Pharmacological and therapeutic application of Asparagus racemosus Willd.

• Autorzy: Tuszynska M.

Warianty tytułu

PL

Zastosowanie farmakologiczne i terapeutyczne Asparagus racemosus Willd

• Języki publikacji: EN

Abstrakty

EN

Phenolic compounds form one of the main classes of secondary metabolites. They display a large range of structures and are responsible for the major organoleptic characteristics of plant-derived foods and beverages, particularly color and taste properties. They also contribute to the nutritional qualities of fruits and vegetables. Among these compounds, flavonoids constitute one of the most prevailing groups among plant phenolics. Owing to their importance in food organoleptic properties and human health, a better understanding of their structures and biological activities indicates their potentials as therapeutic agents and also for predicting and controlling food quality. Due to the variety of pharmacological activities in the mammalian body, flavonoids are more correctly referred as “nutraceuticals”.

PL

Związki fenolowe są jedną z głównych grup metabolitów wtórnych. Mogą mieć bardzo różną strukturę i są odpowiedzialne za większość cech organoleptycznych żywności pochodzenia roślinnego i napojów, szczególnie za ich właściwości kolorystyczne i smakowe. Podwyższają także wartości odżywcze owoców i warzyw. Flawonoidy są jedną z największych grup fenoli roślinnych. Lepsze zrozumienie budowy i właściwości biologicznych tych związków może wykazać ich potencjał jako związków leczniczych, a także mających znaczenie w jakości żywności. Ze względu na różnorodność działań farmakologicznych w organizmach ssaków, flawonoidy powinno się nazywać „nutraceutykami”.

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2010
• Tom: 56
• Numer: 2
• Opis fizyczny: p.92-104,fig.,ref.

Twórcy

autor

Tuszynska M.

• Department of Vegetable Storage and Processing, Research Institute of Vegetable Crops, Konstytucji 3 Maja 1/3, 96-100 Skierniewice, Poland

