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2019 | 75 | 06 |

Tytuł artykułu

Efekty oddziaływania ektoiny na zwierzęta i człowieka

Warianty tytułu

EN
Effects of ectoine on animals and humans

Języki publikacji

PL

Abstrakty

EN
Some species of soil bacteria and most organisms living in extreme environments such as salt lakes or coal or salt mines have effective protective mechanisms that enable them to function under adverse conditions. A common way to protect against harmful environmental factors is the production and accumulation of substances with an osmoprotective effect. One of such substances is ectoine, or 1,4,5,6-tetrahydro-2-methyl-4-pyrimidine-carboxylic acid of an amphoteric nature. The effect of ectoin, mainly based on the binding of water molecules, has found wide application in the protection of macromolecules and cells. This work is a review of the use of this amino acid in human and veterinary medicine.

Wydawca

-

Rocznik

Tom

75

Numer

06

Opis fizyczny

s.335-339,bibliogr.

Twórcy

autor
  • Instytut Biologicznych Podstaw Produkcji Zwierzęcej, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 13, 20-950 Lublin
autor
  • Instytut Biologicznych Podstaw Produkcji Zwierzęcej, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 13, 20-950 Lublin
autor
  • Instytut Biologicznych Podstaw Produkcji Zwierzęcej, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 13, 20-950 Lublin

