A role of ghrelin in cancerogenesis

• Autorzy: Majchrzak K. , Szyszko K. , Pawlowski K. M. , Motyl T. , Krol M.
• Języki publikacji: EN

Abstrakty

EN

Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.

Słowa kluczowe

EN

ghrelin; cancerogenesis; growth hormone secretagogue receptor; cancer; mammary cancer; veterinary oncology; oncology; dog; animal disease

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2012
• Tom: 15
• Numer: 1
• Opis fizyczny: p.189-197,fig.,ref.

Twórcy

autor

Majchrzak K.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - WULS, Nowoursynowska 159, 02-776 Warsaw, Poland

autor

Szyszko K.

autor

Pawlowski K. M.

autor

Motyl T.

autor

Krol M.

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