Regulation of lncRNA expression

• Autorzy: Wu Z. , Liu X. , Liu L. , Deng H. , Zhang J. , Xu Q. , Cen B. , Ji A.
• Języki publikacji: EN

Abstrakty

EN

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

Słowa kluczowe

EN

post-transcriptional regulation; incRNA; dynamic expression; biological function; chromatin; transcription factor; DNA sequence; microRNA

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2014
• Tom: 19
• Numer: 4
• Opis fizyczny: p.561-575,fig.,ref.

Twórcy

autor

Wu Z.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Liu X.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Liu L.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Deng H.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Zhang J.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Xu Q.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Cen B.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

autor

Ji A.

• Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China

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Identyfikatory

DOI

10.2478/s11658-014-0212-6