EN
In the article are presented new discovered properties of spiramycin. It was found that spiramycin attaches firmly with a bacterial cell and therefore the activity of the antibiotic is long-lasting. This characteristic mechanism of the antibacterial activity of spiramycin is defined as a bacterial-pause. Due to pharmacokinetic properties which differ spiramycin from other macrolides it reaches a bactericidal concentration and characterizes by the longest half-time than other macrolides. Entrapping of spiramycin by macrophages and then its slow release support a control of infection. Spiramycin can cooperate with tetracyclines, aminoglucosidic antibiotics, polypeptide antibiotics, sulphonamides and nitroimidazoles. Spiramycin may be used in the treatment of the most infectious caused by Gram positive bacteria and mycoplasms. In the studies there was examined the usefulness of spiramycin in the treatment of experimental mycoplasmosis in broiler chickens, in duck staphylococcosis, infections of the upper respiratory tract, and skin and ears in dogs.