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2012 | 59 | 4 |

Tytuł artykułu

Some heterocyclic thione derivatives exhibit anticoccidial activity by inhibiting glycosidases

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
 Coccidiosis is one of the most common parasitic diseases affecting many species of domestic animals. This disease has a major economic significance and the search for new compounds having anticoccidial activity is of great importance. In this article, different levels of protection from coccidian infection by Eimeria stiedae were developed in rabbits by treatment with compounds incorporating the skeleton of thiourea. These compounds include 4,5-diphenylimidazole-2-thione (1), 4,5-Diphenyl-1,2,4-triazole-3-thiol (2) and 5-(2-Hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thiol (3) compared to the anticoccidial drug toltrazuril as a reference compound. Compounds 1-3 inhibit coccidiosis-induced activity of α-glucosidase. The protection from coccidial infection by compound 1 was higher than that shown for compounds 2 and 3. These data suggest that diazole and triazole thione derivatives have a mimetic effect for anticoccidial drugs through their inhibition of glycosidases.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

59

Numer

4

Opis fizyczny

p.575-580,fig.,ref.

Twórcy

autor
  • Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
  • Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
autor
  • Biochemistry Department, Edfina Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt
  • Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

Bibliografia

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Bibliografia

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