Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 70 | 05 |
Tytuł artykułu

Podkliniczna i kliniczna cirkowiroza świń - zmienność wirusa PCV2

Warianty tytułu
Subclinical and clinical circoviral infection of swine - variability of PCV2
Języki publikacji
The paper is presenting basic data about circoviruses of swine and subclinical infection or disease they alternatively may cause. PCV1 is mentioned as being non pathogenic. Much more in detail is characterized the PCV2, being at present evaluated as one of the most important pathogenic viruses of swine. The virus is subdivided into genotypes of which PCV2a and PCV2b are the most pathogenic variants. The interaction between PCV2 and its natural hosts, domestic pig and wild boar, is a complex process. Two forms are differentiated: PCV2 – subclinical infection (PCV2-SI) and a disease with clinical symptoms, named nowadays PCV2 – systemic disease (PCV2-SD), replacing the earlier name: postweaning, multisystemic wasting syndrome (PMWS). However there is at present no satisfactory explanation why at the end of the 1990s or beginning of the XXI. century PCV2-SD from a mild and sporadic one changed into a severe epidemic disease. It is at present speculated that some role, contributing to this change may be played by the growing international trade of pigs belonging to susceptible swine genetic lines. The role of vaccination, contributing to selection of pathogenic variants of PCV2 could also be taken into account. An other factor could be co-infections, particularly with PRRSV, PPV and Mycoplasma hyopneumoniae. To some extend changes in management and husbandry could not be excluded. Nevertheless it is necessary to continue research in order to improve knowledge in this area.
Opis fizyczny
  • Zakład Chorób Świń, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy, Al.Partyzantów 57, 24-100 Puławy
  • Zakład Chorób Świń, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy, Al.Partyzantów 57, 24-100 Puławy
  • 1. Allan G., Krakowka S., Ellis J., Charreyre C.: Discovery and evolving history of two genetically related but phenotypically different viruses, porcine circoviruses 1 and 2. Virus Res. 2012, 164, 4-9.
  • 2. Allan G. M., Ellis J. A.: Porcine circoviruses: a review. J. Vet. Diagn. Invest. 2000, 12, 3-14.
  • 3. Allan G. M., McNeilly F., Ellis J., Krakowka S., Botner A., McCullough K., Nauwynck H., Kennedy S., Meehan B., Charreyre C.: PMWS: experimental model and co-infections. Vet. Microbiol. 2004, 98, 165-168.
  • 4. Andraud M., Rose N., Grasland B., Pierre J. S., Jestin A., Madec F.: Influence of husbandry and control measures on porcine circovirus type 2 (PCV-2) dynamics within a farrow-to-finish pig farm: a modelling approach. Prev. Vet. Med. 2009, 92, 38-51.
  • 5. Calsamiglia M., Fraile L., Espinal A., Cuxart A., Seminati C., Martín M., Mateu E., Domingo M., Segalés J.: Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS). Res. Vet. Sci. 2007, 82, 299-304.
  • 6. Carman S., McEwen B., DeLay J., van Dreumel T., Lusis P., Cai H., Fairles J.: Porcine circovirus-2 associated disease in swine in Ontario (2004 to 2005). Can. Vet. J. 2006, 47, 761-762.
  • 7. Cheung A. K., Lager K. M., Kohutyuk O. I., Vincent A. L., Henry S. C., Baker R. B., Rowland R. R., Dunham A. G.: Detection of two porcine circovirus type 2 genotypic groups in United States swine herds. Arch. Virol. 2007, 152, 1035-1044.
  • 8. Chiarelli-Neto O., Yotoko K. S., Vidigal P. M., Silva F. M., Castro L. A., Fietto J. L., Silva Jr., A., Almeida M. R.: Classification and putative origins of Brazilian porcine circovirus 2 inferred through phylogenetic and phylogeographical approaches. Virus Res. 2009, 140, 57-63.
  • 9. Choi C., Chae C., Clark E. G.: Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction. J. Vet. Diagn. Invest. 2000, 12, 151-153.
