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2018 | 10 | 2 |
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The effect of ‪nicotine on oral health

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Background:Nicotine absorbed by the skin and also by the digestive, respiratory and excretory systems is one of the most known toxins found in tobacco. ‪This work reviews available literature on the influence of nicotine on human health, and in particular on the oral cavity. Material/Methods: ‪A review of literature related to the topic of the paper. Results:Numerous studies indicate that nicotine adversely affects human health. ‪It exerts a negative effect at the cellular level by modifying metabolism, and disturbs the interactions between tissues, which strongly promotes the formation of cancer-like changes. Nicotine causes numerous pathologies in the respiratory, immune, and cardiovascular systems leading to a number of metabolic disorders. Conclusions: The intake of nicotine contained in tobacco products has a particularly negative effect on the oral cavity.‬ It accelerates periodontitis, with weaker clinical symptoms associated with resistance to conventional treatment.‬ ‪In addition, nicotine changes the oral cavity microflora, increasing the amount of harmful bacteria and pathogenic fungi.‬
Słowa kluczowe
  • Department of Oral Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Department of Oral Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Department of Oral Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Department of Oral Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • Faculty of Physical Education, University of Rzeszow, Rzeszow, Poland
  • Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • [1] Pardo-Tomas J, Botany. In: Goodman J. Tabacco in history and culture. An encyclopedia. Charles Scribner’s Son, Detroit; 2005, 85-8.
  • [2] Grzybowski A. Historia tytoniu w Europie [The history of tobacco in Europe]. Herba Polonica. 2006:52(4);146-152. Polish.
  • [3] World Health Organization. The history of tobacco. [Accessed on 10.02.2018].
  • [4] Musk AW, Klerk NH. History of tobacco and health. Respirology. 2003;8:286-290.
  • [5] Darvishzadeh R, Mirzaei L, Maleki HH, Laurentin H, Alavi SR. Genetic variation in oriental tobacco (Nicotiana tabacum L.) by agro-morphological traits and simple sequence repeat markers. Rev Ciênc Agron. 2013;4(2):347-355.
  • [6] World Health Organization. Media centre tobacco fact sheet. [Accessed on 10.02.2018].
  • [7] Szczęch B, Dyzmann-Sroka A, Kubiak A, Trojanowski M, Malicki J. Analiza świadomości zdrowotnych skutków palenia tytoniu wśród wybranych grup społecznych [Analysis of awareness of health consequences of tobacco use among selected social groups]. Probl Hig Epidemiol. 2014;95(4):871-879. Polish.
  • [8] Florek E. Skład chemiczny i kancerogeny dymu tytoniowego [Chemical and carcinogen composition of tobacco smoke]. Alkoholizm i Narkomania. 1999;3(36):333-347. Polish.
  • [9] Schievelbein H, Eberhardt R, Löschenkohl K, Rahlfs V, Bedall FK. Absorption of nicotine through the oral mucosa I. Measurement of nicotine concentration in the blood after application of nicotine and total particulate matter. Inflamm Res. 1973;3:254-8.
  • [10] Nakajima M, Tanaka E, Kwon JT, Yokoi T. Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes. Drug Metab Dispos. 2002;30:1484-90.
  • [11] Grando SA. Connections of nicotine to cancer. Nat Rev Cancer. 2014;14:419-29.
  • [12] Vezina P, McGehee DS, Green WN. Exposure to nicotine and sensitization of nicotine-induced behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1625-38.
  • [13] Bruin JE, Kellenberger LD, Gerstein HC, Morrison KM, Holloway AC. Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: Identifying critical windows of exposure. J Endocrinol 2007;194:171-8.
  • [14] Slotkin TA, Seidler FJ, Spindel ER. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: Amelioration by vitamin C. Neurotoxicol Teratol. 2011;33:431-434.
  • [15] Xu J, Huang H, Pan C, Zhang B, Liu X, Zhang L. Nicotine inhibits apoptosis induced by cisplatin in human oral cancer cells. Int J Oral Maxillofac Surg. 2007;36:739-44.
  • [16] Szymańska JA, Frydrych B, Bruchajzer E. Nikotyna. Dokumentacja dopuszczalnych wielkości narażenia zawodowego [Nicotine. Documentation of occupational exposure limits]. Podstawy i Metody Oceny Środowiska Pracy. 2007:2(52);121-154. Polish.
  • [17] Benowitz NL, Steven GG. Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy. JACC. 1997;7(29):1422-31.
  • [18] Jaiswal SJ, Pilarski JQ, Harrison CM, Fregosi RF. Developmental nicotine exposure alters AMPA neurotransmission in the hypoglossal motor nucleus and pre-Botzinger complex of neonatal rats. J Neurosci. 2013;33:2616-25.
  • [19] Sopori ML, Kozak W, Savage SM, et al. Effect of nicotine on the immune system: Possible regulation of immune responses by central and peripheral mechanisms. Psychoneuroendocrinology. 1998;23:189-204.
