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2016 | 65 | 4 |
Tytuł artykułu

Genotyping and clinicoepidemiological characterization of rotavirus acute gastroenteritis in Egyptian children

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Group A rotavirus (RVA) acute gastroenteritis (AGE) is a common cause of severe childhood diarrhea. The dominant circulating RVA genotypes in a given region may vary between and within the geographic regions and from year to year. Our cross-sectional study was designed to determine the burden of RVA genotypes among children with AGE admitted to referral Children Hospital at Egypt prior to implementation of the vaccine. Stool samples with clinico-epidemiological data were collected from 92 children ≤ 3 years-old with AGE. RVA G and P typing were performed with type-specific primers. RVA was detected in 48.9% of patients. Higher rates of RVA infections, 73.3% were detected in infants < 1 year-old. Breast-fed infants were significantly fewer in RVA positive group (P = 0.0006). Non-breastfeeding was a major risk factor for RVA AGE (OR 0.3, P = 0.02). RVA diarrhea occurred mostly in autumn and winter months (55.4% and 26.6%) with a significant difference in autumn (P = 0.0005) and was associated with vomiting and dehydration (OR; 1.66, P = 0.021 & 1.4, P = 0.03). RVA genotypes G1P[8] (26.7%), G9P[8] (20%) and G3P[8] (15.6%) were accounting for 62.3% of RVA AGE. G9 was significantly associated with mucus diarrhea, than G1 or G3 which were associated with watery diarrhea (P = 0.025). Also, G9 was significantly associated with loose stool for > 5 days (P = 0.006) and 54.4% of G9 patients had severe dehydration. The diversity of RVA strains detected in Nile Delta Egypt and emergence of G9 RVA highlight the need to apply vaccines against this genotype in Egypt.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
65
Numer
4
Opis fizyczny
p.433-442,ref.
Twórcy
autor
  • Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
autor
  • Pediatrics Departments, Faculty of Medicine, Mansoura University, Mansoura, Egypt
autor
  • Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
autor
  • VACSERA-Virology Sector, Cairo, Egypt
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-cfb4141b-8083-4389-a684-07fd56111d06
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