The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

• Autorzy: Yildirim M. , Marangoz A. H. , Ayyildiz M. , Ankarali S. , Marangoz C.
• Języki publikacji: EN

Abstrakty

EN

In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ^g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ^g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ^g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ^g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 2
• Opis fizyczny: p.208-219,fig.,ref.

Twórcy

autor

Yildirim M.

• Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

autor

Marangoz A. H.

• Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey

autor

Ayyildiz M.

• Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey

autor

Ankarali S.

• Departments of Physiology, Faculty of Medicine, University of Duzce, Duzce, Turkey

autor

Marangoz C.

• Department of Physiology, Faculty ofMedicine, University of Ondokuz Mayis, Samsun, Turkey

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