Analiza porównawcza wpływu dwóch form antagonisty receptora glutaminianergicznego (mGluR) grupy I na stężenie katecholamin w ostrym bólu jelitowym u owcy

• Autorzy: Kania B.F. , Wronska D.

Warianty tytułu

EN

Comparative analysis of the influence of two forms of metabotropic glutamate receptor antagonist group I on plasma catecholamine concentration changes in acute colonal pain of sheep

• Języki publikacji: PL

Abstrakty

EN

The aim of this study was a comparative analysis between a five minute episode of mechanical colonal descending distension, which was provoked by the insertion of a balloon filled with 200 ml of water (CD200), and plasma CA concentration (epinephrine E, norepinephrine – NE and dopamine – DA) changes as a consequence of the sympatho-medullary-adrenal axis stimulation as well as nociceptive/stressoric effects. Furthermore, to note the comparative influence of premedication by metabotropic glutamate receptor antagonists by L-isomer (L-AP3) in the doses of 0.2, 0.4 and/or 0.8mg in toto and/or DL-AP3 racemate i.c.v. one min infusion in three different doses (4.0, 8.0 or 12.0 mg in toto) on the plasma CA concentration changes during 120 min of experimentation. The experiment was carried out in four series using 12 female sheep, Polish Merinos, in the anoestrus period (May–June). In the first series (six animals as a control group) the animals had a 200 μl 0.9% NaCl i.c.v. infusion. In the second series (six animals) they had a five min episode of CD by insertion of a balloon filled with 200 ml of water (CD200). In the third series of the experiment six animals had an i.c.v. DL-AP3 or L-AP3 infusion in three different doses (4.0, 8.0 or 12.0 and 0.2, 0.4 or 0.8 mg in toto, respectively), while in the fourth series, ten minutes before CD200, every week. Colon descending distension episodes lasting five min provoke a very repetitive, statistically significant increase of plasma CA concentration, a critical indicator – after cortisol – of the consequent stressoric effect of the sympatho-medullary adrenal axis stimulation. As a metabotropic nonspecific glutamate receptor type-1 antagonists DL-AP3 racemate and L-isomer AP3 certainly attenuate this elevation of CA, and can be an alternative drug in colonal pain caused by their wall having been distended in sheep. Clinical application of this AP3 must be confirmed by peripheral administration of the drugs.

Słowa kluczowe

PL

fizjologia zwierzat; owce; rozciaganie sciany okreznicy; bol jelitowy; zwalczanie bolu; antagonisci receptorow glutaminianergicznych; kwas amino-3-fosfonopropionowy; L-AP3; DL-AP3; badania krwi; surowica krwi; stezenie katecholamin

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2015
• Tom: 71
• Numer: 08
• Opis fizyczny: s.500-504,rys.,bibliogr.

Twórcy

autor

Kania B.F.

• Uniwersyteckie Centrum Medycyny Weterynaryjnej UJ-UR, Katedra Biotechnologii Zwierząt, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy i. Hogona Kołłątaja w Krakowie, Al.Mickiewicza 21, 30-059 Kraków

autor

Wronska D.

• Katedra Fizjologii i Endokrynologii Zwierząt, Wydział Biologii i Hodowli Zwierząt, Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Al.Mickiewicza 24/28, 30-059 Kraków

Bibliografia

• 1. Kania B. F., Ŝutiak V.: Influence of centrally administered Diltiazem on behavioural response, clinical symptoms, reticulo-ruminal contraction and plasma catecholamine level after experimentally induced duodenal distension in sheep. Res. Vet. Sci. 2011, 90, 291-297.
• 2. Kania B. F., Wrońska D.: Supraspinal basis of analgesic and clinical effects of the metabotropic glutamate mGluR1 antagonist during colonic distension in sheep. Small Rum. Res. 2014, 117, 84-93.
• 3. Kania B. F., Wrońska D., Wielgosz M.: Centrally administered DL-AP3 prevents the autonomic responses to colonic pain in sheep. Proc. XIII Middle Europ. Buiatric Cong., Beograd 2013, p. 334-341.
• 4. Kania B. F., Zaremba-Rutkowska M., Romanowicz K.: Doświadczalny stres jelitowy powodowany przez rozciąganie dwunastnicy u owcy. J. Anim. Feed Sci. 1999, 8, 233-245.
• 5. Okada S., Yamagushi-Shima N., Shimizu T., Arai J., Yorimitsu M., Yokotani K.: Centrally administered N-methyl-d-aspartate evokes the adrenal secretion of noradrenaline and adrenaline by brain thromboxane A2-mediated mechanisms in rats. Eur. J. Pharmacol. 2008, 586, 145-150.
• 6. Varney M. A., Gereau I. V.: Metabotropic glutamate receptor involvement in model of acute and persistent pain: prospects for the development on novel analgesics. Curr. Drug Targets CNS Neurol. Disord. 2002, 1, 283-296.
• 7. Wang Y., Fice D. S., Yeung P. K. F.: A simple high-performance liquid chromatography assay for simultaneous determination of plasma norepinephrine, epinephrine, dopamine and 3,4-dihroxyphenyl acetic acid. J. Pharmac. Biomed. Anal. 1999, 21, 519-525.