Bibliografia

• 1. De Groot H, Raven U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharma Col 1998; 12:249-55.
• 2. R obak J, Gryglewski RJ. Bioactivity of flavonoids. Pol J Pharmacol 1996; 48:555-64.
• 3. R anaud S, de Lorgeril M. Wine, alcohol, platelets, and the french paradox for coronary heart disease. Lancet 1992; 339(8808):1523-6.
• 4. H arborne JB. The flavonoids – Advances in Research since 1980. Ed 1. London 1988.
• 5. Middleton E. The flavonoids. Trends Pharmacol Sci 1984; 5:335-8.
• 6. H avsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 1983; 32(7):1141-8.
• 7. H arborne JB. Nature, distribution and function of plant flavonoids. In: Cody V, Middleton Elliott Jr, Harborne JB (eds.). Plant flavonoids in biology and medicine: biochemical, pharmacological and structure activity relationship. New York 1986:15-24.
• 8. H arborne JB, Baxter, H. The handbook of natural flavonoids. Vol.1-2. New York 1999.
• 9. DeFelice SL. Nutraceuticals: Opportunities in an Emerging Market. Scrip Mag 1992; 9:xxx-yyy. 115
• 10. Dillard, CJ, German JB. Phytochemicals: nutraceuticals and human health. J Sci Food Agric 2000; 80:1744-56.
• 11. De Groot H. Reactive oxygen species in tissue injury. Hepatogastroenterology 1994; 41:328-32.
• 12. Grace PA. Ischaemia-reperfusion injury. Br J Surg 1994; 81:637-47.
• 13. Wegener T, Fintelmann V. Flavonoids and bioactivity. Wein Med Wochem Schr 1999; 149:241-7. 14. Ares JJ, Outt PE. Gastroprotective agents for the prevention of NSAID induced gastropathy. Curr Pharm
• Des 1998; 4:7-36. 15. H illwell B. Free radicals, antioxidants and human disease: Curiosity, cause or constipation. Lancet 1994; 344:721-4.
• 16. Fraga CG, Mactino US, Ferraro GE, Coussio JF, Boveris A. Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence. Biochem Med Metabol Biol 1987; 36:717-20.
• 17. R atty AK. Effects of flavonoids on nonenzymatic lipid peroxidation: structure activity relationship. Biochem Med Metabol Biol 1988; 39:67-79.
• 18. B ors W, Heller W, Michel C, Saran M. Flavonoids as antioxidant: Determination of radical scavenging efficiencies. Methods Ezymol, 1990; 186:343-355.
• 19. Cotelle N, Bernier JL, Catteau JP, Pommery J, Wallet JC, Gaydou EM. Antioxidant activity of hydroxy flavonoids. Free Radic Biol Med 1996; 20:35-43.
• 20. R ice-Evans CA, Nicholas JM, Paganga G. Structure antioxidant activity relationships of flavonoids and phenolic acid. Free Radic Biol Med 1996; 20(7):933-56.
• 21. Amic D, Davidovic-Amic D, Beslo D, Trinajstic N. Structure radical scavenging activity relationships of flavonoids. Croat Chem Act 2003; 76:55-61.
• 22. Farkas O, Jakus J, Heberger K. Quantitative structure-antioxidant activity relationship of flavonoid compounds. Molecules 2004; 9:1079-88.
• 23. H avsteen B. Flavonoids: A class of natural products of high pharmacological potency. Biochem Pharmacol 1983; 32(7):1141-8.
• 24. Tencate JW, van Hoeringen NJ, Gerritsen J, Glasius E. Biological activity of a semisynthetic flavonoid O-(hydroxyethyl) rutosine: Light scattering and metabolic studies of human red cells and platelets. Clin Chem 1973; 19:31-5.
• 25. Selway JWT. Antiviral activity of flavones and flavans. In: Cody V, Middleton E, Harborne JB (eds.). Plant flavonoids in biology and medicine: Biochemical, pharmacological and structure activity relationships. New York 1986; 521-36.
• 26. Thomas PRS, Nash GB, Dormandly JA. White cells accumulation in dependent legs of patients with venous hypertension: A possible mechanism for trophic changes in the skin. Br Med J 1988; 296:1673-95.
• 27. Loewenstein WR. Junctional Intercellular communication and the control of growth. Biochem Biophys Acta 1979; 560:1-65.
• 28. Ng TB, Huang B, Fong WP, Yeung HW. Anti-human immunodeficiency virus (anti-HI V) natural products with special emphasis on HI V transcriptase inhibitors. Life Sci 1997; 61:933-49.
• 29. Gerdin B, Srensso E. Inhibitory effect of flavonoids on increased microvascular permeability induced by various agents in rat skin. Int J Micro Cir Clin Exp 1983; 2:39-46.
• 30. Alarcon DL, Martin MJ, Locasa C, Motilva V. Antiulcerogenic activity of flavonoids and gastric protection. Ethnopharmacol 1994; 42:161-70.
• 31. I zzo AA, Carlo GD, Mascolo N, Capasso F, Autore G. Effect of quercetin on gastrointestinal tract. Phyto Ther Res 1994; 8:179-85.
• 32. Carlo GD, Autore G, Izzoaa et al. Inhibition of intestinal motility and secretion by flavonoids in mice and rats; structure activity relationships. J Pharm Pharmcol 1993; 45:1045-59.
• 33. Lorenz W, Kusche J, Barth H, Mathias CH. Action of several flavonoids on enzyme of histidine metabolism in vivo. In: Cz. Maslinski (ed.). Histamine. Pennsylvania 1994; 265-9.
• 34. Lee SJ, Son KH, Chang HW et al. Anti-inflammatory activity of naturally occurring flavone and flavonol glycosides. Arch Pharm Res 1993; 16(1):25-8.
• 35. H ang T, Jin JB, Cho S, Cyang JC. Evaluation of anti-inflammatory effects of baicalein on dextran sulfate sodium-induced colitis in mice. Planta Med 2002; 68(2):268-71.
• 36. Shahid F, Yang Z, Saleemi ZO. Natural flavonoids as stabilizers. J Food Lipids 1998; volume:69-75.
• 37. Farmica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Fd Chem Toxic 1995; 33(12):1061-80.
• 38. Ferrandiz ML, Alcaraz MJ. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by lavonoids. Agent and Actions 1991; 32(3/4):283-8.
• 39. Kim HP, Mani I, Iversen L, Ziboh VA. Effects of naturally occurring flavonoids and bioflavonoids on epidermal cycloxygenase and lipoxygenase from guinea pigs. Prostag Leukot Essent Fatty Acids 1998; 58:17-24.
• 40. Jachak SM. Natural products: Potential source of COX inhibitors. CRI PS 2001; 2(1):12-15.
• 41. Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin induced diabetic rats. Comp Biochem Physiol 2003; 135:357-64.
• 42. H if CS, Howell SL. Effects of epicatechin on rat islets of langerhans. Diabetes, 1984; 33:291-296.
• 43. H if CS, Howell SL. Effects of flavonoids on insulin secretion and 45Ca+2 handling in rat islets of langerhans. J Endocrinol 1985; 107:1-8.
• 44. I ijima K, Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol 2001; 12:41-48.
• 45. B ernatova I, Pechanova O, Balal P et al. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Cir Physiol 2002; 282:942-8.
• 46. Jayakody TL, Senaratne MPJ, Thompson ABR , Kappagoda CT. Cholesterol feeding impairs endotheliumdependent relaxation of rabbit aorta. Can J Physiol Pharmacol 1985; 63:1206-9.
• 47. H ertag MG, Feskens EJ, Hallman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the zutphen elderly study. Lancet 1993; 342:1007-11.
• 48. H ertog MG, Hallman PC, Katan MB, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 1993; 20:21-9.
• 49. Andriambeloson E, Kleschyov Al, Muller B et al. Nitric oxide production and endothelium dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 1997;120:1053-8.
• 50. B urns J, Gardner PT, O’Neil J et al. Relationship among antioxidant activity, vasodilation capacity and phenolic content of red wines. J Agric Food Chem 2000; 48:220-30.
• 51. De-Whallely C, Rankin SM, Houct JRS et al. Flavonoids inhibit the oxidative modification of low density lipoprotein by macrophages. Biochem Pharmacol 1990; 39:1743-50.
• 52. Fuhrman B, Lavy A, Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoproteins to lipid peroxidation. Am Soc Nutr 1995; 61:549-54.
• 53. Arai Y, Watanabe S, Kimira M et al. Dietary intake of flavonols, flavones and isoflavones by Japanesee women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000; 130:2243-50.
• 54. Lou FQ, Zhang MF, Zhang XG, Liu JM, Yuan WL. A study on tea pigment in prevention of antherosclerosis. Chin Med J (Engl) 1989; 102:579-83.
• 55. Osman HE , Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits plate activity in dogs and monkey’s. J Nutr 1998; 128:2307-12.
• 56. Gryglewski RJ, Korbut R, Robak J, Swips J. On the mechanism of anti thrombotic action of flavonoids. Biochem Pharmacol 1987; 36:317-22.
• 57. Alcaraz MJ, Ferrandiz ML. Modification of arachidonic metabolism by flavonoids. J Ethnopharmacol 1987; 21:209-29.
• 58. Kandaswami C, Middleton E. Free radical scavenging and antioxidant activity of plant flavonoids. In: Armstrong D ed. Free radicals in diagnostic medicine, New York: Plenum Press, Ed 2, 1994. 351-376.
• 59. Lackeman GM, Claeys M, Rwanagabo PC, Herman AG, Vlietinck A. Chronotropic effect of quercetin on guinea pig right atrium. J Planta Med 1986; 52:433-9.
• 60. H uesken BCP, Dejong J, Beekman B, Onderwater RCA. Flavonoids as cardioprotective agents. Cancer Chemotheapy Pharmacol 1995; 37:55-62.
• 61. B ast A, Kaiserov H, den Hartog GJM, Haenen GRMM, van der Vijgh WJF. Protectors against doxorubicininducedcardiotoxicity: Flavonoids. Cell Biol Toxicol 2007; 23:39-47.
• 62. Kontruck SJ, Radecki T, Brozozowski T et al. Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophorandin. Role of endogenous prostaglandins. Bur J Pharmac 1986; 125:185-92.
• 63. I zzo AA, Dicarlo, G, mascolo N, Capasso F, Autore G. Antiulcer effects of flavonoids. Role of endogenous PAF. Phytotherapy Res 1991; 8:179-81.
• 64. Murakami S, Muramatsu M, Otomo S. Gastric H+/K+ ATPase inhibition by catechins. J Pharm Pharmacol 1992; 44:926-8.
• 65. Kim HK, Namgoong SY, Kim HP. Biological actions of flavonoids-I. Arch Pharmacol Res 1993; 16:18-27.
• 66. Gill B, Sanz MJ, Terencio MC, Ferrandiz ML, Bustos G, Paya M. The flavonoids. Life Sci 1994; 54:333-9.
• 67. H irano T, Gotoh M, Oak K. Natural flavonoids and lignans are plant cytostatic agents against Human Leukemic HL-60 cells. Life Sci 1994; 55:1061-9.
• 68. Wei H, Tye L, Bresnick E, Birt DF. Inhibitory effect of Apigenin, a plant flavonoids on epidermal ornithine decarboxylase skin tumor promotion in mice. Cancer Res 1990; 50: 499-502.
• 69. Griebel G, Perrault G, Tan S, Schoemarker H, Sanger DJ. Pharmacological studies on synthetic flavonoids: Comparison with diazepam. Neuropharmacol 1999; 38:965-77.
• 70. Starvic B. Mutagenic food flavonoids. Fed Proc 1984; 43:2344.
• 71. Dunnick JK, Hailey JR. Toxicity and carcinogenicity studies of quercetin, a natural component of food. Fundam Appl Toxicol 1992; 19:423-31.
• 72. Plakas SM, Lee TC, Wolke RE . Absence of overt toxicity from feeding the flavonol, quercetin trainbow trout (Calmo gairdneri). Food Chem Toxicol 1985; 23:1077-80.

Uwagi

rekord w opracowaniu