Frequency specific changes in signal power and functional conectivity following stroke in the cat visual cortex

• Autorzy: Paulina Urban1, Andrzej Foik1, Anaida Ghazaryan1, Anna Popek1, Jan Jabłonka3, Ewa Kublik2, Maciek Kamiński4, Rafał Kuś4, Jarosław Żygierewicz4, Wioletta Waleszczyk1 P. , Folk A. , Ghazanyan A. , Popek A. , Jablonka J. , Kublik E. , Kaminski M. , Kus R. , Zygierewicz J. , Waleszczyk W.
• Języki publikacji: EN

Abstrakty

EN

AIM: The aim of the study wasto characterize early reorganization of cortical electrical activity within and around the stroke-affected area. METHODS: Photothrombotic stroke wasinduced in the visual cortex during the acute experiments in anaesthetized cats. The activity of neuronal populations (local field potential, LFP) were continuously monitored in the central region of the stroke, at the stroke border, and in the healthy tissue, up to three hours after stroke. In the offline analysis, using Welch and autoregressive parametric methods, we evaluated the changes in the frequency spectrum spanning from delta to gamma. Functional connectivity between cortical locations within and outside the stroke region was determined with Directed Transfer Function (DTF). Indirect and direct interactions in different frequency bands were determined by DTF and direct DTF, respectively. RESULTS: The stroke resulted in an overall decrease of the power within full frequency spectrum in the stroke affected region, but not outside this region, where an increase in the spectral power was observed. The most pronounced changes were observed three hours after the stroke. In one cat, we observed increase of the power in the stroke area in low frequency bands while the power in beta-gamma band was diminished. DTF and direct DTF revealed weakening of neuronal connections between the healthy tissue and the stroke region and a transient strengthening of local connections outside the stroke region. The earliest decrease in the strength of connections in stroke affected region was observed in high frequencies (beta and gamma). CONCLUSION: Stroke induce diverse effects in different frequency bands in both the LFP power spectrum and in the functional connectivity indicating complex influence on the neuronal activity within the stroke and in the vicinity of ischemic region. Supported by ERA-NET Neuron project REVIS.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S98

Twórcy

autor

Paulina Urban1, Andrzej Foik1, Anaida Ghazaryan1, Anna Popek1, Jan Jabłonka3, Ewa Kublik2, Maciek Kamiński4, Rafał Kuś4, Jarosław Żygierewicz4, Wioletta Waleszczyk1 P.

• Neurobiology of Vision Laboratory, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Folk A.

• Neurobiology of Vision Laboratory, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Ghazanyan A.

• Neurobiology of Vision Laboratory, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Popek A.

• Neurobiology of Vision Laboratory, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Jablonka J.

• Laboratory of Animal Physiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

autor

Kublik E.

• Laboratory of Visual System, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Kaminski M.

• Laboratory of Medical Physics, Institute of Experimental Physics, University of Warsaw, Warsaw, Poland

autor

Kus R.

• Laboratory of Medical Physics, Institute of Experimental Physics, University of Warsaw, Warsaw, Poland

autor

Zygierewicz J.

• Laboratory of Medical Physics, Institute of Experimental Physics, University of Warsaw, Warsaw, Poland

autor

Waleszczyk W.

• Neurobiology of Vision Laboratory, Department of Neuropgysiology, Nencki Institute of Experimetal Biology, Polish Academy of Sciences, Warsaw, Poland