Key to Immortality-the potential role of adult pluripotent stem cells (VSELs) in tissue and organ regeneration

• Autorzy: Zuba-Surma E.
• Języki publikacji: EN

Abstrakty

EN

The main purpose of regenerative medicine is to improve irreversible damage of organs including brain and neural tissues by harnessing the capacity of stem cells in process of tissue repair and renewal. Several types of stem cells including mesenchymal stem cells, hematopoietic stem cells as well as neural cells differentiated from embryonic stem cell lines have been postulated as potential source of therapeutical cells. Recently, it has been found that murine bone marrow (BM) contains a mobile population of Oct-4+CXCR4+SSEA-1+Sca-1+LinCD45- very small embryonic like stem cells (VSELs) that may be mobilized into peripheral blood due to the tissue injury including stroke. The number of these cells in circulation may be also efficiently increased after pharmacological mobilization such as administration of granulocyte colony stimulating factor (G-CSF). VSELs have been also identified in other adult tissues and organs and interestingly, the highest number of cells resembling VSEL phenotype was found in brain tissue. Recent molecular studies investigating the genetic and epigenetic status of VSELs indicate that these cells represent a mobile population of epiblast/ germ line derived stem cells and play an important role as organresiding reserve population of pluripotent stem cells that gives rise to stem cells committed to particular organs and tissues - including neural tissue. Moreover, a similar population of very small CXCR4+CD133+CD34+SSEA-4+Oct-4+Lin-CD45- cells resides also in human bone marrow and umbilical cord blood. Such population may be also detected in peripheral blood of patients with acute myocardial infarction, stroke, unhealed wound as well as suffering with tumors, which injuries and diseases may trigger mobilization of VSELs into blood. It has been shown that VSELs reveal the regenerative potential when injected into injured tissues in vivo, in experimental model of heart ischemia and reperfusion. We conclude that VSELs which exhibit pluripotent characteristics, are mobilized to blood due to a tissue injury and possess regenerative capacity in injured tissues, may represent promising population for future applications regenerative medicine including novel therapies for brain injury treatment.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 1
• Opis fizyczny: p.168

Twórcy

autor

Zuba-Surma E.

• Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland