Molecular factors involved in the development of diabetic foot syndrome

• Autorzy: Bruhn-Olszewska B. , Korzon-Burakowska A. , Gabig-Ciminska M. , Olszewski P. , Wegrzyn A. , Jakobkiewicz-Banecka J.
• Języki publikacji: EN

Abstrakty

EN

 Diabetes is one of the major challenges of modern medicine, as it is considered a global epidemic of the XXI century. The disease often leads to the development of serious, health threatening complications. Diabetic foot syndrome is a characteristic set of anatomical and molecular changes. At the macroscopic level, major symptoms are neuropathy, ischemia and chronic ulceration of the lower limb. In every third patient, the neuropathy develops into Charcot neuroarthropathy characterized by bone and joints deformation. Interestingly, all these complications are a result of impaired healing processes and are characteristic for diabetes. The specificity of these symptoms comes from impaired molecular mechanisms observed in type 1 and type 2 diabetes. Decreased wound and fracture healing reflect gene expression, cellular response, cell functioning and general metabolism. Here we present a comprehensive literature update on the molecular factors contributing to diabetic foot syndrome.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 4
• Opis fizyczny: p.507-513,fig.,ref.

Twórcy

autor

Bruhn-Olszewska B.

• Department of Molecular Biology, University of Gdansk, Gdańsk, Poland

autor

Korzon-Burakowska A.

• Department of Diabetology and Hypertension, Medical University of Gdańsk, Gdańsk, Poland

autor

Gabig-Ciminska M.

• Department of Molecular Biology, University of Gdansk, Gdańsk, Poland
• Laboratory of Molecular Biology (affiliated with the University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Gdańsk, Poland

autor

Olszewski P.

• Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

autor

Wegrzyn A.

• Department of Microbiology, University of Szczecin, Szczecin, Poland

autor

Jakobkiewicz-Banecka J.

• Department of Molecular Biology, University of Gdansk, Gdańsk, Poland

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