Characterization and SNP identification of goat TYRP1 gene

• Autorzy: Zheng H. , Li L. , Li X. , Zhou R. , Ren Y. , Xuan F. , Zhang J. , Shen Z. , Zhao H.
• Języki publikacji: EN

Abstrakty

EN

As a member of tyrosinase-related family, tyrosinase-related protein-1 (TYRP1) has been reported to play an important role in melanin biosynthetic pathway in some species, but little is known about its role in goat. In this study, almost complete goat TYRP1 gene (17554 bp, HMO70243) encompassing complete CDS was identified, the coding region amounting to 1614 bp, distributed in 7 exons (2-8), and intron 5 was found to possess GC-AG as its splice sites. Dozens of SNPs as well as simple sequence repeat (SSR) motifs were detected in goat TYRP1 gene, in which 4 SSR motifs in intron 5 are combined in a tandem. Correlation analysis showed the allele A to be advantageous compared to C at site g.1263A>C and allele C compared to T at g.1428C>T, implyimg that haplotype AC is in favour of eumelanin biosynthesis, and haplotype CC is in favour of pheomelanin formation.Marked deficiency of heterozygotes occurred in Nanjiang Yellow Goat Black strain and Nanjiang Yellow Goat Fast Grow strain, indicating the high inbreeding in both strains.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2012
• Tom: 30
• Numer: 2
• Opis fizyczny: p.159-168,fig.,ref.

Twórcy

autor

Zheng H.

• College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071000, Hebei,China

autor

Li L.

autor

Li X.

autor

Zhou R.

autor

Ren Y.

autor

Xuan F.

autor

Zhang J.

autor

Shen Z.

autor

Zhao H.

Bibliografia

• BERRYERE T.G., SCHMUTZ S.M., SCHIMPF R.J., COWAN C.M., POTTER J., 2003 – TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow? Animal Genetics 34,169-175.
• BOX N.F., WYETH J.R., MAYNE C.J., O’GORMAN L.E., MARTIN N.G., STURM R.A., 1998 – Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinaserelated protein 1. Mammalian Genome 9, 50-53.
• CARGILL E.J., FAMULA T.R., SCHNABEL R.D., STRAIN G.M., MURPHY K.E., 2005 –.The color of a Dalmatian’s spots: linkage evidence to support the TYRP1 gene. BMC Veterinary Research 1, 1.
• CHEN H., SALOPEK T.G., JIMBOW K.J., 2001 – The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1). Journal of Investigative Dermatology Symposium Proceedings 6, 105-114.
• GIRARDOT M., GUIBERT S., LAFORET M.P., GALLARD Y., LARROQUE H., OULMOUDEN A., 2006 – The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene. Pigment Cell Research 19, 346-355.
• GRATTEN J., BERALDI D., LOWDER B. V., MCRAE A.F., VISSCHER P.M., PEMBERTON J.M.,and Slate J., 2007 –TYRP1 is responsible for coat-colour polymorphism in a Compelling evidence that a single nucleotide substitution in free-living population of Soay sheep. Proceedings of the Royal Society B: Biological Science 274, 619-626.
• JACKMAN M.P., HAJNAL A., LERCH K., 1991 – Albino mutants of Streptomyces glaucescens tyrosinase. Biochemical Journal 274 (Pt 3), 707-713.
• KITAMURA-ABE S., ITOH H., WASHIO T., TSUTSUMI A., TOMITA M., 2004 – Characterization of the splice sites in GT-AG and GC-AG introns in higher eukaryotes using full-length cDNAs. The Journal of Bioinformatics and Computational Biology 2, 309-331.
• KUZUMAKI T., MATSUDA. A., WAKAMATSU K., ITO S., ISHIKAWA K., 1993 – Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes. Experimental Cell Research 207, 33-40.
• LI X.L., AlESSIO V., 2004 – Genetic diversity of Chinese indigenous goat breeds based on microsatellite markers. Journal of Animal Breeding and Genetics 121, 350-355.
• LYONS L.A., FOE I.T., RAH H.C., GRAHN R.A., 2005 – Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mammalian Genome 16, 356-366.
• MANGA P., KROMBERG J.G., BOX N.F, STURM R.A., JENKINS T., RAMSAY M., 1997 –Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene. The American Journal of Human Genetics 61, 1095-1101.
• NEFF M.M., NEFF J.D., CHORY J., PEPPER A.E., 1998 – dCAPS, a simple technique for the genetic analysis of single nucleotide polymorphisms: experimental applications in Arabidopsis thaliana genetics. The Plant Journal 14, 387-392.
• RIEDER S., TAOURIT S., MARIAT D., LANGLOIS B., GUERIN G., 2001 – Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mammalian Genome 12, 450-455.
• SCHMUTZ S.M, BERRYERE T.G., 2007 – Genes affecting coat colour and pattern in domestic dogs: a review. Animal Genetics 38, 539-549.
• SCHMUTZ S.M., BERRYERE T.G., GOLDFINCH A.D., 2002 – TYRP1 and MC1R genotypes and their effects on coat color in dogs. Mammian Genome 13, 380-387.
• STEPHENS M., SMITH N.J., DONNELLY P., 2001 – A new statistical method for haplotype reconstruction from population data. The American Journal of Human Genetics 68, 978-989.
• YU C., ZHANG G.J., 2005 – Groups breeding and reproduction in Nanjiang goat. China Animal Husbandry & Veterinary Medicine 32, 36-39.
• ZHENG H.Q., LI X.L., Zhou R.Y., LI L.H., GUO X.L., KANG J.F., LI D.F., 2010 – Bioinformatics analysis of tyrosinase-related protein 1 gene (TYRP1) from different species. Frontiers of Agriculture in China 4, 109-115

Uwagi

PL

Rekord w opracowaniu