Collagen types I and II distribution: a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised rabbit knee joints

• Autorzy: Aldahmash A.M. , El Fouhil A.F. , Mohamed R.A. , Ahmed A.M. , Atteya M. , Al Sharawy S.A. , Qureshi R.A.
• Języki publikacji: EN

Abstrakty

EN

The objective of the present work was to study changes in collagen type I and type II distribution in the articular cartilage of immobilised and remobilised rabbit knee joints. Twenty-four adult male rabbits were divided into three groups. One of the groups was a control group with free movement. The right knee joints of animals of the other two groups were immobilised for 4 weeks, followed by a period of 10 weeks of remobilisation for animals of group 3. Collagen type I and type II in the articular cartilage of tibial medial condyle of the right knee joint were estimated immunohistochemically in all groups. A degenerative process was evident after 4 weeks of immobilisation of rabbit knee joint leading to a partial shift in the density of collagen composition from type II to type I. After a period of 10 weeks of remobilisation, regenerative processes, evidenced by a restoration of collagen type II to normal, proceeded on top of degenerative processes, evidenced by the significantly higher content of collagen type I compared with normal. The present study pointed to the importance of assessment of collagen distribution as a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised joints. (Folia Morphol 2015; 74, 2: 169–175)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2015
• Tom: 74
• Numer: 2
• Opis fizyczny: p.169-175,fig.,ref.

Twórcy

autor

Aldahmash A.M.

• Department of Anatomy and Embryology, College of Medicine, King Saud University, PO Box 2925(28), Riyadh 11461, Saudi Arabia,

autor

El Fouhil A.F.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Mohamed R.A.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
• Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt

autor

Ahmed A.M.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Atteya M.

• Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
• Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt

autor

Al Sharawy S.A.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

autor

Qureshi R.A.

• Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Identyfikatory

DOI

10.5603/FM.2015.0027