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2015 | 75 | Supl. |
Tytuł artykułu

Streptozotocin and dimenthyl fumarate decreases plasma tumor necrosis factor Alpha concentration in rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
BACKGROUND AND AIMS: This study aims to determine if dimethyl fumarate (DMF), antioxidant having immunosuppressive properties, taken orally for three weeks will affect plasma tumor necrosis factor  alpha (TNF-α) concentration in an animal model of sporadic form of Alzheimer’s disease (sAD) induced by intracerebroventricular (icv) injection of betacytotoxic drug, streptozotocin (STZ). METHODS: Blood samples from young, male Wistar rats divided into four groups: STZ DMF (subjected to icv injection of STZ, fed with 0.4% DMF fodder), VEH DMF (subjected to icv injection of vehicle, fed with 0.4% DMF fodder), STZ CTR (subjected to icv injection of STZ, fed with standard fodder), VEH CTR (subjected to icv injection of vehicle, fed with standard fodder) were taken one hour after Morris water maze test finishing. Then, TNF-α concentration was determined with ELISA method using a Rat TNF-α ELISA Kit. RESULTS: Injections of STZ in rats being on the control feed (STZ/ CTR) significantly decreased (P≤0.05) the  plasma concentration of  TNF-α (22±2 pg/ml; mean±SE) as compared to the controls (VEH/CTR: 33±3 pg/ml). Moreover, within the STZ/DMF group, a significant (P≤0.01) decrease in the concentration of  TNF-α (22±0.8 pg/ml)  as compared to the controls  (VEH/DMF: 30±2 pg/ ml), was observed. CONCLUSION: The obtained results indicate that streptozotocin injection and feeding with dimethyl fumarate of the streptozotocininduced sAD rats reduce such a peripheral blood pro-inflammatory cytokine level as TNF-α.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
75
Numer
Opis fizyczny
p.S101
Twórcy
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-de943573-09c1-4d23-94bc-d4984dba1e19
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