The bacteriostatic effect of erythritol on canine periodontal disease–related bacteria

• Autorzy: Tochio T. , Makida R. , Fujii T. , Kadota Y. , Takahashi M. , Watanabe A. , Funasaka K. , Hirooka Y. , Yasukawa A. , Kawano K.
• Języki publikacji: EN

Abstrakty

EN

Erythritol helps both prevent and improve periodontal disease and is therefore widely used for dental care in humans. However, only a few studies have investigated the effects of erythritol on periodontal disease in animals. We hypothesized that erythritol could be used to prevent and improve periodontal disease also in canines and investigated the effects of erythritol on canine periodontal disease–related pathogenic bacteria using both in vitro and in vivo methods. The effect of erythritol on the proliferation of Porphyromonas gulae, which is reportedly associated with canine periodontal disease, was investigated in vitro. In addition, a 4-week intervention trial using an external gel preparation containing 5% erythritol was performed in canines with mild periodontal disease; changes in the microbiota around periodontal lesions were investigated using next-generation sequencing and bioinformatics analysis. The growth of P. gulae was significantly suppressed by erythritol in vitro. In the intervention study, the Shannon index, an indicator of the species distribution α-diversity, and the occupancy of several canine periodontal disease – related bacteria (P. gulae, P. cangingivalis) were significantly decreased in periodontal lesions. Based on the results of in vitro and in vivo studies, we conclude that, as in humans, erythritol has bacteriostatic effects against periodontal disease – related bacteria in canines.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2022
• Tom: 25
• Numer: 1
• Opis fizyczny: p.75-82,fig.,ref.

Twórcy

autor

Tochio T.

• B Food Science Co., Ltd., 24-12, Kitahama-machi, Chita, Aichi 478-0046, Japan
• Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi 470-1192, Japan

autor

Makida R.

• B Food Science Co., Ltd., 24-12, Kitahama-machi, Chita, Aichi 478-0046, Japan

autor

Fujii T.

• B Food Science Co., Ltd., 24-12, Kitahama-machi, Chita, Aichi 478-0046, Japan

autor

Kadota Y.

• B Food Science Co., Ltd., 24-12, Kitahama-machi, Chita, Aichi 478-0046, Japan

autor

Takahashi M.

• B Food Science Co., Ltd., 24-12, Kitahama-machi, Chita, Aichi 478-0046, Japan

autor

Watanabe A.

• Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi 470-1192, Japan

autor

Funasaka K.

• Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi 470-1192, Japan

autor

Hirooka Y.

• Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi 470-1192, Japan

autor

Yasukawa A.

• Kamishakujii Veterinary Medical Hospital, 1-4-13, Sekimachi-Higashi, Nerima-ku, Tokyo 177-0052, Japan

autor

Kawano K.

• Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake, Aichi 470-1192, Japan
• Tokyo Animal Allergy Center, 4-23-15, Kurihara, Adachi-ku, Tokyo 123-0842, Japan

Identyfikatory

DOI

10.24425/pjvs.2022.140843