Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats

• Autorzy: Phanindhra B. , Raju A.B. , Vikas G. , Anusha R. , Deepika D.

Warianty tytułu

PL

Wpływ wyciągu z liści Nyctanthes arbor tristis na zaburzenia poznawcze indukowane skopolaminą u szczurów

• Języki publikacji: EN

Abstrakty

EN

Nyctanthes arbor tristis (NATE) ethanol extract (150 mg/kg, orally) was evaluated for its protective effect against scopolamine-induced (1 mg/kg i.p.) cognitive impairments in rats using behavioral models like radial arm maze test, Morris water maze test and active avoidance test. NATE effect was evaluated and compared with the standard piracetam (200mg/kg i.p.). NATE (p<0.005) significantly reversed the impairment produced by the scopolamine in radial arm maze test. In addition, NATE also decreased the time period taken to find the hidden platform in Morris water maze test and increased number of avoidances in active avoidance paradigm. Acetylcholinesterase activity and thiobarbituric acid levels were significantly (p<0.005) decreased along with the rise in activities of superoxide dismutase and catalase. This might suggest that the NATE has protective effect against scopolamine-induced cognitive impairment in rats through acetylcholine muscarinic receptor pathway and also antioxidant activity. No significant changes were found in histopathological studies of brain.

PL

Badano działanie protekcyjne wyciągu etanolowego z Nyctanthes arbor tristis (NATE) (150 mg/kg, podawany dożołądkowo) skierowane przeciwko zaburzeniom poznawczym wywołanym stosowaniem skopolaminy (1 mg/kg i.p.) u szczurów, stosując odpowiednie modele behawioralne takie jak: test labiryntu ramion promienistych (radial arm maze test), test labiryntu wodnego Morrisa i test aktywnego unikania. Wynik NATE został porównany z działaniem piracetamu (200 mg/kg i.p.). W teście labiryntu ramion promienistych NATE (p<0.005) istotnie hamował zaburzenia wywołane podaniem skopolaminy. Dodatkowo NATE także skrócił czas potrzebny do wykonania zadań w teście Morrisa i zwiększył sprawność wykonywania zadań w teście aktywnego unikania. Aktywność acetylcholinesterazy i stężenia kwasu tiobarbiturowego zmniejszyły się istotnie (p<0.005) równolegle ze zwiększeniem działania dysmutazy ponadtlenkowej i katalazy. To może sugerować, że NATE ma wykazywać efekt ochronny przeciwko zaburzeniom procesów poznawczych u szczurów wywołanym przez skopolaminę zarówno poprzez receptory muskarynowe, jak i poprzez działanie antyoksydacyjne. Badanie histopatologiczne mózgowia zwierząt nie wykazało istotnych zmian.

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2014
• Tom: 60
• Numer: 4
• Opis fizyczny: p.34-49,fig.,ref.

Twórcy

autor

Phanindhra B.

• Department of Pharmacology, St.Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, India

autor

Raju A.B.

• Department of Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia

autor

Vikas G.

• Department of Pharmacology, St.Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, India

autor

Anusha R.

• Department of Pharmacology, St.Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, India

autor

Deepika D.

• Department of Pharmacology, St.Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, India

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Identyfikatory

DOI

10.1515/hepo-2015-0003