  • 10. Clark E. G.: Post-weaning multisystemic wasting syndrome. Proc. West Can. Assoc. Swine Pract. 1996, 19-20.
  • 11. Cortey M., Olvera A., Grau-Roma L., Segalés J.: Further comments on porcine circovirus type 2 (PCV2) genotype definition and nomenclature. Vet. Microbiol. 2011, 149, 522–523.
  • 12. Cortey M., Pileri E., Sibila M., Pujols J., Balasch M., Plana J., Segalés J.: Genotypic shift of porcine circovirus type 2 from PCV-2a to PCV-2b in Spain from 1985 to 2008. Vet. J. 2011, 187, 363-368.
  • 13. Dupont K., Nielsen E. O., Baekbo P., Larsen L. E.: Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time. Vet. Microbiol. 2008, 128, 56-64.
  • 14. Firth C., Charleston M. A., Duffy S., Shapiro B., Holmes E. C.: Insights into the evolutionary history of an emerging livestock pathogen: porcine circovirus 2. J. Virol. 2009, 83, 12813-12821.
  • 15. Fort M., Olvera A., Sibila M., Segalés J., Mateu E.: Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs. Vet. Microbiol. 2007, 125, 244-255.
  • 16. Gagnon C. A., Tremblay D., Tijssen P., Venne M. H., Houde A., Elahi S. M.: The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada. Can. Vet. J. 2007, 48, 811-819.
  • 17. Grau-Roma L., Crisci E., Sibila M., López-Soria S., Nofrarias M., Cortey M., Fraile L., Olvera A., Segalés J.: A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence. Vet. Microbiol. 2008, 128, 23-35.
  • 18. Grau-Roma L., Fraile L., Segalés J.: Recent advances in the epidemiology, diagnosis and control of diseases caused by porcine circovirus type 2. Vet. J. 2011, 187, 23-32.
  • 19. Grau-Roma L., Hjulsager C. K., Sibila M., Kristensen C. S., López-Soria S., Enoe C., Casal J., Botner A., Nofrarias M., Bille-Hansen V., Fraile L., Baekbo P., Segalés J., Larsen L. E.: Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark. Vet. Microbiol. 2009, 135, 272-282.
  • 20. Grau-Roma L., Stockmarr A., Kristensen C. S., Enoe C., López-Soria S., Nofrarías M., Bille-Hansen V., Hjulsager C. K., Sibila M., Jorsal S. E., Fraile L., Baekbo P., Vigre H., Segalés J., Larsen L. E.: Infectious risk factors for individual postweaning multisystemic wasting syndrome (PMWS) development in pigs from affected farms in Spain and Denmark. Res. Vet. Sci. 2012, 93, 1231-1240.
  • 21. Hamberg A., Ringler S., Krakowka S.: A novel method for the detection of porcine circovirus type 2 replicative double stranded viral DNA and nonreplicative single stranded viral DNA in tissue sections. J. Vet. Diagn. Invest. 2007, 19, 135-141.
  • 22. Harding J. C.: Postweaning multisystemic wasting syndrome: preliminary epidemiology and clinical findings. Proc. West Can. Assoc. Swine Pract. 1996, 21.
  • 23. Jacobsen B., Krueger L., Seeliger F., Bruegmann M., Segalés J., Baumgaertner W.: Retrospective study on the occurrence of porcine circovirus 2 infection and associated entities in Northern Germany. Vet. Microbiol. 2009, 138, 27-33.
  • 24. Kekarainen T., McCullough K., Fort M., Fossum C., Segalés J., Allan G. M.: Immune responses and vaccine-induced immunity against Porcine circovirus type 2. Vet. Immunol. Immunopathol. 2010, 136, 185-193.
  • 25. Krakowka S., Ellis J. A., McNeilly F., Ringler S., Rings D. M., Allan G.: Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet. Pathol. 2001, 38, 31-42.
