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2013 | 60 | 2 |

Tytuł artykułu

The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
 Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).

Wydawca

-

Rocznik

Tom

60

Numer

2

Opis fizyczny

p.259-262,fig.,ref.

Twórcy

  • Chair of Medicinal Chemistry, Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
autor
  • Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
autor
  • Department of Cardiovascular Physiology, Medical University of Lodz, Lodz, Poland
autor
  • Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
  • Chair of Medicinal Chemistry, Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
  • Department of Cardiovascular Physiology, Medical University of Lodz, Lodz, Poland

Bibliografia

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Typ dokumentu

Bibliografia

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