  • [20] Tirgan N, Kulp GA, Gupta P, et al. Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. Exp Diabetes Res. 2012;2012:349320.
  • [21] Kadakia SC, De La Baume HR, Shaffer RT. Effects of transdermal nicotine on lower esophageal sphincter and esophageal motility. Dig Dis Sci. 1996;41:2130-4.
  • [22] Jain G, Jaimes EA. Nicotine signaling and progression of chronic kidney disease in smoker. Biochem Pharmacol. 2013;86(8):1215-1223.
  • [23] Zhou J, Olson BL, Windsor LJ. Nicotine increases the collagen-degrading ability of human gingival fibroblasts. J Periodont Res. 2007;42:228-235.
  • [24] Tomek RJ, Rimar S, Eghbali-Webb M. Nicotine regulates collagen gene expression, collagenase activity, and DNA synthesis in cultured cardiac fibroblasts. Mol Cell Biochem. 1994;136:97-103.
  • [25] Vincent RG, Marchetta F. The relationship of the use of tobacco and alcohol to cancer of the oral cavity, pharynx, or larynx. Am J Surg. 1963;106:501-505.
  • [26] Zhang M, Zhao YH, Tang XF, Hou M. Effect of nicotine on the proliferation and cell apoptosis of oral squamous cell carcinoma SCC15 cells. Zhonghua Kou Qiang Yi Xue Za Zhi. 2012;47:233-37.
  • [27] Reichart PA. Primary prevention of mouth carcinoma and oral precancerous conditions. Mund Kiefer Gesichtschir. 2000;4:357-64.
  • [28] Pindborg JJ, Renstrup G, Jolst O, Roed-Peterson B. Studies in oral leukoplakia: a preliminary report on the period prevalence of malignant transformation in leukoplakia based in a follow- up study of 248 patients. J Am Dent Assoc. 1968;76:767-71.
  • [29] Brouns E, Baart J, Karagozoglu KH, Aartman I, Bloemena E, van der Waal I. Malignant transformation of oral leukoplakia in a well-defined cohort of 144 patients. Oral Dis. 2014;20:19-24.
  • [30] Ho MW, Risk JM, Woolgar JA, et al. The clinical determinants of malignant transformation in oral epithelial dysplasia. Oral Oncol. 2012;48:969-976.
  • [31] Amagasa T, Yamashiro M, Uzawa N. Oral premalignant lesions: from a clinical perspective. Int J Clin Oncol. 2011;16:5-14.
  • [32] Martin JL. Leukoedema: a review of the literature. J Natl Med Assoc. 1992;84(11): 938-940.
  • [33] Russ HC. Oral leukoplakia: a review of the literature. J Oral Surg. 1957;15:40-49.
  • [34] Wallace RH. The relationship between cigarette smoking and dental implant failure. Eur J Prosthodont Restor Dent. 2000;8:103-6.
  • [35] Mosley LH, Finseth F. Nicotine and its effect on wound healing. Plast Reconstr Surg. 1978;61:570-575.
  • [36] Uedelhoven WM, Rutzel A, Messe CO, Weber PC. Smoking alters thromboxane metabolism in man. Biochim Biophys Acta. 1991;1081:197-201.
  • [37] Twito D, Sade P. The effect of cigarette smoking habits on the outcome of dental implant treatment. Peer J. 2014;2:546.
  • [38] Ness L, Rosekrans DL, Welford JF. An epidemiologic study of factors affecting extrinsic staining of teeth in an English population. Commun Dent Oral Epidemiol. 1977;5:55-60.
  • [39] Agnihotri R, Gaur S. Implications of tobacco smoking on the oral health of older adults. Geriatr Gerontol Int. 2014;14:526–540.
  • [40] Bouquot DJ, Schroeder K. Oral effects of tobacco abuse. J Am Dent Inst Cont Educ. 1992;43:3-17.
  • [41] Albandar JM, Streckfus CF, Adesanya MR, Winn DM. Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss. J Periodontol. 2000;71:1874-1881.
  • [42] Michele K, Beaumert AH, Johnson G, et al. The effect of smoking on the response to periodontal terapy. J Clin Periodontol. 1994;21:91-97.
  • [43] Axelsson P, Paulander J, Lindhe J. Relationship between smoking and dental status in 35, 50, 65, and 75 years old individuals. J Clin Periodontol. 1998;25:297-305.
  • [44] Maciąg W, Bachanek T. Wpływ alkoholu i nikotyny na stan zdrowia jamy ustnej [Effect of alcohol and nicotine on oral health]. Magazyn Stomat. 2006;16,11:28-29. Polish.
  • [45] Sakki T, knuuttila M. Controlled study of the association of smoking with lactobacilli, mutans streptococci and yeasts in saliva. Eur J Oral Sci. 1996;104:619-22.
  • [46] Reichart PA, Schmidtberg W, Samaranyake LP, Scheifele C. Betel quid associated oral lesion and oral candida species in female Cambodian cohort. J Pathol Med. 2002;31:468-72.
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