  • 26. LeCann P., Albina E., Madec F., Cariolet R., Jestin A.: Piglet wasting disease. Vet. Rec. 1997, 141, 660.
  • 27. López-Soria S., Segalés J., Rose N., Vinas M. J., Blanchard P., Madec F., Jestin A., Casal J., Domingo M.: An exploratory study on risk factors for postweaning multisystemic wasting syndrome (PMWS) in Spain. Prev. Vet. Med. 2005, 69, 97-107.
  • 28. Mankertz A., Domingo M., Folch J. M., LeCann P., Jestin A., Segalés J., Chmielewicz B., Plana-Duran J., Soike D.: Characterisation of PCV-2 isolates from Spain, Germany and France. Virus Res. 2000, 66, 65-77.
  • 29. McKeown N. E., Opriessnig T., Thomas P., Guenette D. K., Elvinger F., Fenaux M., Halbur P.G., Meng X. J.: Effects of porcine circovirus type 2 (PCV2) maternal antibodies on experimental infection of piglets with PCV2. Clin. Diagn. Lab. Immunol. 2005, 12, 1347-1351.
  • 30. Nauwynck H. J., Sanchez R., Meerts P., Lefebvre D. J., Saha D., Huang L., Misinzo G.: Cell tropism and entry of porcine circovirus 2. Virus Res. 2012, 164, 43-45.
  • 31. Olvera A., Cortey M., Segalés J.: Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality. Virology 2007, 357, 175-185.
  • 32. Opriessnig T., Fenaux M., Thomas P., Hoogland M. J., Rothschild M. F., Meng X. J., Halbur P. G.: Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions. Vet. Pathol. 2006, 43, 281-293.
  • 33. Opriessnig T., Patterson A. R., Madson D. M., Pal N., Rothschild M., Kuhar D., Lunney J. K., Juhan N. M., Meng X. J., Halbur P. G.: Difference in severity of porcine circovirus type two-induced pathological lesions between Landrace and Pietrain pigs. J. Anim. Sci. 2009, 87, 1582-1590.
  • 34. Opriessnig T., Ramamoorthy S., Madson D. M., Patterson A. R., Pal N., Carman S., Meng X. J., Halbur P. G.: Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. J. Gen. Virol. 2008, 89, 2482-2491.
  • 35. Patterson A. R., Opriessnig T.: Epidemiology and horizontal transmission of porcine circovirus type 2 (PCV2). Anim. Health Res. Rev. 2010, 11, 217-234.
  • 36. Pejsak Z., Dors A.: Sytuacja w produkcji świń w Europie centralnej, w tym w Polsce – źródła kryzysu. Magazyn Wet. Choroby Świń – Monografia 2013, 6, 486-491.
  • 37. Pérez L. J., de Arce H. D., Cortey M., Dominguez P., Percedo M. I., Perera C. L., Tarradas J., Frias M. T., Segalés J., Ganges L., Nunez J. I.: Phylogenetic networks to study the origin and evolution of porcine circovirus type 2 (PCV2) in Cuba. Vet. Microbiol. 2011, 151, 245-254.
  • 38. Pérez-Martín E., Rovira A., Calsamiglia M., Mankertz A., Rodríguez F., Segalés J.: A new method to identify cell types that support porcine circovirus type 2 replication in formalin-fixed, paraffin-embedded swine tissues. J. Virol. Methods 2007, 146, 86-95.
  • 39. Rodríguez-Arrioja G. M., Segalés J., Calsamiglia M., Resendes A. R., Balasch M., Plana-Duran J., Casal J., Domingo M.: Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome. Am. J. Vet. Res. 2002, 63, 354-357.
  • 40. Rose N., Eveno E., Grasland B., Nignol A. C., Oger A., Jestin A., Madec F.: Individual risk factors for Post-weaning Multisystemic Wasting Syndrome (PMWS) in pigs: a hierarchical Bayesian survival analysis. Prev. Vet. Med. 2009, 90, 168-179.
