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Czasopismo
2014 | 5 |
Tytuł artykułu

Zastosowanie bakteriofagów w ukierunkowanej terapii chorób bakteryjnych ryb - badania doświadczalne

Warianty tytułu
EN
Application of bacteriophages in targeted therapy of bacterial diseases in fish - an experimental study
Języki publikacji
PL
Abstrakty
EN
The increasing resistance of bacteria to available antibiotics constitutes one of the greatest challenges in intensive fish culture. The growing problem of chemotherapeutic resistance has revived interest in the potential use of bacterial viruses (bacteriophages) for therapy of bacterial diseases in fish. Bacteriophages are viruses specific for bacterial strains and are natural regulators of bacterial populations in waters. In the present study, we determined the influence of specific bacteriophages on mortality percentages after experimental challenges with the pathogenic bacteria Aeromonas hydrophila in rainbow trout. Healthy rainbow trout, weighing 50-100 g were used in the study. Bafador-1 with 1x108 PFU/ml or 1x109 PFU/ml concentrations of bacteriophages were used in immersion or injection at 12,24, or 48 h after experimental infections. The results showed that Bafador-1 reduced mortality after application in immersion or injection at a concentration of 1 LVm3 of water, or 0.2 ml per fish. The three experimental studies presented indicated that Bafador-1 is very effective in reducing mortality after experimental infection with the pathogenic bacteria A. hydrophila. The preliminary study showed that specific bacteriophages are very effective in specific therapy of bacterial diseases in fish.
Wydawca
-
Czasopismo
Rocznik
Numer
5
Opis fizyczny
s.11-15,wykr.,bibliogr.
Twórcy
autor
  • Zakład Patologii i Immunologii Ryb, Instytut Rybactwa Śródlądowego w Olsztynie, Olsztyn
autor
  • Proteon Pharmaceuticals S.A., Łódź
autor
  • Proteon Pharmaceuticals S.A., Łódź
autor
  • Katedra Mikrobiologii, Uniwersytet Warmińsko-Mazurski w Olsztynie, Olsztyn
autor
  • Katedra Mikrobiologii, Uniwersytet Warmińsko-Mazurski w Olsztynie, Olsztyn
autor
  • Zakład Patologii i Immunologii Ryb, Instytut Rybactwa Śródlądowego w Olsztynie, Olsztyn
autor
  • Zakład Patologii i Immunologii Ryb, Instytut Rybactwa Śródlądowego w Olsztynie, Olsztyn
autor
  • Zakład Patologii i Immunologii Ryb, Instytut Rybactwa Śródlądowego w Olsztynie, Olsztyn
  • Katedra Epizootiologii, Uniwersytet Warmińsko-Mazurski w Olsztynie, Olsztyn
Bibliografia
  • Boyd E.F., Davis B.M., Hochhut B. 2001 - Bacteriophage-bacteriophage interactions in the evolution of pathogenic bacteria - Trends Microbiol. 9: 137-144.
  • Cerveny K.E., DePaola A., Duckworth D.H., Gulig P.A. 2002 - Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran-treated mice - Infect. Immun. 70: 6251-6262.
  • Dąbrowska K., Świtała-Jeleń K., Opolski A., Weber-Dąbrowska B., Górski A. 2005 - Bacteriophage penetration in vertebrates - J. Appl. Microbiol. 98:7-13.
  • Dias R.S., Eller M.R., Duarte V.S., Pereira A.L., Silva C.C., Mantovani H.C., De Paula S.O. 2013 - Use of phages against antibiotic-resistant Sfaphylococcus aureus isolated from bovine mastitis - J. Anim. Sei. 91: 3930-3939.
  • Drulis-Kawa Z., Majkowska-Skrobek G., Maciejewska B., Delattre A.S., Lavigne R. 2012 - Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications - Curr. Prot. Pept. Seien. 13: 699-700.
  • Hanlon G.W. 2007 - Bacteriophages: an appraisal of their role in the treatment of bacterial infections - Inter. J. Antimicrob. Ag. 30:118-128.
  • Kumari S., Harjai K„ Chhibber S. 2009 - Bacteriophage treatment of burn wound infection caused by Pseudomonas aeruginosa PAO in BALB/c mice - Am. J. Biomed. Sei. 1: 385-394.
  • Kutateladze M., Adamia R. 2010 - Bacteriophages as potential new therapeutics to replace or supplement antibiotics - Trends Biotechnol. 28: 591-595.
  • Matsuzaki S., Rashel M., Uchiyama J., Sakurai S., Ujihara T., Kuroda M., Imai S. 2005 - Bacteriophage therapy: a revitalized therapy against bacterial infectious diseases - J. Infect. Chemother. 11: 211 -219.
  • Merril C.R., Biswas B., Carlton R., Jensen N.C., Creed G.J., Zullo S., Adhya S. 1996 - Long-circulating bacteriophage as antibacterial agents - Proc. Natl. Acad. Sei. U.S.A. 93: 3188-3192.
  • Morrison S., Rainnie D.J. 2004 - Bacteriophage Therapy: An Alternative to Antibiotic Therapy in Aquaculture - Can. Tech. Rep. Fish. Aquat. Sei. 2532.
  • Siwicki A.K., Morand M., Klein P. 1998 - Modulation of nonspecific defence mechanisms and protection against disease in fish - Acta Vet. Brno 67: 323-328.
  • Siwicki A.K., Kazuń K., Lepa A., Kazuń B. 2011 - Influence of 1,3-1,6-D-glucan (Leiber Beta-S) in diets on the effectiveness of anti-Enteric Red- mouth Disease (AquaVac ERM) vaccine in rainbow trout (Oncorhynchus mykiss) - Centn Eur. J. Immunol. 36: 212-214.
  • Skurnik M., Strauch E. 2006 - Phage therapy: facts and fiction - Int. J. Med. Microbiol. 296: 5-14.
  • Wagenaar J. A., Van Bergen M. A., Mueller M. A., WassenaarT. M., Carlton R. M. 2005 - Phage therapy reduces Campylobacter jejuni colonization in broilers - Vet. Microbiol. 109: 275-283.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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