Bibliografia

  • Bazazzadegan N., Shasaltaneh M. D., Saliminejad K., Kamali K., Banan M., Nazari R., Khorshid H. R. K.: Effects of Ectoine on Behavior and Candidate Genes Expression in ICV-STZ Rat Model of Sporadic Alzheimer’s Disease. Adv. Pharm. Bull. 2017, 7, 629.
  • Bownik A.: Daphnia swimming behaviour as a biomarker in toxicity assessment: A review. Sci. Total Environ. 2017, 601, 194-205.
  • Bownik A., Stępniewska Z.: Obećavajuća zaštitna svojstva ektoina u ljudi i životinja. Arh. Hig. Rada Toksikol. 2016, 67, 260-264.
  • Bownik A., Stępniewska Z., Skowroński T.: Effects of ectoine on behavioural, physiological and biochemical parameters of Daphnia magna. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 2015, 168, 2-10.
  • Budanur D. T., Zibandeh N., Genç D., Gökalp M., Kaşali K., Akkoç T., Sepet E.: Effect of CDMEM media containing Ectoine on human periodontal ligament mesenchymal stem cell survival and differentiation. Dent. Traumatol. 2018.
  • Dwivedi M., Brinkkötter M., Harishchandra R. K., Galla H. J.: Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: artificial lipid films. Bba Biomemb. 2014, 1838, 2716-2727.
  • Graf R., Anzali S., Buenger J., Pfluecker F., Driller H.: The multifunctional role of ectoine as a natural cell protectant. Clin. Dermatol. 2008, 26, 326-333.
  • Hahn M. B., Meyer S., Schröter M. A., Kunte H. J., Solomun T., Sturm H.: DNA protection by ectoine from ionizing radiation: molecular mechanisms. Phys. Chem. Chem. Phys. 2017, 19, 25717-25722.
  • Hofmann N., Sun H., Chatterjee A., Saha D., Glasmacher B.: Thermal pretreatment improves viability of cryopreserved human endothelial cells. Biopreserv. Biobank. 2015, 13, 348-355.
  • Hoymann H. G., Bilstein A., Bernal F., Stoehr T., Lentzen G.: Therapeutic effect of ectoine in an experimental model of allergic asthma. XXVIII EAACI Congress, Warsaw 2009.
  • Jamwal V. S., Mishra S., Kumar Reddy D. S., Bansal D. D., Javed S., Singh A., Kumar Gautam H., Arora R.: Evaluation of antioxidant and radioprotective properties os hydroxyectoine. Trakia J. Sci. 2013, 10, 25-33.
  • Jorge C. D., Borges N., Bagyan I., Bilstein A., Santos H.: Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare. Extremophiles 2016, 20, 251-259.
  • Kanapathipillai M., Lentzen G., Sierks M., Park C. B.: Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer’s β-amyloid. FEBS letters 2005, 579, 4775-4780.
  • Kunte H. J., Lentzen G., Galinski E. A.: Industrial production of the cell protectant ectoine: Protection mechanisms, processes, and products. Curr. Biotechnol. 2014, 3, 10-25.
  • Lentzen G., Schwarz T.: Extremolytes: natural compounds from extremophiles for versatile applications. App. Microbiol. Biot. 2006, 72, 623-634.
  • Lippert K., Galinski E. A.: Enzyme stabilization be ectoine-type compatible solutes: protection against heating, freezing and drying. Appl. Microbiol. Biotechnol. 1992, 37, 61-65.
  • Ma Y., Wang Q., Xu W., Liu X., Gao X., Zhang Y.: Stationary phase-dependent accumulation of ectoine is an efficient adaptation strategy in Vibrio anguillarum against cold stress. Microbiol. Res. 2017, 205, 8-18.
  • Müller D., Lindemann T., Shah-Hosseini K., Scherner O., Knop M., Bilstein A., Mösges R.: Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial. Eur. Arch. Otorhinolaryngol. 2016, 273, 2591-2597.
  • Pastor J. M., Bernal V., Salvador M., Argandoña M., Vargas C., Csonka L., Cánovas M.: Role of central metabolism in the osmoadaptation of the halophilic bacterium Chromohalobactersalexigens. J. Biol. Chem. 2013, 288, 17769-17781.
  • Patel T. R., Winzor D. J., Scott D. J.: Allowance for radial dilution in evaluating the concentration dependence of sedimentation coefficients for globular proteins. Eur. Biophys J. 2018, 47, 291-295.
  • Pollock K., Budenske J. W., McKenna D. H., Dosa P. I., Hubel A.: Algorithmdriven optimization of cryopreservation protocols for transfusion model cell types including Jurkat cells and mesenchymal stem cells. J. Tiss. Eng. Regen. M. 2017, 11, 2806-2815.
  • Refaat R., Sarhan D., Kotb M., El-Abd E., El-Bassiouni E.: Post-irradiation protective effects of ectoine on brain and testicles in male mice. Pharmacol. Rep. 2017.
  • Reshetnikov A. S., Khmelenina V. N., Trotsenko Y. A.: Characterization of the ectoine biosynthesis genes of haloalkalotolerant obligate methanotroph “Methylomicrobium alcaliphilum 20Z”. Arch. Microbial. 2006, 184, 286-297.
  • Reshetnikov A. S., Khmelenina V. N., Mustakhimov I. I., Kalyuzhnaya M., Lidstrom M., Trotsenko Y. A.: Diversity and phylogeny of the ectoine biosynthesis genes in aerobic, moderately halophilic methylotrophic bacteria. Extremophiles 2011, 15, 653.
  • Reuter S., Gupta S. C., Chaturvedi M. M., Aggarwal B. B.: Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biol. Med. 2010, 49, 1603-1616.
  • Salmannejad F., Nafissi-Varcheh N.: Ectoine and hydroxyectoine inhibit thermal-induced aggregation and increase thermostability of recombinant human interferon Alfa2b. Eur. J. Pharm. Sci. 2017, 97, 200-207.
  • Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G., Seitz H., Oesterhelt D.: A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581T. Environ. Microbiol. 2011, 13, 1973-1994.
  • Sheikhpour M., Hatamian A., Yazdian F., Sadeghi A., Azizi M.: 0TAntiproliferative effects 0T5T of 5T Ectoine and Hydroxyectoine 5 Ton human 0T5Tlung cancer cells. I. Ch.E. C. Kish, Iran 2014, 2, 24-27.
  • Stiller L. M., Galinski E. A., Witt E. M.: Engineering the Salt-Inducible Ectoine Promoter Region of Halomonaselongata for Protein Expression in a Unique Stabilizing Environment. Genes 2018, 9, 184.
  • Sun H., Glasmacher B., Hofmann N.: Compatible solutes improve cryopreservation of human endothelial cells. Cryoletters 2012, 33, 485-493.
  • Sydlik U., Peuschel H., Paunel-Görgülü A., Keymel S., Krämer U., Weissenberg A., Bilstein A.: Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur. Respir. J. 2013, 41, 433-442.
  • Widderich N., Kobus S., Höppner A., Riclea R., Seubert A., Dickschat J. S., Bremer E.: Biochemistry and crystal structure of ectoine synthase: a metal-containing member of the cupin superfamily. PloS one 2016, 11, e0151285.
  • Witt E. M., Davies N. W., Galinski E. A.: Unexpected property of ectoine synthase and its application for synthesis of the engineered compatible solute ADPC. App. Microbial. Biot. 2011, 91, 113.
  • Zaccai G., Bagyan I., Combet J., Cuello G. J., Demé B., Fichou Y., Gallat F.-X., Josa V. M. G., von Gronau S., Haertlein M., Martel A., Moulin M., Neumann M., Weik M., Oesterheltb D.: Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane. Sci. Rep. 2016, 6, 31343.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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