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2011 | 71 | 2 |
Tytuł artykułu

The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ^g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ^g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ^g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ^g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.
Słowa kluczowe
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-
Rocznik
Tom
71
Numer
2
Opis fizyczny
p.208-219,fig.,ref.
Twórcy
autor
  • Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
  • Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey
autor
  • Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey
autor
  • Departments of Physiology, Faculty of Medicine, University of Duzce, Duzce, Turkey
autor
  • Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey
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