynamics in monkeys after topical 8-iso PGE2. Invest Ophthalmol Vis Sci 45: 892-899.
• Garzia R (1982) An advance in ophthalmic pharmacology. The use of the epinephrine pro-drug dipivalyl epinephrine in the treatment of glaucoma. J Am Optom Assoc 53: 727-730.
• Gelatt KN, Brooks DE, Kallberg ME (2007) The canine glaucomas. In: Gelatt KN (ed) Veterinary Ophthalmology. Blackwell Publishing, Oxford, pp 753-811.
• Gelatt KN, Gum GG, Brooks DE, Wolf ED, Bromberg NM (1983) Dose response of topical pilocarpine-epinephrine combinations in normotensive and glaucomatous Beagles. Am J Vet Res 44: 2018-2027.
• Gelatt KN, Gum GG, Wolf ED, White MM (1984) Dose response of topical carbamylcholine chloride (carbachol) in normotensive and early glaucomatous beagles. Am J Vet Res 45: 547-554.
• Gharagozloo NZ, Larson RS, Kullerstrand W, Brubaker RF (1988) Terbutaline stimulates aqueous humor flow in humans during sleep. Arch Ophthalmol 106: 1218-1220.
• Goel M, Picciani RG, Lee RK, Bhattacharya SK (2010) Aqueous humor dynamics: a review. Open Ophthalmol J 4: 52-59.
• Grahn BH, Peiffer RL (2007) Fundamentals of veterinary ophthalmic pathology. In: Gelatt, KN (ed) Veterinary Ophthalmology. Blackwell Publishing, Oxford, p 402.
• Greller AL, Hoffman AR, Liu C, Ying GS, Vudathala DK, Acland GM, Komhromy AM (2008) Effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs. Am J Vet Res 69: 273-278.
• Gwin RM, Gelatt KN, Gum GG, Peiffer RL Jr (1978) Effects of topical 1-epinephrine and dipivalyl epinephrine on intraocular pressure and pupil size in the normotensive and glaucomatous Beagle. Am J Vet Res 39: 83-86.
• Gwin RM, Gelatt KN, Gum GG, Peiffer RL Jr, Williams LW (1977) The effect of topical pilocarpine on intraocular pressure and pupil size in the normotensive and glaucomatous beagle. Invest Ophthalmol Vis Sci 16: 1143-1148.
• Hung L, Yang CH, Chen MS (1995) Effect of pilocarpine on anterior chamber angles. J Ocul Pharmacol Ther 11: 221-226.
• Kaback MB, Podos SM, Harbin TS Jr, Mandell A, Becker B (1976) The effects of dipivalyl epinephrine on the eye. Am J Ophthalmol 81: 768-772.
• Kaiser PK, Pineda R, Albert DM, Shore JW (1992) „Black cornea” after long-term epinephrine use. Arch Ophthalmol 110: 1273-1275.
• Kaplan-Messas A, Naveh N, Avni I, Marshall J (2003) Ocular hypotensive effects of cholinergic and adrenergic drugs may be influenced by prostaglandins E2 in the human and rabbit eye. Eur J Ophthalmol 13: 18-23.
• Kobayashi H, Kobayashi K, Kiryu J, Kondo T (1999) Pilocarpine induces an increase in the anterior chamber angular width in eyes with narrow angles. Br J Ophthalmol 83: 553-558.
• Kohn AN, Moss AP, Hargett NA, Ritch R, Smith H Jr, Podos SM (1979) Clinical comparison of dipivalyl epinephrine and epinephrine in the treatment of glaucoma. Am J Ophthalmol 87: 196-201.
• Krieglstein GK, Leydhecker W (1978) The dose-response relationships of dipivalyl epinephrine in open-angle glaucoma. Albrecht von Graefes Arch Clin Exp Ophthalmol 205: 141-146.
• Krohne SG (1994) Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood- -aqueous barrier permeability in dogs. Am J Vet Res 55: 1729-1733.
• Krupin T, Feitl M, Becker B (1980) Effect of prazosin on aqueous humor dynamics in rabbits. Arch Ophthalmol 98: 1639-1642.
• Lee DA, Brubaker RF (1982) Effect of phenylephrine on aqueous humor flow. Curr Eye Res 2: 89-92.
• Lee DA, Brubaker RF, Nagataki S (1981) Effect of thymoxamine on aqueous humor formation in the normal human eye as measured by fluorophotometry. Invest Ophthalmol Vis Sci 21: 805-811.
• Mandell AI, Stentz F, Kitabchi AE (1978) Dipivalyl epinephrine: a new pro-drug in the treatment of glaucoma. Ophthalmology 85: 268-275.
