PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 19 | 3 |
Tytuł artykułu

Toxicity of salinomycin and narasin in turkeys

Treść / Zawartość
Warianty tytułu
PL
Toksyczność salinomycyny i narazyny u indyków
Języki publikacji
EN
Abstrakty
EN
Coccidiosis continues to be one of the most serious diseases in poultry breeding, causing major economic losses in this industry. Many trials are conducted to prevent and control this disease. However, only a few medications are approved for use in the prevention and treatment of coccidiosis. Ionophore coccidiostats (e.g. salinomycin and narasin) act by altering the transmembrane movement of monovalent or divalent ions (Na+, K+, Ca2+, Mg2+, Rb+, Cs+), resulting in altered ionic gradients and disturbed physiological processes in coccidia. In broiler and turkey breeding, these agents are used for nearly the whole fattening period. Ionophore coccidiostats have a narrow safety margin. Their toxicity is probably due to a disturbed ion balance or to oxidative damage. Although ionophore coccidiostats are considered to be relatively safe for target animals, there are numerous reports of poisoning cases caused by these medications in birds. This paper summarizes the current state of knowledge on the toxicity of salinomycin and narasin in turkeys. It reviews the data concerning the symptoms, mortality rate and possible causes of poisoning with these agents. Moreover, the paper discusses the legal regulations regarding the use of these drugs in poultry.
PL
Kokcydioza jest nadal uznawana za jedną z najważniejszych chorób w hodowli drobiu, stanowiąc główną przyczynę strat ekonomicznych w przemyśle drobiarskim. Podejmuje się wiele działań na rzecz zapobiegania i kontroli tej choroby. Do profilaktyki i terapii kokcydiozy zatwierdzono tylko kilka leków. Mechanizm działania kokcydiostatyków jonoforowych (np. salinomycyny i narazyny) jest związany z zakłóceniem transbłonowego transportu monowalentnych i dwuwalentnych jonów (Na+, K+, Ca2+, Mg2+, Rb+, Cs+), prowadzącym do zmiany gradientu jonowego i wtórnego zaburzenia procesów fizjologicznych u kokcydiów. U brojlerów i indyków leki te podawane są przez prawie cały okres tuczu. Kokcydiostatyki jonoforowe mają wąski margines bezpieczeństwa. Ich toksyczność jest związana z zaburzeniem równowagi jonowej lub uszkodzeniami oksydacyjnymi. Chociaż kokcydiostatyki jonoforowe są uznawane za stosunkowo bezpieczne dla zwierząt docelowych, w literaturze można znaleźć liczne doniesienia na temat zatruć tymi lekami u ptaków. W artykule przedstawiano bieżący stan wiedzy na temat toksyczności salinomycyny i narazyny u indyków, a także dane dotyczące objawów, upadków i możliwych przyczyn zatruć wywołanych tymi lekami. Omawiano również regulacje prawne w zakresie ich stosowania.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
19
Numer
3
Opis fizyczny
p.903-914,ref.
Twórcy
  • Chair of Pharmacology and Toxicology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13 Street, 10-718 Olsztyn, Poland
autor
  • Chair of Pharmacology and Toxicology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13 Street, 10-718 Olsztyn, Poland
  • Sub-Department of Pharmacology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
  • Department of Animal Physiology, University of Life Sciences in Lublin, Lublin, Poland
Bibliografia
  • Andreasen J.R., Schleifer J.H. 1995. Salinomycin toxicosis in male breeder turkeys. Avian Dis., 39(3): 638-642.
  • Braunius W.W. 1985. Ionophorous anticoccidial drugs in coccidiosis control. World`s Poult. Sci. J., 41(3): 198-209.
  • Commission Regulation (EU) No 574/2011 of 16 June 2011 amending Annex I to Directive 2002/32/EC of the European Parliament and of the Council as regards maximum levels for nitrite, melamine, Ambrosia spp. and carry-over of certain coccidiostats and histomonostats and consolidating Annexes I and II thereto. O. J. EC Nr L 159, 7-24.
  • Community Register of Feed Additives: Animal Nutrition - Feed Additives Revision 134 released 8 February 2012.
  • Council Regulation (EEC) No 2377/90 of 26 June 1990 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. O. J. EC Nr L 224, 1-8, with subsequent amendments. Davis C. 1983. Narasin toxicity in turkeys. Vet. Rec., 113, 627.
  • EFSA (European Food Safety Authority) 2004a. Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the re-evaluation of coccidiostat Sacox 120 microGranulate as feed additive in accordance with article 9G of Council Directive 70/524/EEC. EFSA J., 76: 1-49.
  • EFSA (European Food Safety Authority) 2004b. Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a request from the Commission on the evaluation of coccidiostat Kokcisan 120G. EFSA J., 63: 1-41.
  • EFSA (European Food Safety Authority) 2008. Opinion of European Commission on Cross-contamination of non-target feedingstuffs by salinomycin authorised for use as a feed additive. EFSA J., 591: 1-38.
  • Fowler N. G. 1995. Anticoccidial compendium. Beerse, Belgium, Janssen Animal Health., 57: 72-73.