  • 41. Rose N., Larour G., Le Diguerher G., Eveno E., Jolly J. P., Blanchard P., Oger A., Le Dimna M., Jestin A., Madec F.: Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French farrow-to-finish herds. Prev. Vet. Med. 2003, 61, 209-225.
  • 42. Rose N., Opriessnig T., Grasland B., Jestin A.: Epidemiology and transmission of porcine circovirus type 2 (PCV2). Virus Res. 2012, 164, 78-89.
  • 43. Sato K., Shibahara T., Ishikawa Y., Kondo H., Kubo M., Kadota K.: Evidence of porcine circovirus infection in pigs with wasting disease syndrome from 1985 to 1999 in Hokkaido, Japan. J. Vet. Med. Sci. 2000, 62, 627-633.
  • 44. Segalés J., Allan G. M., Domingo M.: Porcine circoviruses, [w:] Zimmerman J., Karriker L., Ramírez A., Shwartz K., Stevenson G. (Eds.): Diseases of Swine. 10th Edition. Wiley-Blackwell 2012, 405-1417.
  • 45. Segalés J., Domingo M.: Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Vet. Q. 2002, 24, 109-124.
  • 46. Segalés J., Kekarainen T., Cortey M.: The natural history of porcine circovirus type 2: From an inoffensive virus to a devastating swine disease? Vet. Microbiol. 2013, 165, 13-20.
  • 47. Segalés J., Olvera A., Grau-Roma L., Charreyre C., Nauwynck H., Larsen L., Dupont K., McCullough K., Ellis J., Krakowka S., Mankertz A., Fredholm M., Fossum C., Timmusk S., Stockhofe-Zurwieden N., Beattie V., Armstrong D., Grassland B., Baekbo P., Allan G.: PCV-2 genotype definition and nomenclature. Vet. Rec. 2008, 162, 867-868.
  • 48. Segalés J., Sitjar M., Domingo M., Dee S., Del Pozo M., Noval R., Sacristan C., De las Heras A., Ferro A., Latimer K. S.: First report of post-weaning multisystemic wasting syndrome in pigs in Spain. Vet. Rec. 1997, 141, 600-601.
  • 49. Timmusk S., Wallgren P., Brunborg I. M., Wikstrom F. H., Allan G., Meehan B., McMenamy M., McNeilly F., Fuxler L., Belak K., Podersoo D., Saar T., Berg M., Fossum C.: Phylogenetic analysis of porcine circovirus type 2 (PCV2) pre- and post-epizootic postweaning multisystemic wasting syndrome (PMWS). Virus Genes 2008, 36, 509-520.
  • 50. Tischer I., Gelderblom H., Vettermann W., Koch M. A.: A very small porcine virus with circular single-stranded DNA. Nature 1982, 295, 64-66.
  • 51. Tischer I., Rasch R., Tochtermann G.: Characterization of papovavirus- and picornavirus-like particles in permanent pig kidney cell lines. Zentralbl. Bakteriol. Orig. A. 1974, 226, 153-167.
  • 52. Villarreal L. P., Defilippis V. R., Gottlieb K. A.: Acute and persistent viral life strategies and their relationship to emerging diseases. Virology 2000, 272, 1-6.
  • 53. Wang F., Guo X., Ge X., Wang Z., Chen Y., Cha Z., Yang H.: Genetic variation analysis of Chinese strains of porcine circovirus type 2. Virus Res. 2009, 145, 151-156.
  • 54. Wiederkehr D. D., Sydler T., Buergi E., Haessig M., Zimmermann D., Pospischil A., Brugnera E., Sidler X.: A new emerging genotype subgroup within PCV-2b dominates the PMWS epizooty in Switzerland. Vet. Microbiol. 2009, 136, 27-35.
  • 55. Xiao C. T., Halbur P. G., Opriessnig T.: Complete genome sequence of a novel porcine circovirus type 2b variant present in cases of vaccine failures in the United States. J. Virol. 2012, 86, 12469.
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.