• Martin CL (2010) Glaucoma. In: Martin CL (ed) Ophthalmic diseases in veterinary medicine. Manson Publishing Ltd, London, pp 337-364.
• McLellan GJ, Miller PE (2011) Feline glaucoma - a comprehensive review. Vet Ophthalmol 14 (Suppl 1): 15-29.
• Michelson G, Groh MJ (1994) Dipivefrin reduces blood flow in the ciliary body in humans. Ophthalmology 101: 659-664.
• Miller PE (2008) Glaucoma. In: Maggs DJ, Miller PE, Ofri R (eds) Slatter;s Fundamentals of Veterinary Ophthalmology. Saunders Elsevier, St Louis, pp 230-257.
• Miller PE, Schmidt GM, Vainisi SJ, Swanson JF, Herrmann MK (2000) The efficacy of topical prophylactic antiglaucoma therapy in primary closed angle glaucoma in dogs: a multicenter clinical trial. J Am Anim Hosp Assoc 36: 431-438.
• Nakamura M, Shirasawa E, Hikida M (1993) Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride. Ophthalmic Res 25: 46-51.
• Neufeld AH, Sears ML (1975) Adenosine 3’,5’-monophosphate analogue increases the outflow facility of the primate eye. Invest Ophthalmol 14: 688-689.
• Neufeld AH, Zawistowski KA, Page ED, Bromberg BB (1978) Influences on the density of beta-adrenergic receptors in the cornea and iris-ciliary body of the rabbit. Invest Ophthalmol Vis Sci 17: 1069-1075.
• Nilsson SF (1997) The uveoscleral outflow routes. Eye (Lond) 11: 149-154.
• Nilsson SF, Drecoll E, Lutjen-Drecoll E, Toris CB, Krauss AH, Kharlamb A, Nieves A, Guerra T, Woodward DF (2006) The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey. Invest Ophthalmol Vis Sci 47: 4042-4049.
• Pardos GJ, Krachmer JH, Mannis MJ (1980) Persistent corneal erosion secondary to tarsal adrenochrome deposit. Am J Ophthalmol 90: 870-871.
• Regnier A (2007) Antimicrobials, anti-inflammatory agents, and antiglaucoma drugs. In: Gelatt KN (ed) Veterinary Ophthalmology. Blackwell Publishing, Oxford, pp 228-331.
• Ritch R, Liebmann JM (1996) Argon laser peripheral iridoplasty. Ophthalmic Surg Lasers 27: 289-300.
• Ritch R, Lowe RF (1996) Angle-closure glaucoma: clinical types. In: Ritch R, Shields MB, Krupin T (eds) The glaucomas: clinical science. Mosbly-Year Book Inc, St Louis, pp 821-840.
• Robinson JC, Kaufman PL (1990) Effects and interactions of epinephrine, norepinephrine, timolol, and betaxolol on outflow facility in the cynomolgus monkey. Am J Ophthalmol 109: 189-194.
• Sarchahi AA, Abbasi N, Gholipour MA (2012) Effects of an unfixed combination of latanoprost and pilocarpine on the intraocular pressure and pupil size of normal dogs. Vet Ophthalmol 15 (Suppl 1): 64-70.
• Schenker HI, Yablonski ME, Podos SM, Linder L (1981) Fluorophotometric study of epinephrine and timolol in human subjects. Arch Ophthalmol 99: 1212-1216.
• Smith LN, Miller PE, Felchle LM (2010) Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs. Am J Vet Res 71: 1055-1061.
• Spaeth GL (1967) Nasolacrimal duct obstruction caused by topical epinephrine. Arch Ophthalmol 77: 355-357.
• Townsend DJ, Brubaker RF (1980) Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry. Invest Ophthalmol Vis Sci 19: 256-266.
• Wang YL, Toris CB, Zhan G, Yablonski ME (1999) Effects of topical epinephrine on aqueous humor dynamics in the cat. Exp Eye Res 68: 439-445.
• Wei CP, Anderson JA, Leopold I (1978) Ocular absorption and metabolism of topically applied epinephrine and a dipivalyl ester of epinephrine. Invest Ophthalmol Vis Sci 17: 315-321.
• Whitley RD, Gelatt KN, Gum GG (1980) Dose-response of topical pilocarpine in the normotensive and glaucomatous Beagle. Am J Vet Res 41: 417-424.
• Wilkie DA, Latimer CA (1991) Effects of topical administration of 2.0% pilocarpine on intraocular pressure and pupil size in cats. Am J Vet Res 52: 441-444.

Identyfikatory

DOI

10.2478/pjvs-2014-0110