  • Griffiths G.L., Hillier P., Sutherland R. J. 1989. Salinomycin poisoning in point-of-lay turkeys. Aust. Vet. J., 66(10): 326-329.
  • Harries N. 1991. Alberta. Salinomycin toxicity in turkeys. Can. Vet. J., 32(2): 117.
  • Johansen C.H., Bjerrum L., Pedersen K. 2007. Impact of salinomycin on the intestinal microflora of broiler chickens. Acta Vet. Scand., 49:30. DOI:10.1186/1751-0147-49-30
  • Kan C.A., Petz M. 2000. Residues of veterinary drugs in eggs and their distribution between yolk and white. J Agric Food Chem., 48(12): 6397-6403.
  • Kennedy D.G., Hughes P.J., Blanchflower W.J. 1998. Ionophore residues in eggs in Northen Ireland: incidence and cause. Food Addit Contam, 15(5): 535-541.
  • Koutoulis K.C., Kefalas G., Minos E. 2013. Salinomycin toxicosis in broiler breeders and turkeys: report of the first case. Am. J. Anim. Vet. Sci., 8(4): 190-196.
  • Lin J.A. 1995. Mass salinomycin toxicity death to concomitant use of tiamulin in a breeder flock. Taiwan. J. Vet. Med. Anim. Husb., 65: 339-346.
  • Mehlorn H. 2008. Encyclopedia of parasitology. Springer-Verlag Berlin Heilderberg, 3rd edition, 274-276.
  • Mézes M., Sály i G., Bánhidi G., Szeberényi S. 1992. Effect of acute salinomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiler chicken. Acta Vet. Hung., 40(4): 251-257.
  • Moore C., Pressman B.C. 1964. Mechanism of action of valinomycin on mitochondria. Biochem. Biophys. Res. Commun., 15: 562-567.
  • Novilla M. N. 1992. The veterinary importance of the toxic syndrome induced by ionophores. Vet. Hum. Toxicol., 34(1): 66-70.
  • Oehme F.W., Pickrell J.A. 1999. An analysis of the chronic oral toxicity of polyether ionophore antibiotics in animals. Vet. Hum. Toxicol., 41(4): 251-257.
  • Olejnik M., Szprenger-Juszkiewicz T. 2007. Residues of coccidiostats in poultry tissues and eggs. Med. Wet., 63(12): 1539-1545. (in Polish)
  • Olejnik M., Szprenger-Juszkiewicz T., Żmudzki J. 2009. Coccidiostats in animal food and fodder. Med. Wet., 65(12): 807-811. (in Polish)
  • Potter L.M., Blake J.P., Blair M.E., Bliss B.A., Denbov D.M. 1986. Salinomycin toxicity in turkeys. Poult. Sci., 65(10): 1955-1959.
  • Reece R.L. 1988. Review of adverse effects of chemotherapeutic agents in poultry. World`s Poultry Sci. J., 44(3): 193-216.
  • Rizvi F., Anjum A.D., Khan A., Mohsan M., Shazad M. 2008. Pathological and serum biochemical effects of salinomycin on layer chicks. Pakistan Vet. J., 28(2): 71-75.
  • Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition. O. J. EC Nr L 268, 29-43.
  • Regulation (EC) No 545/2006 of 31 March 2006 amending Regulation (EC) No 1464/2004 as regards the conditions of authorisation of the feed additive Monteban belonging to the group of coccidiostats and other medicinal substances. O.J.E.C., No 94, 26-27.
  • Regulation (EC) No 500/2007 of 7 May 2007, amending Regulation (EC) No 1463/2004 as regards the introduction of a maximum residue limit for the feed additive Sacox 120 micro-Granulate, belonging to the group of coccidiostats and other medicinal substances. O.J.E.U. No L 118, 3-4.
  • Regulation of the European Parliament and the Council (EC) No 470/2009 of 6 May 2009, laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin, repealing Council Regulation (EEC) No. 2377/90 and amending Directive 2001/82/EC of the European Parliament and of the Council and Regulation (EC) No. 726/2004 of the European Parliament and of the Council.
  • Salyi G., Szabo E., Bago G., Banhidi G., Szilagy i M. 1988. Narasin poisoning in turkeys. Acta Vet. Hung., 36(1-2): 107-114.
  • Szucs G., Tamasi V., Laczay P., Monostory K. 2004. Biochemical background of toxic interaction between tiamulin and monensin. Chem. Biol. Interact., 147(2): 151-161.
  • Report from the Commission to the Council and European Parliament on the use of coccidiostats and histomonostats as feed additives, of 5 May 2008 pursuant to Art. 11 of Regulation (EC) No 1831/2003 of the European Parliament and Council of 22 September 2003 on the use of feed additives in animal nutrition. Act on Animal Feeds of 22 July 2006. Journal of Law No 144 item 1045, 7499-7520.
  • Witkamp R.F., Nijmeijer, S.M., Monshouwer, M., Van Miert, A.S. 1995. The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig. Drug Metab. Dispos., 23(5): 542-547.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-d019fd54-2bb4-4e4c-be80-97aba61e9c3c
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.